Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder

doi:10.1111/adb.13348

科研成果详情

题名	Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder
作者	Xu, Hui1,2; Xu, Cheng 3; Guo, Yunyu1; Hu, Yike1; Bai, Guanghui1; Du, Meimei1
发表日期	2023
发表期刊	ADDICTION BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	anatomical alterations cocaine use disorder cortical thickness diagnostic biomarkers surface-based morphometry
其他关键词	CORTICAL THICKNESS ; TRAIT IMPULSIVITY ; MATTER VOLUME ; SURFACE-AREA ; BRAIN ; ADDICTION ; INSULA ; DEPENDENCE ; VULNERABILITY ; MECHANISMS
摘要	Cocaine use disorder (CUD) is a global health problem with serious consequences for both individuals and society. Previous studies on abnormal anatomical patterns in CUD have mainly used voxel-based morphometry to investigate grey matter volume changes, while surface-based morphometry (SBM) has been found to provide detail information on cortical thickness (CT), surface area and cortical meancurve, which can contribute to a better understanding of structural brain changes associated with CUD. In this study, SBM was conducted to investigate abnormal neuroanatomical patterns in CUD and whether these abnormal patterns could be used as potential diagnostic biomarkers for CUD. Sixty-eight CUD individuals and 52 matched healthy controls were enrolled, and all participants performed once MRI scanning and clinical assessments. We found that CUD individuals exhibited altered morphological indicators across widespread brain regions and these abnormal anatomical alterations were significantly predictive of CUD status. Furthermore, the CT reduction of right insula was significantly associated with years of cocaine use in CUD. These findings revealed the association of abnormal anatomical patterns in specific brain regions in CUD, which further improve the understanding of CUD pathophysiology and provide the alternative diagnostic biomarkers for CUD. Cocaine use disorder (CUD) individuals exhibited altered morphological indicators across widespread cortical regions. The abnormal anatomical alterations were significantly predictive of CUD status. Furthermore, cortical thickness reduction of the right insular cortex was significantly associated with years of cocaine. image
资助项目	We thank the OpenNEURO database () for sharing this dataset for this study. This study was funded by the Natural Science Foundation of Zhejiang Province (No. LTGY23H180011), and Medical Health Science and Technology Project of Zhejiang Provincial Health Co [LTGY23H180011]; Natural Science Foundation of Zhejiang Province [2023KY91]; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission
出版者	WILEY
ISSN	1355-6215
EISSN	1369-1600
卷号	28 期号:11
DOI	10.1111/adb.13348
页数	10
WOS类目	Biochemistry & Molecular Biology ; Substance Abuse
WOS研究方向	Biochemistry & Molecular Biology ; Substance Abuse
WOS记录号	WOS:001081037200001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	3785507
SCOPUSEID	2-s2.0-85173812890
通讯作者地址	[Xu, Hui]School of Mental Health,Wenzhou Medical University,Wenzhou,325035,China ; [Bai, Guanghui]Department of Radiology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China ; [Du, Meimei]Department of Radiology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Medicine (miscellaneous);Pharmacology;Psychiatry and Mental Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183583
专题	第二临床医学院，附属第二医院、育英儿童医院精神医学学院
通讯作者	Xu, Hui; Bai, Guanghui; Du, Meimei
作者单位	1.Department of Radiology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of Mental Health,Wenzhou Medical University,Wenzhou,China; 3.School of Psychology and Cognitive Science,East China Normal University,Shanghai,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 精神医学学院
通讯作者单位	精神医学学院; 第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Xu, Hui,Xu, Cheng,Guo, Yunyu,et al. Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder[J]. ADDICTION BIOLOGY,2023,28(11).
APA	Xu, Hui, Xu, Cheng, Guo, Yunyu, Hu, Yike, Bai, Guanghui, & Du, Meimei. (2023). Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder. ADDICTION BIOLOGY, 28(11).
MLA	Xu, Hui,et al."Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder".ADDICTION BIOLOGY 28.11(2023).