Enhanced GSDME-mediated pyroptosis in Alzheimer's disease

doi:10.1016/j.neuroscience.2023.11.004

科研成果详情

题名	Enhanced GSDME-mediated pyroptosis in Alzheimer's disease
作者	Qunxian Wang 1; Shipeng Guo 1; Dongjie Hu 1; Xiangjun Dong 1; Zijun Meng 1; Yanshuang Jiang 1; Zijuan Feng 1; Weihui Zhou 2; Weihong Song3
发表日期	2023-11-07
发表期刊	Neuroscience 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Alzheimer’s disease (AD) Aβ GSDME cognitive impairments pyroptosis
摘要	Amyloid β protein (Aβ) is a critical factor in the pathogenesis of Alzheimer's disease (AD). Aβ induces apoptosis, and gasdermin-E (GSDME) expression can switch apoptosis to pyroptosis. In this study, we demonstrated that GSDME was highly expressed in the hippocampus of APP23/PS45 mouse models compared to that in age-matched wild-type mice. Aβ treatment induced pyroptosis by active caspase-3 /GSDME in SH-SY5Y cells. Furthermore, the knockdown of GSDME improved the cognitive impairments of APP23/PS45 mice by alleviating inflammatory response. Our findings reveal that GSDME, as a modulator of Aβ and pyroptosis, plays a potential role in Alzheimer's disease pathogenesis and shows that GSDME is a therapeutic target for AD.
ISSN	0306-4522
EISSN	1873-7544
卷号	536
DOI	10.1016/j.neuroscience.2023.11.004
收录类别	PUBMED
URL	查看原文
PubMed ID	37944579
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183812
专题	卓越中心_老年研究院
作者单位	1.Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; 2.Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: zwh@hospital.cqmu.edu.cn.; 3.Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325001, China. Electronic address: weihong@wmu.edu.cn.
推荐引用方式 GB/T 7714	Qunxian Wang,Shipeng Guo,Dongjie Hu,et al. Enhanced GSDME-mediated pyroptosis in Alzheimer's disease[J]. Neuroscience,2023,536.
APA	Qunxian Wang., Shipeng Guo., Dongjie Hu., Xiangjun Dong., Zijun Meng., ... & Weihong Song. (2023). Enhanced GSDME-mediated pyroptosis in Alzheimer's disease. Neuroscience, 536.
MLA	Qunxian Wang,et al."Enhanced GSDME-mediated pyroptosis in Alzheimer's disease".Neuroscience 536(2023).