The relationship between cancer and biomechanics

doi:10.3389/fonc.2023.1273154

科研成果详情

题名	The relationship between cancer and biomechanics
作者	Bao, Liqi 1,2; Kong, Hongru1; Ja, Yang 1,3; Wang, Chengchao 1,3; Qin, Lei 4; Sun, Hongwei1; Dai, Shengjie1,4
发表日期	2023-10-12
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	cancer biomechanics tumor microenvironment metastasis invasion
其他关键词	CARCINOMA IN-SITU ; MECHANICAL FORCES ; COLLAGEN MATRICES ; CELL MECHANICS ; TUMOR-GROWTH ; REVEALS ; MECHANOTRANSDUCTION ; MICROENVIRONMENT ; DEFORMABILITY ; DEFINITIONS
摘要	The onset, development, diagnosis, and treatment of cancer involve intricate interactions among various factors, spanning the realms of mechanics, physics, chemistry, and biology. Within our bodies, cells are subject to a variety of forces such as gravity, magnetism, tension, compression, shear stress, and biological static force/hydrostatic pressure. These forces are perceived by mechanoreceptors as mechanical signals, which are then transmitted to cells through a process known as mechanical transduction. During tumor development, invasion and metastasis, there are significant biomechanical influences on various aspects such as tumor angiogenesis, interactions between tumor cells and the extracellular matrix (ECM), interactions between tumor cells and other cells, and interactions between tumor cells and the circulatory system and vasculature. The tumor microenvironment comprises a complex interplay of cells, ECM and vasculature, with the ECM, comprising collagen, fibronectins, integrins, laminins and matrix metalloproteinases, acting as a critical mediator of mechanical properties and a key component within the mechanical signaling pathway. The vasculature exerts appropriate shear forces on tumor cells, enabling their escape from immune surveillance, facilitating their dissemination in the bloodstream, dictating the trajectory of circulating tumor cells (CTCs) and playing a pivotal role in regulating adhesion to the vessel wall. Tumor biomechanics plays a critical role in tumor progression and metastasis, as alterations in biomechanical properties throughout the malignant transformation process trigger a cascade of changes in cellular behavior and the tumor microenvironment, ultimately culminating in the malignant biological behavior of the tumor.
资助项目	The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from Basic Scientific Research Project of WenZhou Science and Technology Bureau (Y20210935), Youth Cultiv [Y20210935]; Basic Scientific Research Project of WenZhou Science and Technology Bureau; Youth Cultivation Project of National Clinical Key Specialty [WKJ-ZJ-2342]; Province-Ministry Joint Project In Zhejiang Province [19KJA170002]; Major Projects At Universities In JiangSu Province
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	13
DOI	10.3389/fonc.2023.1273154
页数	12
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001087235600001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37901315
SCOPUSEID	2-s2.0-85175048864
通讯作者地址	[Sun, Hongwei]Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Dai, Shengjie]Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Qin, Lei]Department of General Surgery,The First Affiliated Hospital of Soochow University,Jiangsu,Suzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183577
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院仁济学院
通讯作者	Qin, Lei; Sun, Hongwei; Dai, Shengjie
作者单位	1.Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Renji College,Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.The First Clinical Medical College,Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Department of General Surgery,The First Affiliated Hospital of Soochow University,Jiangsu,Suzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 仁济学院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Bao, Liqi,Kong, Hongru,Ja, Yang,et al. The relationship between cancer and biomechanics[J]. FRONTIERS IN ONCOLOGY,2023,13.
APA	Bao, Liqi., Kong, Hongru., Ja, Yang., Wang, Chengchao., Qin, Lei., ... & Dai, Shengjie. (2023). The relationship between cancer and biomechanics. FRONTIERS IN ONCOLOGY, 13.
MLA	Bao, Liqi,et al."The relationship between cancer and biomechanics".FRONTIERS IN ONCOLOGY 13(2023).