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题名A case of protein S deficiency complicated with cerebral embolism and peripheral arterial embolism 蛋白 S 缺乏症合并脑梗死及外周动脉阻塞 1 例
其他题名A case of protein S deficiency complicated with cerebral embolism and peripheral arterial embolism
作者
发表日期2022-10-28
发表期刊Journal of Shanghai Jiaotong University (Medical Science)   影响因子和分区
语种中文
原始文献类型Article
关键词artery occlusion cerebral infarction protein S deficiency (PSD) thrombophilia
摘要The patient, a 49-year-old male, was admitted to Zhoushan Hospital Affiliated to Wenzhou Medical University in January 2022. He complained of walking instability without obvious inducement for more than 1 month. He had a history of thrombophlebitis and no family history of arterial or venous thrombosis. He had two episodes of acute cerebral infarction, and the tests for thrombophilia in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine showed that the total amount of protein S was 26.7%, and he had a heterozygous mutation C.1955A>T, p.Asp652Val in the exon 15 of PROS1 gene. Then he was diagnosed as having hereditary protein S deficiency (PSD), and thereafter he was given long-term oral rivaroxaban tablets for anticoagulation. This time the physical examinations showed no abnormalities except slightly unsteady walking. The patient scored 6 points in the Venous Thromboembolism (VTE) Risk Assessment Scale (Padua model) with high risk of VTE. Holter testing showed sinus rhythms with occasional premature atrial beats and premature ventricular beats. B-ultrasound for the vessels in the extremities showed multiple thrombus formation with local stenosis in the bilateral popliteal arteries and the posterior tibial arteries, and occlusion in the right radial artery. Echocardiography and carotid ultrasound showed no obvious abnormalities. Cranial MRI showed an old cerebral infarction lesion in the left basal ganglia region. CT angiography combined with three-dimensional reconstruction showed severe stenosis and possible occlusion in the M1 segment of the left middle cerebral artery, and stenosis and sclerosis of the siphon segment of the bilateral internal carotid arteries. Finally, the patient was diagnosed as having PSD with cerebral infarction and peripheral arterials obstruction. He was treated with rosuvastatin calcium for stabilizing plaques, rivaroxaban for anticoagulation, metoprolol succinate for controlling ventricular rhythms, and folic acid for improving metabolism. After 10 d of treatment, the patient's symptoms were improved.
资助项目JG2021176:温州医科大学校级高等教育教学改革项目
ISSN1674-8115
卷号42期号:10页码:1511-1516
DOI10.3969/j.issn.1674-8115.2022.10.019
页数6
收录类别SCOPUS ; 万方 ; ISTIC ; 北大核心
URL查看原文
SCOPUSEID2-s2.0-85144351123
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/184310
专题其他_附属舟山医院(舟山医院)
通讯作者Lü, Mingshun
作者单位
1.Department of Ultrasound,Zhoushan Hospital Affiliated to Wenzhou Medical University,Zhoushan,316000,China;
2.Department of Ultrasound,Zhoushan Branch,Ruijin Hospital,Shanghai Jiao Tong University,School of Medicine,Zhoushan,316000,China
第一作者单位其他_附属舟山医院(舟山医院)
第一作者的第一单位其他_附属舟山医院(舟山医院)
推荐引用方式
GB/T 7714
Lü, Mingshun,Zhang, Zihong,Wang, Mei. A case of protein S deficiency complicated with cerebral embolism and peripheral arterial embolism 蛋白 S 缺乏症合并脑梗死及外周动脉阻塞 1 例[J]. Journal of Shanghai Jiaotong University (Medical Science),2022,42(10):1511-1516.
APA Lü, Mingshun, Zhang, Zihong, & Wang, Mei. (2022). A case of protein S deficiency complicated with cerebral embolism and peripheral arterial embolism 蛋白 S 缺乏症合并脑梗死及外周动脉阻塞 1 例. Journal of Shanghai Jiaotong University (Medical Science), 42(10), 1511-1516.
MLA Lü, Mingshun,et al."A case of protein S deficiency complicated with cerebral embolism and peripheral arterial embolism 蛋白 S 缺乏症合并脑梗死及外周动脉阻塞 1 例".Journal of Shanghai Jiaotong University (Medical Science) 42.10(2022):1511-1516.

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