Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing

doi:10.1039/c9tb02331c

科研成果详情

题名	Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing
作者	Xuan, Xuan1,2; Zhou, Yajiao 2; Chen, Anqi 2; Zheng, Sen 2; An, Ying 2; He, Huacheng 3; Huang, Wen 2; Chen, Yanxin 3; Yang, Yao 3; Li, Shengyu 3; Xuan, Tengxiao 2; Xiao, Jian2; Li, Xiaokun1,2,3; Wu, Jiang1,2
发表日期	2020-02-21
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Bioactivity Cell culture Controlled drug delivery Hydrogels Tissue regeneration Attractive solutions Bacterial inhibition Basic fibroblast growth factor Immobilization matrices Inflammatory response Neo-vascularization Supramolecular hydrogels Therapeutic potentials
其他关键词	CELL-PROLIFERATION ; METAL-IONS ; SULFADIAZINE ; REGENERATION ; BACTERIA
摘要	Topical wound dressings with various silver compositions that exhibit effective bacterial inhibition properties are often used to treat infected wounds. However, a silver dressing with no bioactive functionality will typically delay subsequent wound repair processes. Therefore, development of a simple wound dressing containing silver and loaded with a bioactive drug is a very attractive solution. Herein, we developed a silver crosslinked injectable chitosan-silver hydrogel as a silver immobilization matrix, loaded with basic fibroblast growth factor (bFGF) as its cargo (namely, bFGF@CS-Ag) for treatment of both acute and infected wounds. The in vivo results showed that bFGF@CS-Ag significantly enhanced infectious wound regeneration compared to that of acute wounds. Further investigation demonstrated that the improved wound repair by bFGF@CS-Ag was ascribed to the effectiveness of bacterial inhibition, the promotion of granulation formation, collagen deposition, neovascularization and re-epithelization, and to the reduction of the inflammatory response through promotion of M2 macrophage polarization. These results proved that the immobilization of silver in the hydrogel not only reduced the side effects of silver on the bioactivity of bFGF but also allowed elution of bFGF in a controlled release manner. Thus, this novel system has promising therapeutic potential for topical treatment of wounds.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LGF19H180008]; Zhejiang Qianjiang Talent project [QJD1803015]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701809, 81601615]; Wenzhou Municipal Science & Technology Bureau of China [Y20180149]
出版者	ROYAL SOC CHEMISTRY
出版地	CAMBRIDGE
ISSN	2050-750X
EISSN	2050-7518
卷号	8 期号:7 页码:1359-1370
DOI	10.1039/c9tb02331c
页数	37
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:000515708700022
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20201008256129
EI主题词	Silver
URL	查看原文
PubMed ID	31840731
SCOPUSEID	2-s2.0-85080108957
通讯作者地址	[He, Huacheng]Department of Dermatology,First Affiliated Hospital,Wenzhou Medical University,Zhejiang,China
Scopus学科分类	Chemistry (all);Biomedical Engineering;Materials Science (all)
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18291
专题	药学院（分析测试中心）附属第一医院研究生工作部（研究生院）
通讯作者	He, Huacheng
作者单位	1.Department of Dermatology,First Affiliated Hospital,Wenzhou Medical University Wenzhou,Zhejiang,China; 2.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou, Zhejiang,China
第一作者单位	附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xuan, Xuan,Zhou, Yajiao,Chen, Anqi,et al. Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(7):1359-1370.
APA	Xuan, Xuan., Zhou, Yajiao., Chen, Anqi., Zheng, Sen., An, Ying., ... & Wu, Jiang. (2020). Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing. JOURNAL OF MATERIALS CHEMISTRY B, 8(7), 1359-1370.
MLA	Xuan, Xuan,et al."Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing".JOURNAL OF MATERIALS CHEMISTRY B 8.7(2020):1359-1370.