The relationship between gut microbiota, short-chain fatty acids, and glucolipid metabolism in pregnant women with large for gestational age infants

doi:10.1093/jambio/lxad240

科研成果详情

题名	The relationship between gut microbiota, short-chain fatty acids, and glucolipid metabolism in pregnant women with large for gestational age infants
作者	Lan, Yehui1; Pan, Shuangjia1; Chen, Baoyi1; Zhou, Feifei2; Yang, Fan 3,4,5; Chao, Shan 5; Hua, Ying 1; Liu, Haibin1
发表日期	2023-11-01
发表期刊	Journal of applied microbiology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Article
关键词	appropriate for gestational age glucolipid metabolism gut microbiota composition large for gestational age short-chain fatty acids
其他关键词	WEIGHT-GAIN ; CORD BLOOD ; C-PEPTIDE ; GLUCOSE ; INSULIN ; ASSOCIATIONS ; TRIGLYCERIDE ; LIPIDS ; BIRTH ; RISK
摘要	To elucidate the association between gut microbiota, short-chain fatty acids (SCFAs), and glucolipid metabolism in women with large for gestational age (LGA) infants., A single-center, observational prospective cohort study was performed at a tertiary hospital in Wenzhou, China. Normal pregnant women were divided into LGA group and appropriate for gestational age (AGA) group according to the neonatal birth weight. Fecal samples were collected from each subject before delivery for the analysis of gut microbiota composition (GMC) and SCFAs. Blood samples were obtained at 24-28 weeks of gestation age to measure fasting blood glucose and fasting insulin levels, as well as just before delivery to assess serum triglycerides, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein. The GMC exhibited differences at various taxonomic levels. Within the Firmicutes phylum, genus Lactobacillus, genus Clostridium, species Lactobacillus agil, and species Lactobacillus salivarius were enriched in the LGA group. Microbispora at genus level, Microbispora rosea at species level belonging to the Actinobacteria phylum, Neisseriales at order level, Bartonellaceae at family level, Paracoccus aminovorans, and Methylobacterium at genus level from the Proteobacteria phylum were more abundant in the LGA group. In contrast, within the Bacteroidetes phylum, Prevotella at genus level and Parabacteroides distasonis at species level were enriched in the AGA group. Although there were few differences observed in SCFA levels and most glucolipid metabolism indicators between the two groups, the serum HDL level was significantly lower in the LGA group compared to the AGA group. No significant relevance among GMC, SCFAs, and glucolipid metabolism indicators was found in the LGA group or in the AGA group., Multiple different taxa, especially phylum Firmicutes, genus Prevotella, and genus Clostridium, might play an important role in excessive fetal growth, and LGA might be associated with the lower serum HDL level.
资助项目	Lin He's Academician Workstation of New Medicine and Clinical Translation[18331201];Obstetrics and Gynecology of Combine traditional Chinese and Western Medicine of Zhejiang Province[2017-XK-A42]
出版者	OXFORD UNIV PRESS
ISSN	1364-5072
EISSN	1365-2672
卷号	134 期号:11
DOI	10.1093/jambio/lxad240
页数	12
WOS类目	Biotechnology & Applied Microbiology ; Microbiology
WOS研究方向	Biotechnology & Applied Microbiology ; Microbiology
WOS记录号	WOS:001101068800002
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	37883533
SCOPUSEID	2-s2.0-85176973825
通讯作者地址	[Hua, Ying]Department of Obstetrics and Gynecology and General Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325027,China ; [Liu, Haibin]Department of Obstetrics and Gynecology and General Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Biotechnology;Applied Microbiology and Biotechnology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183694
专题	第二临床医学院，附属第二医院、育英儿童医院附属第二医院其他_温州市第三临床学院（温州市人民医院）
通讯作者	Hua, Ying; Liu, Haibin
作者单位	1.Department of Obstetrics and Gynecology and General Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325027,China; 2.Department of Obstetrics and Gynecology,The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou,325027,China; 3.Key Laboratory of Cell Engineering in Guizhou Province,Affiliated Hospital of Zunyi Medical University,Zunyi,563000,China; 4.Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education),Shanghai Jiao Tong University,Shanghai,200240,China; 5.Research Center for Lin He Academician New Medicine,Institutes for Shanghai Pudong Decoding Life,Shanghai,2000240,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
推荐引用方式 GB/T 7714	Lan, Yehui,Pan, Shuangjia,Chen, Baoyi,et al. The relationship between gut microbiota, short-chain fatty acids, and glucolipid metabolism in pregnant women with large for gestational age infants[J]. Journal of applied microbiology,2023,134(11).
APA	Lan, Yehui., Pan, Shuangjia., Chen, Baoyi., Zhou, Feifei., Yang, Fan., ... & Liu, Haibin. (2023). The relationship between gut microbiota, short-chain fatty acids, and glucolipid metabolism in pregnant women with large for gestational age infants. Journal of applied microbiology, 134(11).
MLA	Lan, Yehui,et al."The relationship between gut microbiota, short-chain fatty acids, and glucolipid metabolism in pregnant women with large for gestational age infants".Journal of applied microbiology 134.11(2023).