Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats

doi:10.3389/fphar.2022.938849

科研成果详情

题名	Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats
作者	Zhu, Yitian 1; Zhang, Luyun 2; Zhang, Xiafeng 2; Wu, Dehong 3; Chen, Leiming 4; Hu, Changfeng 2; Wen, Chengping 2; Zhou, Jia 2
发表日期	2022-08-29
发表期刊	Frontiers in Pharmacology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	collagen-induced arthritis lipid metabolism rheumatoid arthritis shotgun lipidomics Tripterygium wilfordii glycosides
摘要	Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and the dysregulation of lipid metabolism has been found to play an important role in the pathogenesis of RA and is related to the severity and prognosis of patients. Tripterygium wilfordii glycosides (TWG) is extracted from the roots of Tripterygium wilfordii Hook F. with anti-inflammatory and immunosuppressive effects, and numerous clinical trials have supported its efficacy in the treatment of RA. Some evidence suggested that TWG can modulate the formation of lipid mediators in various innate immune cells; however whether it can improve RA-related lipid disorders has not been systematically studied. In the study, type Ⅱ collagen-induced arthritis (CIA) model was used to investigate the efficacy of TWG in the treatment of RA and its effect on lipid metabolism. Paw volume, arthritis score, pathological changes of ankle joint, serum autoantibodies and inflammatory cytokines were detected to assess the therapeutic effect on arthritis in CIA rats. Then, shotgun lipidomics based on multi-dimensional mass spectrometry platform was performed to explore the alterations in serum lipidome caused by TWG. The study showed that TWG could effectively ameliorate arthritis in CIA rats, such as reducing paw volume and arthritis score, alleviating the pathological damages of joint, and preventing the production of anti-CII autoantibodies and IL-1β cytokine. Significant increase in ceramide and decrease in lysophosphatidylcholine were observed in CIA rats, and were highly correlated with arthritis score and IL-1β level. After TWG treatment, these lipid abnormalities can be corrected to a great extent. These data demonstrate that TWG exerts a beneficial therapeutic effect on aberrant lipid metabolism which may provide new insights for further exploring the role and mechanism of TWG in the treatment of RA.
资助项目	National Natural Science Foundation of China[81403269];National Key R&D Program of China[2018YFC1705500];
ISSN	1663-9812
卷号	13
DOI	10.3389/fphar.2022.938849
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85138277027
通讯作者地址	[Wen, Chengping]Institute of Basic Research in Clinical Medicine,College of Basic Medical Science,Zhejiang Chinese Medical University,Hangzhou,China ; [Zhou, Jia]Institute of Basic Research in Clinical Medicine,College of Basic Medical Science,Zhejiang Chinese Medical University,Hangzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184244
专题	温州医科大学
通讯作者	Wen, Chengping; Zhou, Jia
作者单位	1.The Second Clinical Medical College of Zhejiang,Chinese Medical University,Hangzhou,China; 2.Institute of Basic Research in Clinical Medicine,College of Basic Medical Science,Zhejiang Chinese Medical University,Hangzhou,China; 3.The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China; 4.Department of Nephrology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,China
推荐引用方式 GB/T 7714	Zhu, Yitian,Zhang, Luyun,Zhang, Xiafeng,et al. Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats[J]. Frontiers in Pharmacology,2022,13.
APA	Zhu, Yitian., Zhang, Luyun., Zhang, Xiafeng., Wu, Dehong., Chen, Leiming., ... & Zhou, Jia. (2022). Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats. Frontiers in Pharmacology, 13.
MLA	Zhu, Yitian,et al."Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats".Frontiers in Pharmacology 13(2022).