全身免疫炎症指数对急性呼吸窘迫综合征预后的评估

doi:10.3760/cma.j.issn.1671-0282.2023.08.009

科研成果详情

题名	全身免疫炎症指数对急性呼吸窘迫综合征预后的评估
其他题名	Prognostic significance of systemic immune-inflammatory index in patients with acute respiratory distress syndrome
作者	王仁女 1; 汪洁 2; 毛宝杰 3; 万曙
发表日期	2023-08-10
发表期刊	中华急诊医学杂志影响因子和分区
语种	中文
原始文献类型	Periodical
关键词	全身免疫炎症指数急性呼吸窘迫综合征病死率危险因素倾向评分匹配分析炎症重症监护病房 MIMIC Ⅲ
其他关键词	Systemic immune-inflammatory index ; Acute respiratory distress syndrome ; mortality ; Risk factors ; Propensity score matching ; Inflammation ; Intensive care unit ; MIMIC Ⅲ
摘要	目的评估全身免疫炎症指数水平(systemic immune-inflammatory index,SⅡ)预测急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)预后的关系.方法选取重症监护医学信息数据库Ⅲ的ARDS患者为研究对象.患者随访一年.主要终点是30 d病死率,次要终点90 d病死率和一年病死率.Cox比例风险回归评估SⅡ是ARDS患者的独立危险因素,倾向性得分匹配,控制混杂因素.结果本研究共纳入723名ARDS患者,较于SⅡ＜3655,SⅡ≥3655,患者年龄更加高,SpO2更低,简化急性生理学评分Ⅱ,序贯器官衰竭评分,30 d,90 d和一年病死率更加高.Cox比例风险回归分析显示,SⅡ高水平是30 d、90 d、一年ARDS预后的独立危险因素[(HR=1.68,95％CI:1.19～2.36,P=0.0028),(HR=1.46,95％CI:1.07～1.99,P=0.0170),(HR=1.34,95％CI:1.01～1.77,P=0.0425)].倾向评分匹配分析进一步证实了 SⅡ与ARDS患者预后的关系.结论 SⅡ作为一个简单且易重复的指标,是ARDS患者独立危险因素.
其他摘要	Objective:To evaluate the relationship between systemic immune-inflammatory index (SII) and prognosis of acute respiratory distress syndrome (ARDS).Methods:ARDS patients from the I Medical Information Mart for Intensive CareⅢ were selected as the study objects. Patients were followed up for one year. The primary endpoint was the 30-day mortality rate, and secondary endpoints were the 90-day and one-year mortality rates. Cox proportional hazard regression analysis was used to assess SII as an independent risk factor for ARDS patients, with propensity score matching to control for confounding factors.Results:A total of 723 ARDS patients were included in this study. Patients with SII≥ 3655 had older age, lower SpO 2 levels, and higher simplified acute physiology scoreⅡ (SAPSⅡ) and sequential organ failure assessment (SOFA) scores compared to those with SII <3655. Additionally, the 30-day, 90-day, and one-year mortality rates were higher in patients with SII ≥3655. Cox proportional hazard regression analysis showed that high SII level was an independent risk factor for the prognosis of ARDS at 30 days ( HR=1.68, 95% CI: 1.19-2.36, P=0.0028), 90 days ( HR=1.46, 95% CI: 1.07-1.99, P=0.0170), and one year ( HR=1.34, 95% CI: 1.01-1.77, P=0.0425). Propensity score matching analysis further confirmed the relationship between SII and the prognosis of ARDS patients. Conclusions:SII, as a simple and easily measurable index, is an independent risk factor for the prognosis of ARDS patients.
ISSN	1671-0282
卷号	32 期号:8 页码:1061-1065
DOI	10.3760/cma.j.issn.1671-0282.2023.08.009
页数	5
收录类别	万方 ; SCOPUS ; 维普 ; ISTIC ; 北大核心 ; ISTIC ; CSCD
URL	查看原文
SCOPUSEID	2-s2.0-85175865634
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/183095
专题	附属第二医院_内分泌科
作者单位	1.浙江中医药大学,杭州 310053; 2.浙江医院,杭州 310013; 3.温州医科大学附属第二医院内分泌科,温州 325027
推荐引用方式 GB/T 7714	王仁女,汪洁,毛宝杰,等. 全身免疫炎症指数对急性呼吸窘迫综合征预后的评估[J]. 中华急诊医学杂志,2023,32(8):1061-1065.
APA	王仁女, 汪洁, 毛宝杰, & 万曙. (2023). 全身免疫炎症指数对急性呼吸窘迫综合征预后的评估. 中华急诊医学杂志, 32(8), 1061-1065.
MLA	王仁女,et al."全身免疫炎症指数对急性呼吸窘迫综合征预后的评估".中华急诊医学杂志 32.8(2023):1061-1065.