Analysis of the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 for intrahepatic parenchymal substantial lesions ≤3.0 cm

doi:10.3760/cma.j.cn501113-20210219-00086

科研成果详情

题名	Analysis of the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 for intrahepatic parenchymal substantial lesions ≤3.0 cm
其他题名	Analysis of the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 for intrahepatic parenchymal substantial lesions ≤3.0 cm
作者	Li B.R.1; Zhao X.M.2; Zou J.X.3; Su Z.L.4; Deng C.D.5; Yan X.B.6; Xiao Y.R.1; Wang Z.F.1; Yang Y.J.2; Long L.L.5; Chen M.7; Peng S.5; Ji J.S.1
发表日期	2022-11-20
发表期刊	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	肝肿瘤磁共振成像肝脏影像报告和数据系统
其他关键词	Liver neoplasms ; Magnetic resonance imaging ; Liver imaging reporting and data system
摘要	目的：探讨2018版MRI肝脏影像报告和数据系统（LI-RADS v2018）对肝细胞癌（HCC）高危风险患者肝内≤3.0 cm实质性病变的诊断效能。方法：回顾性分析2014年9月至2020年4月间经病理证实且病灶长径≤3.0 cm的131例非HCC病例资料，并按1∶1比例随机匹配131例病灶长径≤3.0 cm的HCC病例，分为良性组（56例）、肝脏其他恶性肿瘤（OM）组（75例）、HCC组（131例）。分析病灶的MRI征象并依据LI-RADS v2018标准对病灶进行分类（对兼有HCC征象和LR-M征象的病灶运用平局决胜规则）。以病理结果为金标准，计算LI-RADS v2018分类标准和更严格的LR-5标准（同时具备3个HCC主要征象）对诊断HCC、OM或良性病变的灵敏度、特异度。分类结果的比较采用Mann-Whitney U检验。结果：应用平局决胜规则后HCC组归类为LR-M、LR-1、LR-2、LR-3、LR-4、LR-5的例数分别为14、0、0、12、28、77例，OM组分别为40、0、0、4、17、14例，良性组分别为8、5、1、26、13、3例；HCC组、OM组、良性组归为LR-5的病灶中符合更严格LR-5标准的例数分别为41例（41/77）、4例（4/14）、1例（1/3）；以LR-4联合LR-5（LR-4/5）标准、LR-5标准、“更严格的LR-5标准”诊断HCC的灵敏度分别为80.2%（105/131）、58.8%（77/131）、31.3%（41/131），特异度分别为64.1%（84/131）、87.0%（114/131）、96.2%（126/131）；以LR-M标准诊断OM的灵敏度为53.3%（40/75）、特异度为88.2%（165/187）；以LR-1联合LR-2（LR-1/2）标准诊断肝良性病变的灵敏度为10.7%（6/56）、特异度为100%（206/206）。结论：对肝内长径≤3.0 cm的病灶，LR-1/2、LR-5、LR-M标准相应的诊断特异度均较高；归类为LR-3的病灶更可能是良性病变；以LR-4/5标准诊断HCC的特异度低；更严格的LR-5标准对诊断HCC具有更高的特异度。. Objective: To investigate the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 in high-risk hepatocellular carcinoma (HCC) patients with intrahepatic parenchymal substantial lesions ≤3.0 cm. Methods: A retrospective analysis was conducted in hospitals between September 2014 to April 2020. 131 pathologically confirmed non-HCC cases with lesions ≤3.0 cm in diameter were randomly matched with 131 cases with lesions ≤3.0 cm in diameter and divided into benign (56 cases), other hepatic malignant tumor (OM, 75 cases), and HCC group (131 cases) in a 1:1 ratio. MRI features of the lesions were analyzed and classified according to LI-RADS v2018 criteria (tie-break rule was applied to lesions with both HCC and LR-M features). Taking the pathological results as the gold standard, the sensitivity and specificity of the LI-RADS v2018 classification criteria and the more stringent LR-5 criteria (with three main signs of HCC at the same time) were calculated for HCC, OM or benign lesions diagnosis. Mann -Whitney U test was used to compare the classification results. Results: The number of cases classified as LR-M, LR-1, LR-2, LR-3, LR-4, and LR-5 in HCC group after applying the tie-break rule were 14, 0, 0, 12, 28, and 77, respectively. There were 40, 0, 0, 4, 17, 14 and 8, 5, 1, 26, 13, 3 cases in benign and OM group, respectively. There were 41 (41/77), 4 (4/14) and 1 (1/3) lesion case in the HCC, OM and benign group, respectively, that met the more stringent LR-5 criteria. The sensitivity of LR-4 combined with LR-5 (LR-4/5) criteria, LR-5 criteria and more stringent LR-5 criteria for HCC diagnosis were 80.2% (105/131), 58.8% (77/131) and 31.3% (41/131), respectively, and the specificity were 64.1% (84/131), 87.0% (114/131) and 96.2% (126/131), respectively. The sensitivity and specificity of LR-M were 53.3% (40/75) and 88.2% (165/187), respectively. The sensitivity and specificity using LR-1 combined with LR-2 (LR-1/2) criteria for the diagnosis of benign liver lesions were 10.7% (6/56) and 100% (206/206), respectively. Conclusions: LR-1/2, LR-5, and LR-M criteria have high diagnostic specificity for intrahepatic lesions with a diameter of ≤3.0 cm. Lesions classified as LR-3 are more likely to be benign. The specificity of LR-4/5 criteria is low, while the more stringent LR-5 criteria has a high specificity for HCC diagnosis.
