Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence

doi:10.1002/ddr.22131

科研成果详情

题名	Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence
作者	Zhu, Xiao-Bin 1; Xu, Yao-Yao2; Li, Liu-Cheng 1; Sun, Jia-Bin 3; Wang, Yu-Zhen 1; Chen, Jie 1; Wang, Chen 1; Zhang, Su 4; Jin, Liang-Yan 5
发表日期	2023-11-09
发表期刊	Drug development research 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Alzheimer's disease depression neurocognition proprotein convertase subtilisin/kexin type 9 stroke
其他关键词	PCSK9 VARIANTS ; CHOLESTEROL ; STROKE ; RISK ; INHIBITION ; EVOLOCUMAB ; NETWORK ; STATINS ; LIVER
摘要	Proprotein convertase subtilisin/kexin type 9 (PCSK9) has attracted lots of attention in preventing the clearance of plasma low-density lipoprotein cholesterol (LDL-C). PCSK9 inhibitors are developed to primarily reduce the cardiovascular risk by lowering LDL-C level. Recently, a number of pleiotropic extrahepatic functions of PCSK9 beyond the regulation of cholesterol metabolism, particularly its effects on central nervous system (CNS) diseases have been increasingly identified. Emerging clinical evidence have revealed that PCSK9 may play a significant role in neurocognition, depression, Alzheimer's disease, and stroke. The focus of this review is to elucidate the functions of PCSK9 and highlight the effects of PCSK9 in CNS diseases, with the aim of identifying the potential risks that may arise from low PCSK9 level (variant or inhibitor) in the clinical practice.
资助项目	Medical Health Science and Technology Project of Zhejiang Provincial Health Commission[2022KY1022];Zhejiang Provincial Natural Science Foundation of China[LYY19H280006];Zhejiang Provincial Natural Science Foundation of China[LQ21H310004];Zhejiang Provincial Science Technology Projects of Traditional Chinese Medicine[2021ZB174]
出版者	WILEY
ISSN	0272-4391
EISSN	1098-2299
卷号	85 期号:1
DOI	10.1002/ddr.22131
页数	10
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001102286800001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	37943623
SCOPUSEID	2-s2.0-85176280836
通讯作者地址	[Jin, Liang-Yan]Department of Pharmacy,Xixi Hospital of Hangzhou,Hangzhou,310023,China
Scopus学科分类	Drug Discovery
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183807
专题	其他_附属平阳医院（平阳县人民医院）
通讯作者	Jin, Liang-Yan
作者单位	1.Department of Pharmacy,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,China; 2.Department of Pharmacy,Pingyang Hospital Affiliated to Wenzhou Medical University (The People's Hospital of Pingyang),Wenzhou,China; 3.Department of Pharmacy,Deqing People's Hospital,Huzhou,China; 4.Center for Clinical Pharmacy,Cancer Center,Department of Pharmacy,Zhejiang Provincial People's Hospital,Affiliated People's Hospital,Hangzhou Medical College,Hangzhou,China; 5.Department of Pharmacy,Affiliated Hangzhou Xixi Hospital,Zhejiang University School of Medicine,Hangzhou,China
推荐引用方式 GB/T 7714	Zhu, Xiao-Bin,Xu, Yao-Yao,Li, Liu-Cheng,et al. Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence[J]. Drug development research,2023,85(1).
APA	Zhu, Xiao-Bin., Xu, Yao-Yao., Li, Liu-Cheng., Sun, Jia-Bin., Wang, Yu-Zhen., ... & Jin, Liang-Yan. (2023). Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence. Drug development research, 85(1).
MLA	Zhu, Xiao-Bin,et al."Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence".Drug development research 85.1(2023).