Inhibition of Transverse Aortic Constriction Induced Myocardial Hypertrophy by Knocking out the Target of the Early Growth Response-1 to Inhibit Apoptosis and Autophagy

doi:10.1166/jbn.2023.3674

科研成果详情

题名	Inhibition of Transverse Aortic Constriction Induced Myocardial Hypertrophy by Knocking out the Target of the Early Growth Response-1 to Inhibit Apoptosis and Autophagy
作者	Wu, Huiping3,4; Li, Jie1,2; Xia, Tianhe1,2; He, Yue'e 1,2; Wu, Tingting1,2; Wang, Zhenquan 1,2; Song, Shiyang1,2; Chu, Maoping1,2; Rong, Xing1,2
发表日期	2023-10
发表期刊	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	TOE1 Myocardial Hypertrophy Transverse Aortic Constriction Apoptosis Autophagy
摘要	Myocardial hypertrophy, a significant contributor to the development of heart failure, continues to be prevalent. Early growth response-1 (EGR-1) is closely linked to the development of diverse myocardial conditions. The target of EGR1 (TOE1) is a critical factor in myocardial hypertrophy, but its regulatory function remains unclear. Myocardial cell injury was induced by angiotensin II. TOE1 knockout mice ad cells were generated to investigate its impact on myocardial IP: 203.8.109.20 On: Sun, 29 Oct 2023 05:59:19 hypertrophy. TUNEL staining was employed to assess cell apoptosis. Furthermore, western blotting and qRT-PCR were Copyright: American Scienti ic Publisher performed to measure the expression of target genes. The results revealed that knockout of TOE1 effectively inhibited Delivered by Ingenta myocardial hypertrophy and injury caused by transverse aortic constriction. In vivo experiments demonstrated that TOE1 knockout improved myocardial function and suppressed inflammatory factors, oxidative stress, apoptosis, and autophagy levels. In vitro, TOE1 knockout suppressed cell apoptosis, mitochondrial damage, and the intensity of reactive oxygen species. Additionally, it inhibited the expression of apoptosis-and autophagy-related genes. These findings introduce a promising avenue for preventing and treating myocardial hypertrophy.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LY18H020012]
出版者	AMER SCIENTIFIC PUBLISHERS
ISSN	1550-7033
EISSN	1550-7041
卷号	19 期号:10 页码:1832-1840
DOI	10.1166/jbn.2023.3674
页数	9
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001092334300001
收录类别	SCIE
通讯作者地址	[Chu, Maoping;Rong, Xing]Wenzhou Med Univ, Affiliated Hosp 2, Childrens Heart Ctr, Key Lab Struct Malformat Children Zhejiang Prov, Wenzhou 325000, Zhejiang, Peoples R China.;Rong, Xing]Wenzhou Med Univ, Yuying Childrens Hosp, Key Lab Struct Malformat Children Zhejiang Prov, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184068
专题	附属第二医院_儿童心血管科附属第二医院第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Chu, Maoping; Rong, Xing
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Childrens Heart Ctr, Key Lab Struct Malformat Children Zhejiang Prov, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Key Lab Struct Malformat Children Zhejiang Prov, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat Endocrine Genet & Metab, Wenzhou 325000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	附属第二医院_儿童心血管科
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Wu, Huiping,Li, Jie,Xia, Tianhe,et al. Inhibition of Transverse Aortic Constriction Induced Myocardial Hypertrophy by Knocking out the Target of the Early Growth Response-1 to Inhibit Apoptosis and Autophagy[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2023,19(10):1832-1840.
APA	Wu, Huiping., Li, Jie., Xia, Tianhe., He, Yue'e., Wu, Tingting., ... & Rong, Xing. (2023). Inhibition of Transverse Aortic Constriction Induced Myocardial Hypertrophy by Knocking out the Target of the Early Growth Response-1 to Inhibit Apoptosis and Autophagy. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 19(10), 1832-1840.
MLA	Wu, Huiping,et al."Inhibition of Transverse Aortic Constriction Induced Myocardial Hypertrophy by Knocking out the Target of the Early Growth Response-1 to Inhibit Apoptosis and Autophagy".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 19.10(2023):1832-1840.