The aspartate aminotransferase to alanine aminotransferase ratio: A novel indicator for skeletal muscle mass in Chinese community adults

doi:10.1016/j.nut.2023.112214

科研成果详情

题名	The aspartate aminotransferase to alanine aminotransferase ratio: A novel indicator for skeletal muscle mass in Chinese community adults
作者	Hong, Huisuo1; Jiang, Kewei 2; Ye, Huajun 2; Xue, Haibo3; Chen, Mengjun3
发表日期	2024-01
发表期刊	Nutrition (Burbank, Los Angeles County, Calif.) 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Aspartate aminotransferase to alanine aminotransferase ratio Chinese community adults Chronic liver disease Low skeletal muscle mass Sarcopenia Skeletal muscle mass index
其他关键词	ASIAN WORKING GROUP ; NONALCOHOLIC STEATOHEPATITIS ; LIVER FIBROSIS ; SARCOPENIA ; DIAGNOSIS ; DISEASE ; SCORE ; ROAD
摘要	The aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio, an indicator for liver fibrosis, could be easily detected in clinical practice. The aim of this study was to examine the association between the AST/ALT ratio and skeletal muscle mass among Chinese community adult residents., We enrolled 2644 participants, age ≥18 y, undergoing bioelectrical impedance analysis and liver function test. Univariate and multivariate logistic regression models were used to analyze the effect of the AST/ALT ratio on the presence of low muscle mass (LMM). Multiple linear regression analysis was used to assess the factors associated with the skeletal muscle mass index (SMI) and to construct a formula to calculate the SMI., {AbstractText=When the AST/ALT ratio was regarded as a categorical variable, AST/ALT quartiles 9-2.19) kept independent effects on the presence of LMM status. When it was regarded as a continuous variable, each unit of the AST/ALT ratio was significantly associated with a 49% (P < 0.01) augment of the prevalence of LMM. By multiple general linear regression analysis, the formula was constructed with an adjusted R2 of 0.72: SMI (kg/m2) = -0.14 AST/ALT ratio + 1.35 sex (male: 1; female: 0) + 0.72 overweight status (yes: 1; no: 0) - 0.14 age (≤65: 0; >65: 1) + 6.26.}, In general, the high AST/ALT ratio was an independent adverse indicator of the presence of LMM.
资助项目	Wenzhou Municipal Sci-Tech Bureau's Program [Y20220364]
出版者	ELSEVIER SCIENCE INC
ISSN	0899-9007
EISSN	1873-1244
卷号	117
DOI	10.1016/j.nut.2023.112214
页数	7
WOS类目	Nutrition & Dietetics
WOS研究方向	Nutrition & Dietetics
WOS记录号	WOS:001106959900001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37837772
SCOPUSEID	2-s2.0-85173234333
通讯作者地址	[Chen, Mengjun]Department of Gastroenterology,the First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Nutrition and Dietetics
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183406
专题	第一临床医学院（信息与工程学院）、附属第一医院_麻醉科附属第一医院附属第一医院_麻醉科
通讯作者	Chen, Mengjun
作者单位	1.Department of Anesthesiology,the First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Gastroenterology,Shangyu People's Hospital,Zhejiang,Shaoxing,China; 3.Department of Gastroenterology,the First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_麻醉科; 附属第一医院_麻醉科
通讯作者单位	附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_麻醉科; 附属第一医院_麻醉科
推荐引用方式 GB/T 7714	Hong, Huisuo,Jiang, Kewei,Ye, Huajun,et al. The aspartate aminotransferase to alanine aminotransferase ratio: A novel indicator for skeletal muscle mass in Chinese community adults[J]. Nutrition (Burbank, Los Angeles County, Calif.),2024,117.
APA	Hong, Huisuo, Jiang, Kewei, Ye, Huajun, Xue, Haibo, & Chen, Mengjun. (2024). The aspartate aminotransferase to alanine aminotransferase ratio: A novel indicator for skeletal muscle mass in Chinese community adults. Nutrition (Burbank, Los Angeles County, Calif.), 117.
MLA	Hong, Huisuo,et al."The aspartate aminotransferase to alanine aminotransferase ratio: A novel indicator for skeletal muscle mass in Chinese community adults".Nutrition (Burbank, Los Angeles County, Calif.) 117(2024).