题名 | Identification and Characterization of CD8+ CD27+ CXCR3- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus |
作者 | |
发表日期 | 2023-10-24 |
发表期刊 | Advanced science (Weinheim, Baden-Wurttemberg, Germany) 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Journal Article |
关键词 | dynamic network biomarker mass cytometry single-cell RNA sequencing systemic lupus erythematosus |
摘要 | Systemic Lupus Erythematosus (SLE) etiopathogenesis highlights the contributions of overproduction of CD4+ T cells and loss of immune tolerance. However, the involvement of CD8+ T cells in SLE pathology and disease progression remains unclear. Here, the comprehensive immune cell dysregulation in total 263 clinical peripheral blood samples composed of active SLE (aSLE), remission SLE (rSLE) and healthy controls (HCs) is investigated via mass cytometry, flow cytometry and single-cell RNA sequencing. This is observed that CD8+ CD27+ CXCR3- T cells are increased in rSLE compare to aSLE. Meanwhile, the effector function of CD8+ CD27+ CXCR3- T cells are overactive in aSLE compare to HCs and rSLE, and are positively associated with clinical SLE activity. In addition, the response of peripheral blood mononuclear cells (PBMCs) is monitored to interleukin-2 stimulation in aSLE and rSLE to construct dynamic network biomarker (DNB) model. It is demonstrated that DNB score-related parameters can faithfully predict the remission of aSLE and the flares of rSLE. The abundance and functional dysregulation of CD8+ CD27+ CXCR3- T cells can be potential biomarkers for SLE prognosis and concomitant diagnosis. The DNB score with accurate prediction to SLE disease progression can provide clinical treatment suggestions especially for drug dosage determination |
资助项目 | National Key R&D Program of China[2022YFA1004800];National Key R&D Program of China[2022YFC2601700];National Natural Science Foundation of China[T2122002];National Natural Science Foundation of China[22077079];National Natural Science Foundation of China[81871448];National Natural Science Foundation of China[31930022];National Natural Science Foundation of China[12131020];National Natural Science Foundation of China[T2341007];National Natural Science Foundation of China[T2350003];Shanghai Municipal Science and Technology Projects[22Z510202478];Shanghai Municipal Science and Technology Projects[23YF1425600];Shanghai Municipal Science and Technology Projects[18430760500];Shanghai Municipal Science and Technology Projects[2017SHZDZX01];Shanghai Municipal Education Commission Projects[21SG10];Shanghai Municipal Education Commission Projects[ZXWF082101];Shanghai Jiao Tong University Projects[YG2019ZDA20];Shanghai Jiao Tong University Projects[YG2021ZD19];Shanghai Jiao Tong University Projects[Agri-X20200101];Shanghai Jiao Tong University Projects[2020SJTU-HUJI];Shanghai Jiao Tong University Projects[23X010300584];Shanghai Municipal Health Commission Project[2019CXJQ03];Shanghai Clinical Medical Research Center Project[19MC1910800];Shanghai Sailing Program[20YF1425800];JST Moonshot R&D[JPMJMS2021] |
出版者 | John Wiley and Sons Inc |
ISSN | 2198-3844 |
EISSN | 2198-3844 |
卷号 | 10期号:35 |
DOI | 10.1002/advs.202300123 |
收录类别 | PUBMED ; EI ; SCOPUS |
EI入藏号 | 20234314949151 |
EI主题词 | RNA |
EI分类号 | 461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 461.9.1 Immunology |
URL | 查看原文 |
PubMed ID | 37875396 |
SCOPUSEID | 2-s2.0-85174567583 |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/183679 |
专题 | 附属第一医院_风湿免疫科 |
作者单位 | 1.Department of Rheumatology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital and School of Biomedical Engineering, Shanghai, 200030, China.; 2.State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200001, China.; 3.Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.; 4.University of Chinese Academy of Sciences, Beijing, 100049, China.; 5.School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; 6.Department of Rheumatology and Immunology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.; 7.Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, 17121, Sweden.; 8.Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.; 9.Drug Discovery, Shanghai Huaota Biopharmaceutical Co. Ltd., Shanghai, 200131, China.; 10.Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, Nantong Hospital of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine.; 11.Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, 310024, China. |
推荐引用方式 GB/T 7714 | Lulu Zhang,Fang Du,Qiqi Jin,et al. Identification and Characterization of CD8+ CD27+ CXCR3- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus[J]. Advanced science (Weinheim, Baden-Wurttemberg, Germany),2023,10(35). |
APA | Lulu Zhang., Fang Du., Qiqi Jin., Li Sun., Boqian Wang., ... & Xianting Ding. (2023). Identification and Characterization of CD8+ CD27+ CXCR3- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(35). |
MLA | Lulu Zhang,et al."Identification and Characterization of CD8+ CD27+ CXCR3- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus".Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10.35(2023). |
条目包含的文件 | 条目无相关文件。 |
个性服务 |
查看访问统计 |
谷歌学术 |
谷歌学术中相似的文章 |
[Lulu Zhang]的文章 |
[Fang Du]的文章 |
[Qiqi Jin]的文章 |
百度学术 |
百度学术中相似的文章 |
[Lulu Zhang]的文章 |
[Fang Du]的文章 |
[Qiqi Jin]的文章 |
必应学术 |
必应学术中相似的文章 |
[Lulu Zhang]的文章 |
[Fang Du]的文章 |
[Qiqi Jin]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论