Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer

doi:10.3390/cancers15215291

科研成果详情

题名	Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer
作者	Wang, Zhan 1; Sun, Peng2,3; Li, Zhiyong2,3; Xiao, Shaowen 4
发表日期	2023-11-01
发表期刊	Cancers; 影响因子和分区
语种	英语
原始文献类型	Review
关键词	clinical trials head and neck cancer immunotherapy oncolytic viruses
其他关键词	I DOSE-ESCALATION ; NEURAL STEM-CELLS ; PHASE-I ; ANTIVIRAL IMMUNITY ; RECURRENT HEAD ; GENE-THERAPY ; ADENOVIRUS ; VIRUS ; COMBINATION ; EFFICACY
摘要	Oncolytic viruses (OVs), without harming normal tissues, selectively infect and replicate within tumor cells, to release immune molecules and tumor antigens, achieving immune-mediated destruction of tumors and making them one of the most promising immunotherapies for cancer. Many clinical studies have demonstrated that OVs can provide clinical benefits for patients with different types of tumors, at various stages, including metastatic and previously untreatable cases. When OVs are used in combination with chemotherapy, radiotherapy, immunotherapy, and other treatments, they can synergistically enhance the therapeutic effects. The concept of oncolytic virotherapy (OVT) was proposed in the early 20th century. With advancements in genetic engineering, genetically modified viruses can further enhance the efficacy of cancer immunotherapy. In recent years, global research on OV treatment of malignant tumors has increased dramatically. This article comprehensively reviews the findings from relevant research and clinical trials, providing an overview of the development of OVT and its application in the clinical treatment of head and neck cancer. The aim is to offer insights for future clinical and fundamental research on OVT.
资助项目	Zhejiang College Students’ Innovation and Entrepreneurship Training Program[2022R413A047,2023R413038];National Natural Science Foundations of China[31972680,82102375];National College Students’ Innovation and Entrepreneurship Training Program of China[202310343044];
出版者	MDPI
ISSN	2072-6694
EISSN	2072-6694
卷号	15 期号:21
DOI	10.3390/cancers15215291
页数	14
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001100225800001
收录类别	SCOPUS ; SCIE ; PUBMED
URL	查看原文
PubMed ID	37958464
SCOPUSEID	2-s2.0-85176503820
通讯作者地址	[Wang, Zhan]Department of Stomatology,Wenzhou Medical University Renji College,Wenzhou,325000,China ; [Xiao, Shaowen]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),Department of Radiation Oncology,Peking University Cancer Hospital & Institute,Beijing,100142,China
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184669
专题	仁济学院温州医科大学基础医学院（机能实验教学中心）
通讯作者	Wang, Zhan; Xiao, Shaowen
作者单位	1.Department of Stomatology,Wenzhou Medical University Renji College,Wenzhou,325000,China; 2.School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,325000,China; 3.Cixi Biomedical Research Institute,Wenzhou Medical University,Ningbo,315000,China; 4.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),Department of Radiation Oncology,Peking University Cancer Hospital & Institute,Beijing,100142,China
第一作者单位	仁济学院
通讯作者单位	仁济学院
第一作者的第一单位	仁济学院
推荐引用方式 GB/T 7714	Wang, Zhan,Sun, Peng,Li, Zhiyong,et al. Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer[J]. Cancers;,2023,15(21).
APA	Wang, Zhan, Sun, Peng, Li, Zhiyong, & Xiao, Shaowen. (2023). Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer. Cancers;, 15(21).
MLA	Wang, Zhan,et al."Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer".Cancers; 15.21(2023).