科研成果详情

题名Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma
作者
发表日期2023-10-03
发表期刊ACS OMEGA   影响因子和分区
语种英语
原始文献类型Article
其他关键词COMPREHENSIVE ANALYSIS ; CELL-DEATH ; COPPER ; CANCER ; SIGNATURES ; APOPTOSIS ; SYSTEMS
摘要

The crucial role of competitive endogenous RNA (ceRNA) in the malignant biological behavior of tumors has been certificated. Nevertheless, the detailed function and molecular mechanism of ceRNA associated with cuproptosis in hepatocellular carcinoma (HCC) remains dismal. In this study, we first constructed a protein-protein interaction network and identified the module with the highest degree of aggregation degree. DLAT and PDHA1 were screened out of the module after differential expression and survival analysis. Next, we reverse-predicted the upstream miRNA and lncRNA from mRNA (DLAT, PDHA1) and successfully established the ceRNA network-SNHG3/miR-1306-5p/PDHA1. SNHG3 was identified to be an independent prognostic biomarker based on the outcome of univariate and multivariate Cox analyses. Subsequently, we implemented methylation, immune infiltration, and drug sensitivity analysis to investigate the potential biological functions of SNHG3 in HCC. In addition, SNHG3 expression was upregulated in liver cancer cell lines. In vitro functional assay revealed that SNHG3 knockdown significantly attenuated proliferation, migration, and invasion of liver cancer cells. In summary, SNHG3 exhibited oncogenic characterization via sponging miR-1306-5p to regulate PDHA1, which might function as a promising prognostic indicator and a potential therapeutic target for HCC and shed new light on the molecular mechanism of HCC progression.

资助项目Zhejiang Province Major Science and Technology Project for Medicine and Health [WKJ-ZJ-2329] ; General Scientific Research Project of Zhejiang Provincial Education Department [Y202250086]
出版者AMER CHEMICAL SOC
ISSN2470-1343
卷号8期号:41页码:38690-38703
DOI10.1021/acsomega.3c06018
页数14
WOS类目Chemistry, Multidisciplinary
WOS研究方向Chemistry
WOS记录号WOS:001077702500001
收录类别SCIE ; PUBMED ; SCOPUS
在线发表日期2023-10
URL查看原文
发表状态已发表
PubMed ID37867671
SCOPUSEID2-s2.0-85176142633
通讯作者地址[Li, Shibo]Department of Infectious Disease,Zhoushan Hospital,Wenzhou Medical University,739 Dingshen Rd,Zhoushan City,316021,China
Scopus学科分类Chemistry (all);Chemical Engineering (all)
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/183584
专题其他_附属舟山医院(舟山医院)
通讯作者Li, Shibo
作者单位
1.Department of Infectious Disease,Zhoushan Hospital,Wenzhou Medical University,739 Dingshen Rd,Zhoushan City,316021,China;
2.State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,79 Qingchun Rd.,Hangzhou City,310003,China
第一作者单位其他_附属舟山医院(舟山医院)
通讯作者单位其他_附属舟山医院(舟山医院)
第一作者的第一单位其他_附属舟山医院(舟山医院)
推荐引用方式
GB/T 7714
Pan, Yong,Zhang, Yiru,Hu, Xiaodan,et al. Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma[J]. ACS OMEGA,2023,8(41):38690-38703.
APA Pan, Yong, Zhang, Yiru, Hu, Xiaodan, & Li, Shibo. (2023). Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma. ACS OMEGA, 8(41), 38690-38703.
MLA Pan, Yong,et al."Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma".ACS OMEGA 8.41(2023):38690-38703.

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