YM155 enhances docetaxel efficacy in ovarian cancer

科研成果详情

题名	YM155 enhances docetaxel efficacy in ovarian cancer
作者	Hou, Li-Jiao1; Huang, Xiao-Xiu 1; Xu, Li-Na1; Zhang, Yan-Yan 1; Zhao, Na 1; Ou, Rong-Ying1; Li, Wen-Feng3; Zhang, Wen-Ji 2; Jiang, Qi-Wei 2; Yang, Yang 2; Wei, Meng-Ning 2; Huang, Jia-Rong 2; Wang, Kun 2; Yuan, Meng-Ling 2; Xing, Zi-Hao 2; Shi, Zhi 2; Yan, Xiao-Jian1
发表日期	2018-12-31
发表期刊	AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ovarian cancer YM155 docetaxel
其他关键词	SEPANTRONIUM BROMIDE YM155 ; MOLECULE SURVIVIN SUPPRESSANT ; NEGATIVE BREAST-CANCER ; MULTIDRUG-RESISTANCE ; VOLASERTIB SUPPRESSES ; DRUG-RESISTANCE ; PLUS DOCETAXEL ; GASTRIC-CANCER ; OPEN-LABEL ; IN-VITRO
摘要	YM155 (Sepantronium bromide) is a potent small molecule inhibitor of survivin by suppression of survivin expression and shows the promising anticancer activity in many types of cancers. Docetaxel (Taxotere (R)) is a member of the taxane drugs used in the treatment of a number of cancers in clinic. Despite the therapeutic efficacy of docetaxel is encouraging, the emergent resistance is an urgent issue. In this study, we investigate the effect of YM155 on docetaxel efficacy in ovarian cancer cells. Our data showed that YM155 actively induced cell growth inhibition, cell cycle arrest and apoptosis with downregualtion of survivin in ovarian cancer cells. Moreover, YM155 increased the intracellular ROS levels, and pretreatment with either NAC or GSH partially reversed the YM155-induced ROS accumulation and apoptosis only in the parental A2780 cells, but not in the resistant A2780/Taxol cells. Furthermore, YM155 enhanced docetaxel efficacy to inhibit the growth and induce apoptosis in ovarian cancer cells. Take together, our results suggested that combination of YM155 and docetaxel may be a feasible strategy for the treatment of ovarian cancer.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81661148049, 81772540, 81503293, 81373075]; Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306001]; Guangdong Special Support Program for Young Talent [2015TQ01R350]; Science and Technology Program of Guangdong [2016A050502027]; Science and Technology Program of Guangzhou [201704030058]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1943-8141
卷号	10 期号:3 页码:696-708
页数	13
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000429097900005
收录类别	SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	2963686
Scopus记录号	2-s2.0-85044737915
通讯作者地址	[Shi, Zhi]Department of Cell Biology & Institute of Biomedicine,National Engineering Research Center of Genetic Medicine,Guangdong Provincial Key Laboratory of Bioengineering Medicine,College of Life Science and Technology,Jinan University,Room 708, The 2nd Engineer and Scientific Building, 601 Huangpu Road West,Guangzhou,510632,China
scopus学科分类	Molecular Medicine;Clinical Biochemistry;Cancer Research
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18459
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第一医院
通讯作者	Shi, Zhi
作者单位	1.Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Cell Biology & Institute of Biomedicine,National Engineering Research Center of Genetic Medicine,Guangdong Provincial Key Laboratory of Bioengineering Medicine,College of Life Science and Technology,Jinan University,Guangzhou,510632,China; 3.Department of Chemoradiotherapy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hou, Li-Jiao,Huang, Xiao-Xiu,Xu, Li-Na,et al. YM155 enhances docetaxel efficacy in ovarian cancer[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2018,10(3):696-708.
APA	Hou, Li-Jiao., Huang, Xiao-Xiu., Xu, Li-Na., Zhang, Yan-Yan., Zhao, Na., ... & Yan, Xiao-Jian. (2018). YM155 enhances docetaxel efficacy in ovarian cancer. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 10(3), 696-708.
MLA	Hou, Li-Jiao,et al."YM155 enhances docetaxel efficacy in ovarian cancer".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 10.3(2018):696-708.