miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R

doi:10.1155/2023/6882851

科研成果详情

题名	miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R
作者	Huang, Zhengwei 1,2; Luo, Yacan 1; Chen, Congcong 2; Zhou, Chaoyang 3; Su, Zhengkang 2; Cai, Chang1; Li, Xi2; Wu, Wenzhi1
发表日期	2023-09-19
发表期刊	CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	BINDING PROTEIN HUR ; IDENTIFICATION ; PROGRESSION ; EXPRESSION ; XENOGRAFT ; TARGET
摘要	Human antigen R (HuR), also known as ELAVL1, is a widely expressed RNA-binding protein (RBP) that has a significant impact on the development and advancement of tumors. Our previous study found that 5-fuorouracil (5-FU) may impede the proliferation and increase apoptosis in gastric cancer cells by reducing the nucleocytoplasmic shuttling of HuR. However, how posttranscriptional regulation infuences HuR functions in gastric cancer remains to be elucidated. Here, we demonstrated that miR-325-3p has the potential to regulate the expression level of HuR by directly binding to its 3 ' UTR, which in turn led to a significant reduction in proliferation and an increase in apoptosis in gastric cancer cells. In addition, xenograft experiment showed that knockdown of HuR or overexpression of miR-325-3p group exhibited smaller tumor sizes after transplant of gastric cancer cells into zebrafish larvae. Thus, our findings offer new insights into the pathogenesis of gastric cancer and may potentially assist in identifying novel targets for drug therapy.
资助项目	We appreciate Anqi Guo, Fengqing Qin, Shengnan Xu, and Miaomiao Zheng for providing basic support in the experiment and thank Ya Zhu for revising the text and format of the article. This work was supported by the Natural Science Foundation of Zhejiang Prov [LY20C120001]; Natural Science Foundation of Zhejiang Province, China
出版者	HINDAWI LTD
ISSN	2291-2789
EISSN	2291-2797
卷号	2023
DOI	10.1155/2023/6882851
页数	10
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:001076313200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37766807
SCOPUSEID	2-s2.0-85172801746
通讯作者地址	[Wu, Wenzhi]Department of Gastroenterology and Hepatology,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Li, Xi]Affiliated Kangning Hospital of Wenzhou Medical University,Zhejiang Provincial Clinical Research Center for Mental Disorder,Wenzhou,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183186
专题	附属第一医院其他_附属康宁医院（温州市康宁医院）
通讯作者	Li, Xi; Wu, Wenzhi
作者单位	1.Department of Gastroenterology and Hepatology,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Affiliated Kangning Hospital of Wenzhou Medical University,Zhejiang Provincial Clinical Research Center for Mental Disorder,Wenzhou,China; 3.Intensive Care Unit,People's Hospital of Yuhuan,Yuhuan,China
第一作者单位	附属第一医院; 附属康宁医院（温州市康宁医院）
通讯作者单位	附属第一医院; 附属康宁医院（温州市康宁医院）
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Huang, Zhengwei,Luo, Yacan,Chen, Congcong,et al. miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R[J]. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2023,2023.
APA	Huang, Zhengwei., Luo, Yacan., Chen, Congcong., Zhou, Chaoyang., Su, Zhengkang., ... & Wu, Wenzhi. (2023). miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2023.
MLA	Huang, Zhengwei,et al."miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R".CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2023(2023).