Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison With Invasive Non-Mucinous Adenocarcinoma

doi:10.1177/10668969231209784

科研成果详情

题名	Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison With Invasive Non-Mucinous Adenocarcinoma
作者	He, Hui 1; Li, Lue 2; Wen, Yuan-Yuan 1; Qian, Li-Yong 1; Yang, Zhi-Qiang 2
发表日期	2023-11-01
发表期刊	International journal of surgical pathology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	filigree pattern invasive mucinous adenocarcinoma of the lung micropapillary pattern tumor spread through air space (STAS)
其他关键词	IASLC/ATS/ERS CLASSIFICATION ; TUMOR SPREAD ; CARCINOMA ; BREAST ; IMPACTS
摘要	Background. The presence of a micropapillary pattern is associated with poor outcomes in lung adenocarcinoma. This study aimed to assess the clinicopathological features of micropapillary pattern in mucinous adenocarcinoma of the lung. Methods. The patients were stratified into three groups: the invasive mucinous adenocarcinoma group (60 patients), the mixed invasive mucinous adenocarcinoma group (33 patients), and the invasive non-mucinous adenocarcinoma group (237 patients). The presence of micropapillary pattern and its clinicopathological features were analyzed and compared between the three groups. Results. Compared to mixed invasive mucinous adenocarcinoma, invasive mucinous adenocarcinoma had lower frequencies of micropapillary pattern (28.3% vs 87.9%, respectively; P < .001) and lymph node metastasis (00.0% vs 15.1%, respectively; P = .005). The frequency of tumor spread through air space (STAS) in invasive mucinous adenocarcinoma (23.3%) was higher than that in invasive non-mucinous adenocarcinoma (6.3%; P < .001), while lower than that in mixed invasive mucinous adenocarcinoma (60.6%; P < .001). When the three groups were all accompanied by micropapillary pattern, there was no obvious difference in STAS between invasive mucinous adenocarcinoma with micropapillary pattern and mixed mucinous adenocarcinoma with micropapillary pattern (P > .05). No filigree pattern occurred in invasive mucinous adenocarcinoma with micropapillary pattern. Conclusions. The micropapillary pattern is frequently observed in invasive mucinous adenocarcinoma and has a better prognosis compared to mixed invasive mucinous adenocarcinoma and invasive non-mucinous adenocarcinoma. However, the malignancy of the micropapillary pattern in mixed mucinous adenocarcinoma was similar to that in invasive non-mucinous adenocarcinoma, even with the presence of mucus. These findings suggest that the development mechanisms of the micropapillary pattern in invasive mucinous adenocarcinoma and mixed mucinous adenocarcinoma may differ
出版者	SAGE PUBLICATIONS INC
ISSN	1066-8969
EISSN	1940-2465
卷号	32 期号:5 页码:926-934
DOI	10.1177/10668969231209784
页数	9
WOS类目	Pathology ; Surgery
WOS研究方向	Pathology ; Surgery
WOS记录号	WOS:001095973100001
收录类别	PUBMED ; SCOPUS ; SCIE
在线发表日期	2023-11
URL	查看原文
PubMed ID	37915205
SCOPUSEID	2-s2.0-85175692820
通讯作者地址	[Yang, Zhi-Qiang]Department of Respiratory Medicine,Zhoushan Hospital,Wenzhou Medical University,Zhejiang Province,Zhoushan City,China
Scopus学科分类	Surgery;Anatomy;Pathology and Forensic Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183733
专题	其他_附属舟山医院（舟山医院）
通讯作者	Yang, Zhi-Qiang
作者单位	1.Department of Pathology,Zhoushan Hospital,Wenzhou Medical University,Zhejiang Province,Zhoushan City,China; 2.Department of Respiratory Medicine,Zhoushan Hospital,Wenzhou Medical University,Zhejiang Province,Zhoushan City,China
第一作者单位	其他_附属舟山医院（舟山医院）
通讯作者单位	其他_附属舟山医院（舟山医院）
第一作者的第一单位	其他_附属舟山医院（舟山医院）
推荐引用方式 GB/T 7714	He, Hui,Li, Lue,Wen, Yuan-Yuan,et al. Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison With Invasive Non-Mucinous Adenocarcinoma[J]. International journal of surgical pathology,2023,32(5):926-934.
APA	He, Hui, Li, Lue, Wen, Yuan-Yuan, Qian, Li-Yong, & Yang, Zhi-Qiang. (2023). Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison With Invasive Non-Mucinous Adenocarcinoma. International journal of surgical pathology, 32(5), 926-934.
MLA	He, Hui,et al."Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison With Invasive Non-Mucinous Adenocarcinoma".International journal of surgical pathology 32.5(2023):926-934.