The role of anesthesia in peri‑operative neurocognitive disorders: Molecular mechanisms and preventive strategies

doi:10.1016/j.fmre.2023.02.007

科研成果详情

题名	The role of anesthesia in peri‑operative neurocognitive disorders: Molecular mechanisms and preventive strategies
作者	Li, Ran 1; Zhang, Yun 2; Zhu, Qinxin1; Wu, Yili1,3; Song, Weihong1,2,3
发表日期	2023
发表期刊	Fundamental Research 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Alzheimer's disease Dexmedetomidine General anesthesia Peri-operative neurocognitive disorders Postoperative cognitive dysfunction Postoperative delirium
其他关键词	POSTOPERATIVE COGNITIVE DYSFUNCTION ; P75 NEUROTROPHIN RECEPTOR ; ISCHEMIA-REPERFUSION INJURY ; AWAKE-REGIONAL ANESTHESIA ; CEREBRAL-BLOOD-FLOW ; GENERAL-ANESTHESIA ; SEVOFLURANE ANESTHESIA ; TAU PHOSPHORYLATION ; INDUCED APOPTOSIS ; OXIDE ANESTHESIA
摘要	Peri-operative neurocognitive disorders (PNDs) include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). Children and the elderly are the two populations most vulnerable to the development of POD and POCD, which results in both high morbidity and mortality. There are many factors, including neuroinflammation and oxidative stress, that are associated with POD and POCD. General anesthesia (GA) is a major risk factor of PNDs. However, the molecular mechanisms of PNDs are poorly understood. Dexmedetomidine (DEX) is a useful sedative agent with analgesic properties, which significantly improves POCD in elderly patients. In this review, the current understanding of anesthesia in PNDs and the protective effects of DEX are summarized, and the underlying mechanisms are further discussed.
资助项目	National Natural Science Foundation of China[82150710557,82293642];
出版者	KEAI PUBLISHING LTD
ISSN	2096-9457
EISSN	2667-3258
卷号	4 期号:4 页码:797-805
DOI	10.1016/j.fmre.2023.02.007
页数	9
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001294752900001
收录类别	SCOPUS ; ESCI
URL	查看原文
PubMed ID	39161414
SCOPUSEID	2-s2.0-85150242413
通讯作者地址	[Wu, Yili]The Second Affiliated Hospital and Yuying Children's Hospital,Institute of Aging,Key Laboratory of Alzheimer's Disease of Zhejiang Province,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184400
专题	卓越中心_老年研究院
通讯作者	Wu, Yili; Song, Weihong
作者单位	1.The Second Affiliated Hospital and Yuying Children's Hospital,Institute of Aging,Key Laboratory of Alzheimer's Disease of Zhejiang Province,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing,100053,China; 3.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Zhejiang,Wenzhou,325000,China
第一作者单位	卓越中心_老年研究院
通讯作者单位	卓越中心_老年研究院
第一作者的第一单位	卓越中心_老年研究院
推荐引用方式 GB/T 7714	Li, Ran,Zhang, Yun,Zhu, Qinxin,et al. The role of anesthesia in peri‑operative neurocognitive disorders: Molecular mechanisms and preventive strategies[J]. Fundamental Research,2023,4(4):797-805.
APA	Li, Ran, Zhang, Yun, Zhu, Qinxin, Wu, Yili, & Song, Weihong. (2023). The role of anesthesia in peri‑operative neurocognitive disorders: Molecular mechanisms and preventive strategies. Fundamental Research, 4(4), 797-805.
MLA	Li, Ran,et al."The role of anesthesia in peri‑operative neurocognitive disorders: Molecular mechanisms and preventive strategies".Fundamental Research 4.4(2023):797-805.