Research Progress in Neonatal Alloimmune Thrombocytopenia: A Narrative Review

科研成果详情

题名	Research Progress in Neonatal Alloimmune Thrombocytopenia: A Narrative Review
作者	Zhou, Enmin 1; Wang, Kai 2; Gu, Yitao 3
发表日期	2023-09
发表期刊	ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE 影响因子和分区
语种	英语
原始文献类型	Review
其他关键词	INTRAVENOUS IGG ; FETAL
摘要	Background circle Neonatal alloimmune thrombocytopenia (NAIT) is an immune disorder characterized by maternal antibodies that destroy fetal platelets, leading to thrombocytopenia. The prevalence of NAIT is approximately 0.05% to 0.15%. Fetal and neonatal severe thrombocytopenia represents the most common form of the disease, primarily occurring in firstborn children. It poses a greater risk and harm to the fetus and newborn. Neonatal intracranial hemorrhage is a severe complication of NAIT, resulting in irreversible damage to cranial nerves and potential neonatal death. Objective circle This study aims to assess the current advancements in the pathogenesis, clinical characteristics, laboratory evaluation, and therapeutic interventions for neonatal alloimmune thrombocytopenia. Methods circle This narrative review explores neonatal alloimmune thrombocytopenia through a thorough literature review. The study encompasses the pathogenesis, clinical features, laboratory examination, and treatment options associated with this condition. Results circle The results of this study highlight that despite the extremely low incidence of NAIT, it carries a high risk. Currently, there is no timely and effective prevention method available. However, using HPA-1a as a screening item for prenatal prevention shows the potential to reduce the mortality rate of NAIT fetuses. Further research is required to evaluate its accuracy and specificity. Conclusions circle The findings of this review emphasize the need for further research to develop effective prevention methods. The use of HPA-1a as a screening tool holds promise but requires additional investigation. Enhancing clinical understanding of NAIT will contribute to improved management and outcomes for affected infants.
出版者	InnoVision Professional Media
ISSN	1078-6791
卷号	29 期号:6 页码:77-81
页数	5
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
WOS记录号	WOS:001050004000011
收录类别	SCIE
PubMed ID	3731889
通讯作者地址	[Zhou, Enmin]Zhejiang Univ, Childrens Hosp, Sch Med, Dept Hematol Oncol,Natl Clin Res Ctr Child Hlth, Hangzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182800
专题	附属第一医院_儿科
通讯作者	Zhou, Enmin
作者单位	1.Zhejiang Univ, Childrens Hosp, Sch Med, Dept Hematol Oncol,Natl Clin Res Ctr Child Hlth, Hangzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pediat, Wenzhou, Zhejiang, Peoples R China; 3.Shaoxing Shangyu Maternal & Child Hlth Hosp, Dept Pediat, Shaoxing, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Enmin,Wang, Kai,Gu, Yitao. Research Progress in Neonatal Alloimmune Thrombocytopenia: A Narrative Review[J]. ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE,2023,29(6):77-81.
APA	Zhou, Enmin, Wang, Kai, & Gu, Yitao. (2023). Research Progress in Neonatal Alloimmune Thrombocytopenia: A Narrative Review. ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE, 29(6), 77-81.
MLA	Zhou, Enmin,et al."Research Progress in Neonatal Alloimmune Thrombocytopenia: A Narrative Review".ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE 29.6(2023):77-81.