The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery

doi:10.21037/jgo-23-543

科研成果详情

题名	The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery
作者	Shen, Ningzhe 1; Wen, Jian2; Chen, Chenbin3; Chen, Xiaodong1; Zhang, Weiteng1; Garijo, Paula Domínguez 4; Wei, Matthew Yuan-Kun 5; Chen, Wenjing 1; Xue, Xiangyang2,3; Sun, Xiangwei1
发表日期	2023-09-28
发表期刊	JOURNAL OF GASTROINTESTINAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Global Leadership Initiative on Malnutrition (GLIM) elderly colorectal cancer (CRC) post-operative complications prognosis
其他关键词	DEFINED MALNUTRITION ; NUTRITIONAL RISK ; BODY-COMPOSITION ; SURVIVAL ; OUTCOMES
摘要	Background: Elderly people and patients with colorectal cancer (CRC) are both at high risk of malnutrition. Therefore, it is of great significance to explore suitable malnutrition screening and diagnostic indicators for elderly patients with CRC. Recently, the Global Leadership Initiative on Malnutrition (GLIM) proposed new diagnostic criteria for malnutrition. The aim of this article was to evaluate the diagnostic value of GLIM criteria for malnutrition in elderly colorectal patients. We explored the relationship between GLIM-malnutrition, post-operative complications and the long-term prognosis of elderly colorectal patients.Methods: Elderly patients (aged >= 65 years) who underwent CRC surgery from January 2015 to December 2018 were included. Malnutrition was diagnosed based on the GLIM criteria. The relationships between GLIM-malnutrition and clinical characteristics were analyzed by t-tests, Mann-Whitney U tests, and chi squared tests. The relationships between GLIM-malnutrition and post-operative complications were analyzed by chi-squared tests, and logistic regression analyses. The relationships between GLIM-malnutrition and the long-term prognosis were analyzed by Kaplan-Meier analyses and logistic and Cox regression analyses.Result: A total of 385 elderly patients were included in this study, and 118 patients (30.65%) were diagnosed with malnutrition according to the GLIM criteria. GLIM-malnutrition was significantly associated with older age, lower body mass index (BMI), lower grip strength, tumor location, higher NRS 2002, and lower levels of albumin and hemoglobin. GLIM-malnutrition was an independent risk factor [odd ratio (OR): 1.753, 95% confidence interval (CI): 1.100-2.795, P=0.018] for post-operative complications. Cox regression analysis showed that GLIM-malnutrition was an independent risk factor for overall survival in elderly patients with CRC.Conclusions: The GLIM criteria are feasible diagnostic criteria for malnutrition of elderly patients with CRC. GLIM-malnutrition is significantly associated with post-operative complications and overall survival in elderly patients with CRC.
资助项目	Health Commission of Zhejiang [2023RC203]
出版者	AME PUBLISHING COMPANY
ISSN	2078-6891
EISSN	2219-679X
卷号	14 期号:5 页码:2134-2145
DOI	10.21037/jgo-23-543
页数	11
WOS类目	Oncology ; Gastroenterology & Hepatology
WOS研究方向	Oncology ; Gastroenterology & Hepatology
WOS记录号	WOS:001077547100001
收录类别	SCIE ; SCOPUS ; PUBMED
在线发表日期	2023-09
URL	查看原文
PubMed ID	37969837
SCOPUSEID	2-s2.0-85177072184
通讯作者地址	[Xue, Xiangyang]Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research and Precision Medicine,Wenzhou Key Laboratory of Cancer-Related Pathogens and Immunity,Department of Microbiology and Immunology,Institute of Molecular Virology and Immunology,School of Basic Medical Sciences,Wenzhou Medical University,No. 270, Xueyuan West Road, Lucheng District,Wenzhou,32500,China ; [Sun, Xiangwei]Department of General Surgery,The First AffiliatedHospital of Wenzhou Medical University,Shangcai Village, Ouhai District,Wenzhou,32500,China
Scopus学科分类	Oncology;Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183540
专题	附属第一医院附属第二医院基础医学院（机能实验教学中心）_病原生物学与免疫学系
通讯作者	Xue, Xiangyang; Sun, Xiangwei
作者单位	1.Department of General Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research and Precision Medicine,Wenzhou Key Laboratory of Cancer-Related Pathogens and Immunity,Department of Microbiology and Immunology,Institute of Molecular Virology and Immunology,School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Department of General Surgery,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Gastrointestinal Surgery,Institute of Digestive and Metabolic Diseases,Hospital Clinic,University of Barcelona,Catalonia,Barcelona,Spain; 5.Department of Medicine,Dentistry and Health Sciences,University of Melbourne,Victoria,Australia
第一作者单位	附属第一医院
通讯作者单位	基础医学院（机能实验教学中心）_病原生物学与免疫学系; 温州医科大学
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Shen, Ningzhe,Wen, Jian,Chen, Chenbin,et al. The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery[J]. JOURNAL OF GASTROINTESTINAL ONCOLOGY,2023,14(5):2134-2145.
APA	Shen, Ningzhe., Wen, Jian., Chen, Chenbin., Chen, Xiaodong., Zhang, Weiteng., ... & Sun, Xiangwei. (2023). The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery. JOURNAL OF GASTROINTESTINAL ONCOLOGY, 14(5), 2134-2145.
MLA	Shen, Ningzhe,et al."The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery".JOURNAL OF GASTROINTESTINAL ONCOLOGY 14.5(2023):2134-2145.