Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China

doi:10.1186/s41043-023-00467-2

科研成果详情

题名	Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China
作者	Wu, Liping1; Lan, Yanqi 2; Yu, Ze1; Wang, Yanhong 2; Liao, Wei 2; Zhang, Guoqiang 1; Wang, Li 2
发表日期	2023-11-06
发表期刊	Journal of health, population, and nutrition 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Case–control study High manganese exposure area Manganese NAFLD
其他关键词	CIGARETTE-SMOKING ; ASSOCIATION ; RISK ; HYPERTENSION ; MANAGEMENT ; NAFLD
摘要	Manganese (Mn) deficiency and intoxication may affect nonalcoholic fatty liver disease (NAFLD) risk differently. We aimed to explore the association between blood Mn and NAFLD in an area with high Mn exposure in drinking water., We conducted a case-control study among 1407 patients with NAFLD and 1774 sex- and age-matched healthy controls in a physical examination population in Zhoushan hospital, Zhejiang province in China. We used the restricted cubic splines method to investigate the dose-response relationship. Logistic regression models were applied to determine the risk of NAFLD, and severity of NAFLD., The blood Mn concentration was higher in the NAFLD group than in the control group in women (16.1 ± 6.2 μg/L vs. 14.7 ± 6.4 μg/L, P = 0.022) and men (14.5 ± 6.3 μg/L vs. 13.6 ± 6.8 μg/L, P < 0.001). We found an inverted L shape relationship between blood Mn and NAFLD in both women and men. Compared to the lowest quartile, the adjusted odds ratio (OR) and 95% confidence interval (CI) of NAFLD for the highest quartile group was 1.646(1.222,2.217), 1.494(1.082,2.061), and 3.146(1.285,7.701) for the total population, men, and women. The positive relationship was only observed in those with fibrosis-4 score < 1.30 and normal alanine transaminase. Stratified analysis showed an interaction between smoking (P = 0.073), alcohol drinking (P = 0.013), and Mn, with a more prominent effect on the NAFLD in the never-smokers (OR = 2.153, 95% CI 1.408-3.290) and drinkers (OR = 2.596, 95% CI 1.608-4.191)., Higher blood Mn is associated with an elevated NAFLD risk in the high Mn exposure areas, especially in nonsmokers and drinkers. Further studies are needed to verify this result in the areas with high Mn exposure.
资助项目	Zhoushan Science and Technology Project[2018C11042];CAMS Innovation Fund for Medical Sciences (CIFMS)[2016-I2M-3-001]
出版者	BMC
ISSN	1606-0997
EISSN	2072-1315
卷号	42 期号:1
DOI	10.1186/s41043-023-00467-2
页数	9
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS记录号	WOS:001098392300001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	37926847
SCOPUSEID	2-s2.0-85175809570
通讯作者地址	[Zhang, Guoqiang]Department of Hepatobiliary Surgery,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,316021,China ; [Wang, Li]Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking,Union Medical College,5 Dong Dan San Tiao,Beijing,100730,China
Scopus学科分类	Food Science;Public Health, Environmental and Occupational Health;Health, Toxicology and Mutagenesis
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183760
专题	其他_附属舟山医院（舟山医院）
通讯作者	Zhang, Guoqiang; Wang, Li
作者单位	1.Department of Hepatobiliary Surgery,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,316021,China; 2.Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking,Union Medical College,5 Dong Dan San Tiao,Beijing,100730,China
第一作者单位	其他_附属舟山医院（舟山医院）
通讯作者单位	其他_附属舟山医院（舟山医院）
第一作者的第一单位	其他_附属舟山医院（舟山医院）
推荐引用方式 GB/T 7714	Wu, Liping,Lan, Yanqi,Yu, Ze,et al. Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China[J]. Journal of health, population, and nutrition,2023,42(1).
APA	Wu, Liping., Lan, Yanqi., Yu, Ze., Wang, Yanhong., Liao, Wei., ... & Wang, Li. (2023). Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China. Journal of health, population, and nutrition, 42(1).
MLA	Wu, Liping,et al."Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China".Journal of health, population, and nutrition 42.1(2023).