Prevalence, Risk Factors, and Clinical Outcomes of New Cerebral Microbleeds After Intravenous Thrombolysis in Acute Ischemic Stroke: a Systematic Review and Meta-analysis

doi:10.1007/s00062-023-01357-0

科研成果详情

题名	Prevalence, Risk Factors, and Clinical Outcomes of New Cerebral Microbleeds After Intravenous Thrombolysis in Acute Ischemic Stroke: a Systematic Review and Meta-analysis
作者	Zhenxiang Zhan 1; Fangwang Fu2; Wenyuan Zhang 3; Zicheng Cheng 4
发表日期	2023-10-19
发表期刊	Clinical neuroradiology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Acute ischemic stroke Cerebral microbleeds Intravenous thrombolysis Prognosis
摘要	Cerebral microbleeds (CMBs) are common in the elderly population, and are associated with an increased risk of stroke and dementia. An acute ischemic stroke event can make CMBs develop rapidly. However, the progression of CMBs after intravenous thrombolysis is not well understood., Following a previously registered protocol, PubMed, Web of Science, and Embase databases were systematically searched to identify relevant literature up to August 2022. Cohort studies that reported new CMBs in patients with acute ischemic stroke undergoing intravenous thrombolysis were included. Random effects models were used to calculate the pooled estimates., Seven studies with 1079 patients were included in the meta-analysis. The pooled new CMBs prevalence was 7.6% (95% CI 3.9-14.3%) and 63.6% new CMBs were located in the cerebral lobes. Compared with patients without new CMBs, those with new CMBs were older, had a higher proportion of hypertension, and had higher systolic blood pressure and baseline CMBs burden. The presence of new CMBs increased the likelihood of remote intracerebral hemorrhage (OR 28.75, 95% CI 8.58-96.38) and symptomatic intracerebral hemorrhage (OR 15.49, 95% CI 3.21-74.73) but was not related to functional outcomes or hemorrhagic transformation., The prevalence of new CMBs after intravenous thrombolysis was approximately 7.6%. The presence of new CMBs is associated with remote and symptomatic intracerebral hemorrhage following intravenous thrombolysis. Considering the potential long-term adverse effects of CMBs progression, patients at a high risk of developing new CMBs should be identified based on potential risk factors.
ISSN	1869-1439
EISSN	1869-1447
DOI	10.1007/s00062-023-01357-0
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37857916
SCOPUSEID	2-s2.0-85174493913
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183650
专题	第二临床医学院，附属第二医院、育英儿童医院_神经病学_神经内科其他_附属乐清医院（乐清市人民医院）
作者单位	1.Department of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.; 2.Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; 3.Department of Neurology, Affiliated Yueqing Hospital, Wenzhou Medical University, Yueqing, China.; 4.Department of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China. cheng_1712@163.com.
推荐引用方式 GB/T 7714	Zhenxiang Zhan,Fangwang Fu,Wenyuan Zhang,et al. Prevalence, Risk Factors, and Clinical Outcomes of New Cerebral Microbleeds After Intravenous Thrombolysis in Acute Ischemic Stroke: a Systematic Review and Meta-analysis[J]. Clinical neuroradiology,2023.
APA	Zhenxiang Zhan, Fangwang Fu, Wenyuan Zhang, & Zicheng Cheng. (2023). Prevalence, Risk Factors, and Clinical Outcomes of New Cerebral Microbleeds After Intravenous Thrombolysis in Acute Ischemic Stroke: a Systematic Review and Meta-analysis. Clinical neuroradiology.
MLA	Zhenxiang Zhan,et al."Prevalence, Risk Factors, and Clinical Outcomes of New Cerebral Microbleeds After Intravenous Thrombolysis in Acute Ischemic Stroke: a Systematic Review and Meta-analysis".Clinical neuroradiology (2023).