Influence of the FLAG chemotherapy regimen combined with psychologically specific treatment on the effectiveness, anxiety, and weariness of leukaemia patients

doi:10.15761/0101-60830000000635

科研成果详情

题名	Influence of the FLAG chemotherapy regimen combined with psychologically specific treatment on the effectiveness, anxiety, and weariness of leukaemia patients
作者	Chen, Jiao; Wu, Fengyun; Cai, Yongyong
发表日期	2023
发表期刊	Revista de Psiquiatria Clinica; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Anxiety Degree of fatigue FLAG chemotherapy regimen Leukemia Psychological targeted intervention
摘要	Objective: To investigate how the FLAG chemotherapy regimen and psychologically focused intervention affect the effectiveness of leukemia patients and their weariness and anxiety. Methods: The 100 patients diagnosed with leukemia between July 2020 and July 2022 and treated at our hospital were randomly assigned to either a control group (50 cases) or an observation group (50 cases) us ing a random number table. Chemotherapy with fludarabine, cytarabine, and recombinant human granulocyte colony-stimulating factor (FLAG) with standard care was administered to the control group; the observation group received FLAG plus psychologically focused care. Both groups received uninterrupted treatment for a full four weeks. Score on the Self-Rating Anxiety Scale (SAS), Score on the Revised Piper Fatigue SelfRating Scale, Score on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQC30), and Overall Remission Rate (ORR); The frequency of side effects was compared between the two groups. Results: ORR in the observation group was 58.00%, which is considerably higher than in the control group (42.00%; P<0.05). SAS and PFS-R scores were considerably lower in the observation group than in the control group after therapy (P<0.05), and both were significantly lower after treatment in both groups overall. The EORTC QLQ-C30 score for both groups was considerably higher after treatment compared to pretreatment levels, however the score for the observation group was significantly higher than that of the control group (P<0.05); The observation group exhibited significantly higher rates of alanine aminotransferase (16.0%), stomatitis (20.00%), and fever (32.00%) compared to the control group (42.00%, 68.00%, 68.00%) (P<0.05). Conclusion: A high clinical reference value FLAG chemotherapy regimen can increase the efficacy of leukemia patients, reduce anxiety and fatigue, improve patients' quality of life, lower the risk of adverse reactions, and improve efficacy when combined with psychological targeted intervention.
ISSN	0101-6083
EISSN	1806-938X
卷号	50 期号:4 页码:88-93
DOI	10.15761/0101-60830000000635
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85172376015
通讯作者地址	[Chen, Jiao]Department of hematopathology,Pingyang Hospital affiliated to Wenzhou Medical University,Pingyang County, Zhejiang Province,Wenzhou City,325400,China
Scopus学科分类	Psychiatry and Mental Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184596
专题	其他_附属平阳医院（平阳县人民医院）
通讯作者	Chen, Jiao
作者单位	Department of hematopathology,Pingyang Hospital affiliated to Wenzhou Medical University,Wenzhou City,325400,China
第一作者单位	其他_附属平阳医院（平阳县人民医院）
通讯作者单位	其他_附属平阳医院（平阳县人民医院）
第一作者的第一单位	其他_附属平阳医院（平阳县人民医院）
推荐引用方式 GB/T 7714	Chen, Jiao,Wu, Fengyun,Cai, Yongyong. Influence of the FLAG chemotherapy regimen combined with psychologically specific treatment on the effectiveness, anxiety, and weariness of leukaemia patients[J]. Revista de Psiquiatria Clinica;,2023,50(4):88-93.
APA	Chen, Jiao, Wu, Fengyun, & Cai, Yongyong. (2023). Influence of the FLAG chemotherapy regimen combined with psychologically specific treatment on the effectiveness, anxiety, and weariness of leukaemia patients. Revista de Psiquiatria Clinica;, 50(4), 88-93.
MLA	Chen, Jiao,et al."Influence of the FLAG chemotherapy regimen combined with psychologically specific treatment on the effectiveness, anxiety, and weariness of leukaemia patients".Revista de Psiquiatria Clinica; 50.4(2023):88-93.