Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis

doi:10.1016/j.envres.2023.116979

科研成果详情

题名	Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis
作者	Ghafouri, Elham 1; Bigdeli, Mandana 2; Khalafiyan, Anis 1; Amirkhani, Zohre 1; Ghanbari, Roham 3; Hasan, Anwarul 4,5; Khanahmad, Hossein 1; Boshtam, Maryam 6; Makvandi, Pooyan 7,8
发表日期	2023-12-01
发表期刊	Environmental research 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Acute respiratory distress syndrome COVID-19 Cancer Hypocalcemia Septic shock
其他关键词	CALCIUM-SENSING RECEPTOR ; OPERATED CA2+ ENTRY ; INOSITOL 1,4,5-TRISPHOSPHATE ; INTRACELLULAR CALCIUM ; ENDOPLASMIC-RETICULUM ; NLRP3 INFLAMMASOME ; CHANNEL BLOCKERS ; ACTIVATION ; APOPTOSIS ; PHOSPHATE
摘要	Calcium (Ca2+) homeostasis is crucial for maintaining physiological processes in the body, and disruptions in Ca2+ signaling can lead to various pathological conditions. Hypocalcemia, a common symptom in diseases such as acute respiratory distress syndrome (ARDS), cancer, septic shock, and COVID-19, can have both protective and detrimental effects. This article explores the multifaceted role of Ca2+ dysregulation in inflammation, fibrosis, impaired immune function, and accelerated senescence, contributing to disease severity. Targeting Ca2+ signaling pathways may provide opportunities to develop novel therapeutics for age-related diseases and combat viral infections. The role of Ca2+ in viral infections is complex, and evidence suggests that hypocalcemia may have a protective effect against certain viruses, while changes in Ca2+ homeostasis can influence susceptibility to viral infections. The effectiveness and safety of Ca2+ supplements in COVID-19 patients remain a subject of ongoing research and debate. Further investigations are needed to understand the intricate interplay between Ca2+ signaling and disease pathogenesis, informing better therapeutic interventions
出版者	Academic Press Inc.
ISSN	0013-9351
EISSN	1096-0953
卷号	238 期号:Pt 1
DOI	10.1016/j.envres.2023.116979
页数	15
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS记录号	WOS:001083157600001
收录类别	PUBMED ; EI ; SCIE ; SCOPUS
在线发表日期	2023-09
EI入藏号	20233814762071
EI主题词	COVID-19
EI分类号	461.6 Medicine and Pharmacology ; 461.7 Health Care ; 461.9 Biology
URL	查看原文
PubMed ID	37660871
SCOPUSEID	2-s2.0-85171566636
通讯作者地址	[Khanahmad, Hossein]Department of Genetics and Molecular Biology,School of Medicine,Isfahan University of Medical Sciences,Hezargarib Avenue,Isfahan,Iran ; [Boshtam, Maryam]Isfahan Cardiovascular Research Center,Cardiovascular Research Institute,Isfahan University of Medical Sciences,3rd Moshtagh Avenue,Isfahan,Iran ; [Makvandi, Pooyan]The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Zhejiang,Quzhou,324000,China
Scopus学科分类	Biochemistry;Environmental Science (all)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182741
专题	其他_温州医科大学附属衢州医院
通讯作者	Khanahmad, Hossein; Boshtam, Maryam; Makvandi, Pooyan
作者单位	1.Department of Genetics and Molecular Biology,School of Medicine,Isfahan University of Medical Sciences,Isfahan,Iran; 2.Department of Biology,Tehran University,Tehran,Iran; 3.School of Chemistry,College of Science,University of Tehran,Tehran,Iran; 4.Department of Mechanical and Industrial Engineering,Qatar University,Doha,2713,Qatar; 5.Biomedical Research Center,Qatar University,Doha,2713,Qatar; 6.Isfahan Cardiovascular Research Center,Cardiovascular Research Institute,Isfahan University of Medical Sciences,Isfahan,Iran; 7.The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Zhejiang,Quzhou,324000,China; 8.School of Engineering,Institute for Bioengineering,The University of Edinburgh,Edinburgh,EH9 3JL,United Kingdom
通讯作者单位	其他_温州医科大学附属衢州医院
推荐引用方式 GB/T 7714	Ghafouri, Elham,Bigdeli, Mandana,Khalafiyan, Anis,et al. Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis[J]. Environmental research,2023,238(Pt 1).
APA	Ghafouri, Elham., Bigdeli, Mandana., Khalafiyan, Anis., Amirkhani, Zohre., Ghanbari, Roham., ... & Makvandi, Pooyan. (2023). Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis. Environmental research, 238(Pt 1).
MLA	Ghafouri, Elham,et al."Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis".Environmental research 238.Pt 1(2023).