Lipidomics Profiling Reveals Serum Phospholipids Associated with Albuminuria in Early Type 2 Diabetic Kidney Disease

doi:10.1021/acsomega.3c05504

科研成果详情

题名	Lipidomics Profiling Reveals Serum Phospholipids Associated with Albuminuria in Early Type 2 Diabetic Kidney Disease
作者	Ye, Shu 1; Hu, Ye-Peng 1; Zhou, Qiao 1; Zhang, Hang3; Xia, Zhe-Zheng4; Zhao, Shu-Zhen4; Wang, Zhe 1; Wang, Sheng-Yao 1; Wang, Xin-Yi 1; Zhang, Yi-Kai 1; Chen, Zhi-Da 2; Mao, Guang-Yun4; Zheng, Chao1,3
发表日期	2023-09-22
发表期刊	ACS OMEGA 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	PHOSPHATIDYLSERINE ; INDIVIDUALS ; NEPHROPATHY ; DIAGNOSIS
摘要	Early screening and administration of DKD are beneficial for renal outcomes of type 2 diabetic patients. However, the current early diagnosis using the albuminuria/creatine ratio (ACR) contains limitations. This study aimed to compare serum lipidome variation between type 2 diabetes and early DKD patients with increased albuminuria through an untargeted lipidomics method to explore the potential lipid biomarkers for DKD identification. 92 type 2 diabetic patients were enrolled and divided into two groups: DM group (ACR < 3 mg/mmol, n = 49) and early DKD group (3 mg/mmol = ACR < 30 mg/mmol, n = 43). Fasting serum was analyzed through an ultraperformance liquid mass spectrometry tandem chromatography system (LC-MS). Orthogonal partial least-squares discriminant analysis (OPLS-DA) and univariate and multivariate analysis were performed to filter differentially depressed lipids. Receiver operating characteristic (ROC) curves were used to estimate the diagnostic capability of potential lipid biomarkers. We found that serum phospholipids including phosphatidylserine (PS), sphingomyelin (SM), and phosphatidylcholine (PC) were significantly upregulated in the DKD group and were highly correlated with the ACR. In addition, a panel of two phospholipids including PS(27:0)-H and PS(30:2e)-H showed good performance to help clinical lipids in early DKD identification, which increased the area under the curve (AUC) from 0.568 to 0.954. The study exhibited the serum lipidome variation in early DKD patients, and the increased phospholipids might participate in the development of albuminuria. The panel of PS(27:0)-H and PS(30:2e)-H could be a potential biomarker for DKD diagnosis.
资助项目	Zhejiang University; Wenzhou Medical University
出版者	AMER CHEMICAL SOC
ISSN	2470-1343
卷号	8 期号:39 页码:36543-36552
DOI	10.1021/acsomega.3c05504
页数	10
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:001071353900001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-09
URL	查看原文
PubMed ID	37810655
SCOPUSEID	2-s2.0-85174954732
通讯作者地址	[Zheng, Chao]Department of Endocrinology,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310027,China
Scopus学科分类	Chemistry (all);Chemical Engineering (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183179
专题	第二临床医学院、附属第二医院、育英儿童医院公共卫生学院附属第二医院眼视光学院（生物医学工程学院）、附属眼视光医院_临床与流行病学研究中心
通讯作者	Zheng, Chao
作者单位	1.Department of Endocrinology,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310027,China; 2.Department of Nephrology,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310027,China; 3.Diabetes Center and Department of Endocrinology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China; 4.Center on Evidence-Based Medicine & Clinical Epidemiological Research,School of Public Health,Wenzhou Medical University,Wenzhou,325035,China
推荐引用方式 GB/T 7714	Ye, Shu,Hu, Ye-Peng,Zhou, Qiao,et al. Lipidomics Profiling Reveals Serum Phospholipids Associated with Albuminuria in Early Type 2 Diabetic Kidney Disease[J]. ACS OMEGA,2023,8(39):36543-36552.
APA	Ye, Shu., Hu, Ye-Peng., Zhou, Qiao., Zhang, Hang., Xia, Zhe-Zheng., ... & Zheng, Chao. (2023). Lipidomics Profiling Reveals Serum Phospholipids Associated with Albuminuria in Early Type 2 Diabetic Kidney Disease. ACS OMEGA, 8(39), 36543-36552.
MLA	Ye, Shu,et al."Lipidomics Profiling Reveals Serum Phospholipids Associated with Albuminuria in Early Type 2 Diabetic Kidney Disease".ACS OMEGA 8.39(2023):36543-36552.