Minimal effect of sleep on the risk of age-related macular degeneration: a Mendelian randomization study

doi:10.3389/fnagi.2023.1159711

科研成果详情

题名	Minimal effect of sleep on the risk of age-related macular degeneration: a Mendelian randomization study
作者	Zhu, Rong-Cheng 1; Li, Fen-Fen 2,3; Wu, Yi-Qing4; Yi, Quan-Yong 5; Huang, Xiu-Feng1
发表日期	2023-08-21
发表期刊	Frontiers in aging neuroscience 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Mendelian randomization age-related macular degeneration causal inference genetic instrument sleep duration
其他关键词	CORONARY-HEART-DISEASE ; DURATION ; INSTRUMENTS ; MELATONIN
摘要	Observational studies have shown that sleep pattern is associated with age-related macular degeneration (AMD), but whether sleep pattern is a causal factor for AMD remains unclear. This study aims to use Mendelian randomization (MR) analysis to investigate the potential causal relationship between sleep traits and AMD., This is a two-sample MR study. The single-nucleotide polymorphisms associated with AMD and early AMD were selected as the outcome from two different genome-wide association studies (GWAS): the early AMD GWAS with 14,034 cases and 91,214 controls, and AMD GWAS with 3,553 cases and 147,089 controls. The datasets of sleep duration, daytime dozing, and sleeplessness were used as exposure, which comprised nearly 0.46 million participants. Inverse-variance weighted method was used as the main result, and comprehensive sensitivity analyses were conducted to estimate the robustness of identified associations and the impact of potential horizontal pleiotropy., {AbstractText=Through MR analysis, we found that sleep duration was significantly associated with AMD (OR = 0.983, 95% CI = 0.970-0.996, P-value = 0.01). We also found suggestive evidence for the association of genetically predicted sleep duration with early AMD, which showed a consistent direction of effect with a marginal significance (OR = 0.724, 95% CI = 0.503-1.041, P-value = 0.08). Sensitivity analyses further supported the robustness of the causal relationship between sleep duration and AMD. However, we were unable to determine the relationship between daytime dozing or sleeplessness and AMD (including early AMD) (P-value > 0.05).}, Sleep duration affects the causal risk for AMD; that is, longer sleep duration reduces the risk of AMD, while shorter sleep duration increases the risk of AMD. Although the influence is minimal, keeping adequate sleep duration is recommended, especially for patients with intermediate or advanced AMD.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LGF22H120013, LY22H120008]; Zhejiang Provincial Clinical Research Center for Pediatric Disease [2022E50003]; National Natural Science Foundation of China [82070981, 82201229]
出版者	FRONTIERS MEDIA SA
ISSN	1663-4365
卷号	15
DOI	10.3389/fnagi.2023.1159711
页数	8
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS记录号	WOS:001060432900001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37671084
SCOPUSEID	2-s2.0-85169699433
通讯作者地址	[Huang, Xiu-Feng]Zhejiang Provincial Clinical Research Center for Pediatric Disease,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Li, Fen-Fen]National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,China ; [Yi, Quan-Yong]The Affiliated Ningbo Eye Hospital of Wenzhou Medical University,Zhejiang,Ningbo,China
Scopus学科分类	Aging;Cognitive Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182770
专题	第二临床医学院，附属第二医院、育英儿童医院眼视光学院（生物医学工程学院）、附属眼视光医院其他_附属宁波市眼科医院
通讯作者	Li, Fen-Fen; Yi, Quan-Yong; Huang, Xiu-Feng
作者单位	1.Zhejiang Provincial Clinical Research Center for Pediatric Disease,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,China; 3.State Key Laboratory of Ophthalmology,Optometry and Visual Science,Eye Hospital,Wenzhou Medical University,Wenzhou,China; 4.Department of Pediatrics,The Second School of Medicine,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 5.The Affiliated Ningbo Eye Hospital of Wenzhou Medical University,Zhejiang,Ningbo,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 眼视光学院（生物医学工程学院）、附属眼视光医院; 其他_附属宁波市眼科医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Zhu, Rong-Cheng,Li, Fen-Fen,Wu, Yi-Qing,et al. Minimal effect of sleep on the risk of age-related macular degeneration: a Mendelian randomization study[J]. Frontiers in aging neuroscience,2023,15.
APA	Zhu, Rong-Cheng, Li, Fen-Fen, Wu, Yi-Qing, Yi, Quan-Yong, & Huang, Xiu-Feng. (2023). Minimal effect of sleep on the risk of age-related macular degeneration: a Mendelian randomization study. Frontiers in aging neuroscience, 15.
MLA	Zhu, Rong-Cheng,et al."Minimal effect of sleep on the risk of age-related macular degeneration: a Mendelian randomization study".Frontiers in aging neuroscience 15(2023).