Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

doi:10.3390/ph16010110

科研成果详情

题名	Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
作者	Rahim, Nur Syafiqah 1,2,3; Wu, Yuan Seng 4,5; Sim, Maw Shin 1; Velaga, Appalaraju 6; Bonam, Srinivasa Reddy 7; Gopinath, Subash C. B.8,9,10; Subramaniyan, Vetriselvan 11; Choy, Ker Woon 12; Teow, Sin-Yeang 13; Fareez, Ismail M.3,14; Samudi, Chandramathi 15; Sekaran, Shamala Devi 16; Sekar, Mahendran 17; Guad, Rhanye Mac 18
发表日期	2023
发表期刊	Pharmaceuticals 影响因子和分区
语种	英语
原始文献类型	Review
关键词	cancer progression chemoresistance targeted cancer therapy TM4SF transmembrane 4 L6 domain family transmembrane 4 superfamily
摘要	There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has demonstrated, among six TM4SF members, the regulatory roles of transmembrane 4 L6 domain family members, particularly TM4SF1, TM4SF4, and TM4SF5, in cancer angiogenesis, progression, and chemoresistance. Hence, targeting derailed TM4SF for cancer therapy has become an emerging research area. As compared to others, this review aimed to present a focused insight and update on the biological roles of TM4SF1, TM4SF4, and TM4SF5 in the progression, metastasis, and chemoresistance of various cancers. Additionally, the mechanistic pathways, diagnostic and prognostic values, and the potential and efficacy of current anti-TM4SF antibody treatment were also deciphered. It also recommended the exploration of other interactive molecules to be implicated in cancer progression and chemoresistance, as well as potential therapeutic agents targeting TM4SF as future perspectives. Generally, these three TM4SF members interact with different integrins and receptors to significantly induce intracellular signaling and regulate the proliferation, migration, and invasion of cancer cells. Intriguingly, gene silencing or anti-TM4SF antibody could reverse their regulatory roles deciphered in different preclinical models. They also have prognostic and diagnostic value as their high expression was detected in clinical tissues and cells of various cancers. Hence, TM4SF1, TM4SF4, and TM4SF5 are promising therapeutic targets for different cancer types preclinically and deserve further investigation.
ISSN	1424-8247
卷号	16 期号:1
DOI	10.3390/ph16010110
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85146744062
通讯作者地址	[Wu, Yuan Seng]Centre for Virus and Vaccine Research,School of Medical and Life Sciences,Sunway University,Petaling Jaya,47500,Malaysia ; [Guad, Rhanye Mac]Department of Biomedical Science and Therapeutics,Faculty of Medicine and Health Science,Universiti Malaysia Sabah,Kota Kinabalu,88400,Malaysia
Scopus学科分类	Molecular Medicine;Pharmaceutical Science;Drug Discovery
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184345
专题	温州医科大学
通讯作者	Wu, Yuan Seng; Guad, Rhanye Mac
作者单位	1.Department of Pharmaceutical Life Sciences,Faculty of Pharmacy,Universiti Malaya,Kuala Lumpur,50603,Malaysia; 2.Department of Biology,Faculty of Applied Sciences,Universiti Teknologi MARA,Perlis Branch,Arau Campus,Arau,02600,Malaysia; 3.Collaborative Drug Discovery Research (CDDR) Group,Faculty of Pharmacy,Universiti Teknologi MARA (UiTM),Selangor Branch,Puncak Alam Campus,Bandar Puncak Alam,42300,Malaysia; 4.Centre for Virus and Vaccine Research,School of Medical and Life Sciences,Sunway University,Petaling Jaya,47500,Malaysia; 5.Department of Biological Sciences,School of Medical and Life Sciences,Sunway University,Petaling Jaya,47500,Malaysia; 6.Department of Medicinal Chemistry,Faculty of Pharmacy,MAHSA University,Jenjarom,42610,Malaysia; 7.Department of Microbiology and Immunology,University of Texas Medical Branch,301 University Blvd,Galveston,77555,United States; 8.Faculty of Chemical Engineering & Technology,Universiti Malaysia Perlis (UniMAP),Arau,02600,Malaysia; 9.Institute of Nano Electronic Engineering,Universiti Malaysia Perlis (UniMAP),Kangar,01000,Malaysia; 10.Micro System Technology,Centre of Excellence (CoE),Universiti Malaysia Perlis (UniMAP),Pauh Campus,Arau,02600,Malaysia; 11.Department of Pharmacology,School of Medicine,Faculty of Medicine,Bioscience and Nursing,MAHSA University,Jenjarom,42610,Malaysia; 12.Department of Anatomy,Faculty of Medicine,Universiti Teknologi MARA,Sungai Buloh,47000,Malaysia; 13.Department of Biology,College of Science and Technology,Wenzhou-Kean University,88 Daxue Road, Quhai,Wenzhou,325060,China; 14.School of Biology,Faculty of Applied Sciences,Universiti Teknologi MARA,Selangor Branch, Shah Alam Campus,Shah Alam,40450,Malaysia; 15.Department of Medical Microbiology,Faculty of Medicine,Universiti Malaya,Kuala Lumpur,50603,Malaysia; 16.Faculty of Medical and Health Sciences,UCSI University,Kuala Lumpur,56000,Malaysia; 17.Department of Pharmaceutical Chemistry,Faculty of Pharmacy and Health Sciences,Royal College of Medicine Perak,Universiti Kuala Lumpur,Ipoh,30450,Malaysia; 18.Department of Biomedical Science and Therapeutics,Faculty of Medicine and Health Science,Universiti Malaysia Sabah,Kota Kinabalu,88400,Malaysia
推荐引用方式 GB/T 7714	Rahim, Nur Syafiqah,Wu, Yuan Seng,Sim, Maw Shin,et al. Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance[J]. Pharmaceuticals,2023,16(1).
APA	Rahim, Nur Syafiqah., Wu, Yuan Seng., Sim, Maw Shin., Velaga, Appalaraju., Bonam, Srinivasa Reddy., ... & Guad, Rhanye Mac. (2023). Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance. Pharmaceuticals, 16(1).
MLA	Rahim, Nur Syafiqah,et al."Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance".Pharmaceuticals 16.1(2023).