Targeting NLRP3 inflammasome for neurodegenerative disorders

doi:10.1038/s41380-023-02239-0

科研成果详情

题名	Targeting NLRP3 inflammasome for neurodegenerative disorders
作者	Yao, Jing 1; Wang, Zhe 1; Song, Weihong1,2; Zhang, Yun 1
发表日期	2023-09-05
发表期刊	Molecular psychiatry 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
其他关键词	MILD COGNITIVE IMPAIRMENT ; TRAUMATIC BRAIN-INJURY ; ALZHEIMERS-DISEASE ; MOUSE MODEL ; PARKINSONS-DISEASE ; NALP3 INFLAMMASOME ; AMYLOID-BETA ; SYNAPTIC PLASTICITY ; CEREBROSPINAL-FLUID ; GASDERMIN D
摘要	Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing proteins (NLRs) belong to the pattern recognition receptors (PRRs) family that sense stress signals, which play an important role in inflammation. As a member of NLRs, the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) is predominantly expressed in microglia, the principal innate immune cells in the central nervous system (CNS). Microglia release proinflammatory cytokines to cause pyroptosis through activating NLRP3 inflammasome. The active NLRP3 inflammasome is involved in a variety of neurodegenerative diseases (NDs). Recent studies also indicate the key role of neuronal NLRP3 in the pathogenesis of neurological disorders. In this article, we reviewed the mechanisms of NLRP3 expression and activation and discussed the role of active NLRP3 inflammasome in the pathogenesis of NDs, particularly focusing on AD. The studies suggest that targeting NLRP3 inflammasome could be a novel approach for the disease modification.
资助项目	National Natural Science Foundation of China (National Science Foundation of China)[82230043];National Natural Science Foundation of China (National Science Foundation of China)[82201576]
出版者	SPRINGERNATURE
ISSN	1359-4184
EISSN	1476-5578
卷号	28 期号:11 页码:4512-4527
DOI	10.1038/s41380-023-02239-0
页数	16
WOS类目	Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:001058981500001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-09
URL	查看原文
PubMed ID	37670126
SCOPUSEID	2-s2.0-85169825132
自科自定义期刊分类	T3(A)类
通讯作者地址	[Song, Weihong]The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing,100053,China ; [Zhang, Yun]The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing,100053,China
Scopus学科分类	Molecular Biology;Cellular and Molecular Neuroscience;Psychiatry and Mental Health
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182767
专题	其他_附属康宁医院（温州市康宁医院）
通讯作者	Song, Weihong; Zhang, Yun
作者单位	1.The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing,100053,China; 2.Institute of Aging,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,Zhejiang Clinical Research Center for Mental Disorders,School of Mental Health and The Affiliated Kangning Hospital,Wenzhou Medical University,Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Zhejiang,Wenzhou,325000,China
推荐引用方式 GB/T 7714	Yao, Jing,Wang, Zhe,Song, Weihong,et al. Targeting NLRP3 inflammasome for neurodegenerative disorders[J]. Molecular psychiatry,2023,28(11):4512-4527.
APA	Yao, Jing, Wang, Zhe, Song, Weihong, & Zhang, Yun. (2023). Targeting NLRP3 inflammasome for neurodegenerative disorders. Molecular psychiatry, 28(11), 4512-4527.
MLA	Yao, Jing,et al."Targeting NLRP3 inflammasome for neurodegenerative disorders".Molecular psychiatry 28.11(2023):4512-4527.