[Effects of preoperative quetiapine on postoperative delirium and sleep quality in elderly orthopaedic patients]

doi:10.3760/cma.j.cn112137-20230719-00029

科研成果详情

题名	[Effects of preoperative quetiapine on postoperative delirium and sleep quality in elderly orthopaedic patients]
其他题名	Effects of preoperative quetiapine on postoperative delirium and sleep quality in elderly orthopaedic patients
作者	Y P Yang 1; Y Y Ding 1; Y Y Wang 1; W W Wang 2; K P Ye 2; Q G Ye 2; J Li 3
发表日期	2023-11-07
发表期刊	Zhonghua yi xue za zhi 影响因子和分区
语种	中文
原始文献类型	English Abstract ; Journal Article
关键词	Aged Osteopathic Postoperative delirium Quetiapine
其他关键词	Aged ; Osteopathic ; Postoperative delirium ; Quetiapine
摘要	Objective: To investigate the effects of preoperative quetiapine on postoperative delirium (POD) and sleep quality in elderly orthopedic patients. Methods: Prospectively, 111 elderly patients, American Society of Anesthesiologists (ASA) grade Ⅱ-Ⅲ, scheduled to undergo knee or hip surgery in the Affiliated Huangyan Hospital of Wenzhou Medical University under continuous spinal anesthesia from August 2021 to March 2023, were selected and randomly divided into two groups by random number table: control group (group C, 1 h preoperative placebo) and quetiapine group (group Q, 1 h preoperative quetiapine 12.5 mg). In group C, 54 cases were enrolled, including 25 males and 29 females, with an average age of (73.5±4.9) years. In group Q, 57 cases were enrolled, including 26 males and 31 females, with an average age of (74.8±5.0) years. The primary outcome measures were the incidence of POD evaluated by using confusion assessment method (CAM) at 24, 48, and 72 hours after surgery, and the secondary outcome measures included Pittsburgh sleep quality index (PSQI) scores at 24 and 48 hours after surgery and satisfaction of pain management within 24 hours after surgery. Results: The incidence of POD at 24, 48, and 72 h after surgery in group Q was 5.4% (3/57), 12.5% (7/57), 14.3% (8/57), respectively, while that in group C was 18.2% (10/54), 21.8% (12/54), 21.8% (12/54), respectively. The incidence of POD at 24 h after surgery in group Q was lower than that in group C (P=0.036). There was no significant difference in the incidence of POD at 48 and 72 h after surgery between two groups (all P>0.05). The PSQI score of patients in group Q at 24 and 48 h after surgery were (3.8±1.2) and (6.9±1.1) scores, respectively, which in group C were (10.5±2.8) and (7.3±1.3) scores, respectively. Compared with group C, the PSQI score of patients in group Q at 24 h after surgery was significantly higher (P<0.001), but there was no significant difference at 48 h after surgery (P=0.068). The satisfaction scores of pain management at 24 h after surgery in group Q was (91±7) scores, which was higher than that in group C of (81±6) scores (P<0.001). Conclusion: Oral intake of low-dose quetiapine 1 h preoperatively can reduce the incidence of POD, improve postoperative sleep quality and enhance postoperative satisfaction of pain management at 24 hours after surgery in elderly orthopedic patients undergoing knee or hip surgery
其他摘要	Objective:To investigate the effects of preoperative quetiapine on postoperative delirium (POD) and sleep quality in elderly orthopedic patients.Methods:Prospectively, 111 elderly patients, American Society of Anesthesiologists (ASA) grade Ⅱ-Ⅲ, scheduled to undergo knee or hip surgery in the Affiliated Huangyan Hospital of Wenzhou Medical University under continuous spinal anesthesia from August 2021 to March 2023, were selected and randomly divided into two groups by random number table: control group (group C, 1 h preoperative placebo) and quetiapine group (group Q, 1 h preoperative quetiapine 12.5 mg). In group C, 54 cases were enrolled, including 25 males and 29 females, with an average age of (73.5±4.9) years. In group Q, 57 cases were enrolled, including 26 males and 31 females, with an average age of (74.8±5.0) years. The primary outcome measures were the incidence of POD evaluated by using confusion assessment method (CAM) at 24, 48, and 72 hours after surgery, and the secondary outcome measures included Pittsburgh sleep quality index (PSQI) scores at 24 and 48 hours after surgery and satisfaction of pain management within 24 hours after surgery.Results:The incidence of POD at 24, 48, and 72 h after surgery in group Q was 5.4% (3/57), 12.5% (7/57), 14.3% (8/57), respectively, while that in group C was 18.2% (10/54), 21.8% (12/54), 21.8% (12/54), respectively. The incidence of POD at 24 h after surgery in group Q was lower than that in group C ( P=0.036). There was no significant difference in the incidence of POD at 48 and 72 h after surgery between two groups (all P0.05). The PSQI score of patients in group Q at 24 and 48 h after surgery were (3.8±1.2) and (6.9±1.1) scores, respectively, which in group C were (10.5±2.8) and (7.3±1.3) scores, respectively. Compared with group C, the PSQI score of patients in group Q at 24 h after surgery was significantly higher ( P<0.001), but there was no significant difference at 48 h after surgery ( P=0.068). The satisfaction scores of pain management at 24 h after surgery in group Q was (91±7) scores, which was higher than that in group C of (81±6) scores ( P<0.001). Conclusion:Oral intake of low-dose quetiapine 1 h preoperatively can reduce the incidence of POD, improve postoperative sleep quality and enhance postoperative satisfaction of pain management at 24 hours after surgery in elderly orthopedic patients undergoing knee or hip surgery.
资助项目	Medical and Health Technology Platform Project of Zhejiang Province[2021KY1208];
ISSN	0376-2491
卷号	103 期号:41 页码:3252-3257
DOI	10.3760/cma.j.cn112137-20230719-00029
页数	6
收录类别	PUBMED ; SCOPUS ; 万方 ; CSCD ; ISTIC ; 北大核心
URL	查看原文
PubMed ID	37926567
SCOPUSEID	2-s2.0-85176499413
通讯作者地址	[Li, Jun]Department of Anesthesiology,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183757
专题	附属第二医院_麻醉科附属第一医院_麻醉科
作者单位	1.Department of Anesthesiology, Affiliated Huangyan Hospital of Wenzhou Medical University, Taizhou 318020, China Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.; 2.Department of Anesthesiology, Affiliated Huangyan Hospital of Wenzhou Medical University, Taizhou 318020, China.; 3.Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
第一作者单位	附属第二医院_麻醉科
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	附属第二医院_麻醉科
推荐引用方式 GB/T 7714	Y P Yang,Y Y Ding,Y Y Wang,et al. [Effects of preoperative quetiapine on postoperative delirium and sleep quality in elderly orthopaedic patients][J]. Zhonghua yi xue za zhi,2023,103(41):3252-3257.
APA	Y P Yang., Y Y Ding., Y Y Wang., W W Wang., K P Ye., ... & J Li. (2023). [Effects of preoperative quetiapine on postoperative delirium and sleep quality in elderly orthopaedic patients]. Zhonghua yi xue za zhi, 103(41), 3252-3257.
MLA	Y P Yang,et al."[Effects of preoperative quetiapine on postoperative delirium and sleep quality in elderly orthopaedic patients]".Zhonghua yi xue za zhi 103.41(2023):3252-3257.