其他摘要	Objective:To investigate the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 in high-risk hepatocellular carcinoma (HCC) patients with intrahepatic parenchymal substantial lesions ≤3.0 cm.Methods:A retrospective analysis was conducted in hospitals between September 2014 to April 2020. 131 pathologically confirmed non-HCC cases with lesions ≤3.0 cm in diameter were randomly matched with 131 cases with lesions ≤3.0 cm in diameter and divided into benign (56 cases), other hepatic malignant tumor (OM, 75 cases), and HCC group (131 cases) in a 1:1 ratio. MRI features of the lesions were analyzed and classified according to LI-RADS v2018 criteria (tie-break rule was applied to lesions with both HCC and LR-M features). Taking the pathological results as the gold standard, the sensitivity and specificity of the LI-RADS v2018 classification criteria and the more stringent LR-5 criteria (with three main signs of HCC at the same time) were calculated for HCC, OM or benign lesions diagnosis. Mann -Whitney U test was used to compare the classification results. Results:The number of cases classified as LR-M, LR-1, LR-2, LR-3, LR-4, and LR-5 in HCC group after applying the tie-break rule were 14, 0, 0, 12, 28, and 77, respectively. There were 40, 0, 0, 4, 17, 14 and 8, 5, 1, 26, 13, 3 cases in benign and OM group, respectively. There were 41 (41/77), 4 (4/14) and 1 (1/3) lesion case in the HCC, OM and benign group, respectively, that met the more stringent LR-5 criteria. The sensitivity of LR-4 combined with LR-5 (LR-4/5) criteria, LR-5 criteria and more stringent LR-5 criteria for HCC diagnosis were 80.2% (105/131), 58.8% (77/131) and 31.3% (41/131), respectively, and the specificity were 64.1% (84/131), 87.0% (114/131) and 96.2% (126/131), respectively. The sensitivity and specificity of LR-M were 53.3% (40/75) and 88.2% (165/187), respectively. The sensitivity and specificity using LR-1 combined with LR-2 (LR-1/2) criteria for the diagnosis of benign liver lesions were 10.7% (6/56) and 100% (206/206), respectively.Conclusions:LR-1/2, LR-5, and LR-M criteria have high diagnostic specificity for intrahepatic lesions with a diameter of ≤3.0 cm. Lesions classified as LR-3 are more likely to be benign. The specificity of LR-4/5 criteria is low, while the more stringent LR-5 criteria has a high specificity for HCC diagnosis.
ISSN	1007-3418
卷号	30 期号:11 页码:1211-1217
DOI	10.3760/cma.j.cn501113-20210219-00086
页数	7
收录类别	SCOPUS ; PUBMED ; 万方 ; ISTIC ; CSCD ; 北大核心
URL	查看原文
PubMed ID	36891700
SCOPUSEID	2-s2.0-85149692370
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184385
专题	附属第一医院其他_附属平阳医院（平阳县人民医院）
作者单位	1.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research of Zhejiang Province,Department of Radiology,Central Hospital of Lishui City,Lishui,323000,China; 2.Department of Radiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Radiology,People's Hospital of Lishui City,Lishui,323000,China; 4.Department of Radiology,Pingyang Affiliated Hospital of Wenzhou Medical University,Wenzhou,325400,China; 5.Department of Radiology,First Affiliated Hospital of Guangxi Medical University,Nanning,530021,China; 6.Department of Radiology,Suichang People's Hospital of Lishui City,Lishui,323300,China; 7.Department of Radiology,Beijing Hospital,Beijing,100730,China
推荐引用方式 GB/T 7714	Li B.R.,Zhao X.M.,Zou J.X.,et al. Analysis of the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 for intrahepatic parenchymal substantial lesions ≤3.0 cm[J]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,2022,30(11):1211-1217.
APA	Li B.R.., Zhao X.M.., Zou J.X.., Su Z.L.., Deng C.D.., ... & Ji J.S.. (2022). Analysis of the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 for intrahepatic parenchymal substantial lesions ≤3.0 cm. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 30(11), 1211-1217.
MLA	Li B.R.,et al."Analysis of the diagnostic performance of MRI Liver Imaging Reporting and Data System version 2018 for intrahepatic parenchymal substantial lesions ≤3.0 cm".Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 30.11(2022):1211-1217.