Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice

doi:10.1016/j.cub.2023.08.070

科研成果详情

题名	Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice
作者	Song, Da 1; Wang, Chunjian 1; Jin, Yue 1; Deng, Yujun 1; Yan, Yan 1; Wang, Deheng 2; Zhu, Zilu 2; Ke, Zunji 2; Wang, Zhe 3; Wu, Yili4; Ni, Junjun 1; Qing, Hong 1,5; Quan, Zhenzhen 1
发表日期	2023-10-23
发表期刊	Current biology : CB 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	anterior cingulate cortex harm avoidance mediodorsal thalamus neural activity neural circuit modulation social behavior
其他关键词	PAIN ; EMPATHY ; ALTRUISM ; CIRCUIT
摘要	Many species living in groups can perform prosocial behaviors via voluntarily helping others with or without benefits for themselves. To provide a better understanding of the neural basis of such prosocial behaviors, we adapted a preference lever-switching task in which mice can prevent harm to others by switching from using a lever that causes shocks to a conspecific one that does not. We found the harm avoidance behavior was mediated by self-experience and visual and social contact but not by gender or familiarity. By combining single-unit recordings and analysis of neural trajectory decoding, we demonstrated the dynamics of anterior cingulate cortex (ACC) neural activity changes synchronously with the harm avoidance performance of mice. In addition, ACC neurons projected to the mediodorsal thalamus (MDL) to modulate the harm avoidance behavior. Optogenetic activation of the ACC-MDL circuit during non-preferred lever pressing (nPLP) and inhibition of this circuit during preferred lever pressing (PLP) both resulted in the loss of harm avoidance ability. This study revealed the ACC-MDL circuit modulates prosocial behavior to avoid harm to conspecifics and may shed light on the treatment of neuropsychiatric disorders with dysfunction of prosocial behavior.
资助项目	National Natural Science Foundation of China[32070954,92049102];Ministry of Science and Technology of China[2022ZD02068000];Beijing Municipal Natural Science Foundation[7222113];Beijing Nova Program[20220484083];
出版者	CELL PRESS
ISSN	0960-9822
EISSN	1879-0445
卷号	33 期号:20 页码:4330-4342.e5
DOI	10.1016/j.cub.2023.08.070
页数	19
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS记录号	WOS:001095009900001
收录类别	PUBMED ; SCOPUS ; SCIE
在线发表日期	2023-10
URL	查看原文
PubMed ID	37734375
SCOPUSEID	2-s2.0-85173153321
自科自定义期刊分类	T3(B)类
通讯作者地址	[Qing, Hong]Key Laboratory of Molecular Medicine and Biotherapy,School of Life Science,Beijing Institute of Technology,Beijing,100081,China ; [Quan, Zhenzhen]Key Laboratory of Molecular Medicine and Biotherapy,School of Life Science,Beijing Institute of Technology,Beijing,100081,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all);Agricultural and Biological Sciences (all)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182978
专题	卓越中心_老年研究院精神医学学院
通讯作者	Qing, Hong; Quan, Zhenzhen
作者单位	1.Key Laboratory of Molecular Medicine and Biotherapy,School of Life Science,Beijing Institute of Technology,Beijing,100081,China; 2.School of Basic Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China; 3.Advanced Innovation Center for Human Brain Protection and The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing,100069,China; 4.Key Laboratory of Alzheimer's Disease of Zhejiang Province,School of Mental Health,Institute of Aging,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 5.Department of Biology,Shenzhen MSU-BIT University,Shenzhen,518172,China
推荐引用方式 GB/T 7714	Song, Da,Wang, Chunjian,Jin, Yue,et al. Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice[J]. Current biology : CB,2023,33(20):4330-4342.e5.
APA	Song, Da., Wang, Chunjian., Jin, Yue., Deng, Yujun., Yan, Yan., ... & Quan, Zhenzhen. (2023). Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice. Current biology : CB, 33(20), 4330-4342.e5.
MLA	Song, Da,et al."Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice".Current biology : CB 33.20(2023):4330-4342.e5.