Antifouling and Injectable Granular Hydrogel for the Prevention of Postoperative Intrauterine Adhesion

doi:10.1021/acsami.3c07846

科研成果详情

题名	Antifouling and Injectable Granular Hydrogel for the Prevention of Postoperative Intrauterine Adhesion
作者	Xia, Weiting 1,2; Wang, Qilin 4; Liu, Ming 1,2; Lu, Shaoping 4; Yu, Hui 4; Yin, Haiyan 4; You, Min 4; Chen, Qiang 4; Wang, Bujun 3; Lin, Feng 1,2
发表日期	2023-09-18
发表期刊	ACS applied materials & interfaces 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	antifouling granular hydrogel injectable intrauterine adhesion restore reproductive function
其他关键词	PERFORMANCE
摘要	Postoperative intrauterine adhesion (IUA), caused by endometrial basal layer injury, is one of the main causes of female infertility. The excessive deposition of fibrin as well as fibroblast is considered the root cause of IUA. However, few clinical strategies are effective in preventing extracellular matrix (ECM) deposition at endometrial wounds that include protein and cell deposits. Herein, the injectable granular poly(N-(2-hydroxyethyl) acrylamide) (PHEAA) hydrogel (granular PHEAA gel), which presents excellent antifouling properties and remarkably prevents protein and cell adhesions, is used to prevent postoperative IUA. The granular PHEAA gel with a jammed network structure exhibits outstanding injectability and superior stability. Compared with the IUA group, the granular PHEAA gel can promote regeneration of the endometrium while reducing the area of endometrial fibrosis. Immunohistochemical staining experiments indicate that the granular PHEAA gel can improve the proliferation of the endometrium, promote vascularization, and enhance anti-inflammatory effect in IUA rats. And the granular PHEAA gel can effectively slow down the fibrosis of uterine tissue. Importantly, the number of embryos is significantly increased after injecting granular PHEAA gel, inferring that there is an obvious reproductive function recovery of injured endometrium
资助项目	Excellent Youth Fund Project ofHenan Natural Science Foundation [202300410166]; National Natural Science Foundation of China [22202051]; Major Project of WIUCAS [WIUCASQD2021004, WIUCASQD2021035]; Project of Wenzhou Key Lab [2021HZSY0069]; Project of Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province [2022E10022]; Science Foundation of Oujiang Laboratory [OJQDSP2022018]
出版者	AMER CHEMICAL SOC
ISSN	1944-8244
EISSN	1944-8252
卷号	15 期号:38 页码:44676-44688
DOI	10.1021/acsami.3c07846
页数	13
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001068610900001
收录类别	PUBMED ; SCIE ; EI ; SCOPUS
在线发表日期	2023-09
EI入藏号	20234414984574
EI主题词	Proteins
EI分类号	461.9 Biology ; 801.3 Colloid Chemistry ; 802.3 Chemical Operations ; 804 Chemical Products Generally ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	37721504
SCOPUSEID	2-s2.0-85172712869
通讯作者地址	[Lin, Feng]Department of Gynecology,Wenzhou,325000,China ; [Wang, Bujun]Department of Obstetrics,Pingyang People's Hospital of Wenzhou Medical University,Wenzhou,325499,China ; [Chen, Qiang]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,352001,China
Scopus学科分类	Materials Science (all)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182933
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Chen, Qiang; Wang, Bujun; Lin, Feng
作者单位	1.Department of Gynecology,Wenzhou,325000,China; 2.Key Lab. of Clin. Lab. Diagn. and Translational Res. of Zhejiang Prov. the First Affil. Hosp. of Wenzhou Med. Univ.,Wenzhou,325000,China; 3.Department of Obstetrics,Pingyang People's Hospital of Wenzhou Medical University,Wenzhou,325499,China; 4.Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,352001,China
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
推荐引用方式 GB/T 7714	Xia, Weiting,Wang, Qilin,Liu, Ming,et al. Antifouling and Injectable Granular Hydrogel for the Prevention of Postoperative Intrauterine Adhesion[J]. ACS applied materials & interfaces,2023,15(38):44676-44688.
APA	Xia, Weiting., Wang, Qilin., Liu, Ming., Lu, Shaoping., Yu, Hui., ... & Lin, Feng. (2023). Antifouling and Injectable Granular Hydrogel for the Prevention of Postoperative Intrauterine Adhesion. ACS applied materials & interfaces, 15(38), 44676-44688.
MLA	Xia, Weiting,et al."Antifouling and Injectable Granular Hydrogel for the Prevention of Postoperative Intrauterine Adhesion".ACS applied materials & interfaces 15.38(2023):44676-44688.