Novel Curcumin Analogue L6H4 in Treating Liver Fibrosis and Type 2 Diabetes

doi:10.2147/DMSO.S425038

科研成果详情

题名	Novel Curcumin Analogue L6H4 in Treating Liver Fibrosis and Type 2 Diabetes
作者	Ma, Jun1; Vaishnani, Deep K.2; Mansi 2; Zeng, Jing 3; Xie, Zhenwen 3; Jin, Xuanchen 3; Zhang, Haixia3; Wut Yi Hla, Khaing 2; Ying, Furong4
发表日期	2023
发表期刊	Diabetes, metabolic syndrome and obesity : targets and therapy 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	L6H4 MMP–2 TGF-β1 TIMP–2 curcumin analogue type 2 diabetic rats
摘要	The objective of this study was to evaluate the therapeutic efficacy of the curcumin analogue L6H4 in attenuating liver fibrosis and alleviating insulin resistance in streptozotocin-induced diabetic rats., Male Sprague-Dawley rats were fed a high-fat diet to induce insulin resistance, followed by streptozotocin injection to induce diabetes. The rats were then treated with L6H4 for eight weeks. Body weight, metabolic parameters, liver function, and liver histopathology were evaluated. Immunohistochemistry was performed to assess the expression of TGF-β1, TIMP-2, and MMP-2 in liver tissues. Statistical analysis was conducted using one-way ANOVA and Spearman rank correlation test., L6H4 treatment effectively reversed the weight gain associated with a high-fat diet and improved metabolic parameters in diabetic rats. Liver function markers, such as ALT and AST, were reduced after L6H4 treatment. Histological analysis showed improved liver morphology and reduced fibrosis in L6H4-treated rats. Electron microscopy revealed improved ultrastructural features of hepatocytes. Immunohistochemistry demonstrated downregulation of TGF-β1 and TIMP-2 expression and restoration of MMP-2 expression in the liver tissue of L6H4-treated rats. Correlation analysis showed a significant positive correlation between TGF-β1 and TIMP-2 expression., The findings suggest that L6H4 has therapeutic potential in attenuating liver fibrosis and alleviating insulin resistance in streptozotocin-induced diabetic rats. The hepatoprotective effect of L6H4 may be attributed to its anti-inflammatory properties and its ability to target molecules involved in fibrosis. Further research is warranted to explore the potential of L6H4 as a treatment option for nonalcoholic fatty liver disease and type 2 diabetes.
资助项目	Wenzhou Science and Technology Plan Fund[Y20220745];Zhejiang Key Laboratory of Laboratory Diagnosis and Transformation Research[2022E10022];
ISSN	1178-7007
卷号	16 页码:2639-2650
DOI	10.2147/DMSO.S425038
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37667770
SCOPUSEID	2-s2.0-85170042882
通讯作者地址	[Ying, Furong]Department of Clinical Laboratory,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Internal Medicine;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182761
专题	附属第一医院温州医科大学国际教育学院
通讯作者	Ying, Furong
作者单位	1.Department of Pathology,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 2.School of International Studies,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 3.School of Clinical Medicine,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 4.Department of Clinical Laboratory,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Ma, Jun,Vaishnani, Deep K.,Mansi,et al. Novel Curcumin Analogue L6H4 in Treating Liver Fibrosis and Type 2 Diabetes[J]. Diabetes, metabolic syndrome and obesity : targets and therapy,2023,16:2639-2650.
APA	Ma, Jun., Vaishnani, Deep K.., Mansi., Zeng, Jing., Xie, Zhenwen., ... & Ying, Furong. (2023). Novel Curcumin Analogue L6H4 in Treating Liver Fibrosis and Type 2 Diabetes. Diabetes, metabolic syndrome and obesity : targets and therapy, 16, 2639-2650.
MLA	Ma, Jun,et al."Novel Curcumin Analogue L6H4 in Treating Liver Fibrosis and Type 2 Diabetes".Diabetes, metabolic syndrome and obesity : targets and therapy 16(2023):2639-2650.