Valbenazine promotes body growth via growth hormone signaling during zebrafish embryonic development

doi:10.1016/j.taap.2023.116674

科研成果详情

题名	Valbenazine promotes body growth via growth hormone signaling during zebrafish embryonic development
作者	Su, Zhengkang 1; Dai, Ziru 2; Qin, Fengqing 2; Zhang, Hai 3; Zheng, Miaomiao 1; Zhu, Ya 1; Tong, Zhiqian4; Song, Weihong1,4; Li, Xi1
发表日期	2023-10-15
发表期刊	Toxicology and applied pharmacology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Dopamine VBZ VMAT2 Zebrafish larvae
其他关键词	TRANSPORTERS ; DOPAMINE
摘要	Vesicular monoamine transporter 2 (VMAT-2) functions by uptake of cytoplasmic monoamines into vesicles for storage. Valbenazine (VBZ) is a newly FDA-approved oral VMAT-2 inhibitor used for the treatment of movement disorders such as tardive dyskinesia (TD), and Tourette syndrome (TS). Clinical data shows that VBZ is a relatively safe drug with no cardiotoxicity or hepatotoxicity. However, the effect of VBZ on embryonic development remains unknown. Here, we use zebrafish larvae as an animal model to demonstrate that VBZ exposure causes premature hatching and increases body size and hyperactivity-like behaviors in zebrafish larvae. In addition, VBZ exposure leads to increased dopamine (DA) and Glutamate (Glu) levels. Moreover, an increased in the growth hormone (gh) and enriched PI3K/AKT signaling were found in VBZ-exposed zebrafish larvae, which may explain their accelerated development. In summary, VBZ exposure may be developmentally toxic in zebrafish larvae.
资助项目	Natural Science Foundation of Zhejiang Province [LY20C120001]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN	0041-008X
EISSN	1096-0333
卷号	477
DOI	10.1016/j.taap.2023.116674
页数	9
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:001150002000001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	37648088
SCOPUSEID	2-s2.0-85171130018
通讯作者地址	[Li, Xi]The Affiliated Kangning Hospital of Wenzhou Medical University,1 Shengjin Road, Lucheng,Wenzhou,325000,China ; [Song, Weihong]Institute of Aging,Key Laboratory of Alzheimer's Disease of Zhejiang Province,School of Mental Health and Kangning Hospital,The Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Toxicology;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182715
专题	其他_附属康宁医院（温州市康宁医院）卓越中心_老年研究院
通讯作者	Song, Weihong; Li, Xi
作者单位	1.The Affiliated Kangning Hospital of Wenzhou Medical University,Zhejiang Provincial Clinical Research Center for Mental Disorder,Zhejiang,Wenzhou,325000,China; 2.Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation,Beibu Gulf University,Guangxi,Qinzhou,535011,China; 3.College of Life and Environmental Science,Wenzhou University,Wenzhou,325035,China; 4.Institute of Aging,Key Laboratory of Alzheimer's Disease of Zhejiang Province,School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
第一作者单位	其他_附属康宁医院（温州市康宁医院）
通讯作者单位	其他_附属康宁医院（温州市康宁医院）; 卓越中心_老年研究院
第一作者的第一单位	其他_附属康宁医院（温州市康宁医院）
推荐引用方式 GB/T 7714	Su, Zhengkang,Dai, Ziru,Qin, Fengqing,et al. Valbenazine promotes body growth via growth hormone signaling during zebrafish embryonic development[J]. Toxicology and applied pharmacology,2023,477.
APA	Su, Zhengkang., Dai, Ziru., Qin, Fengqing., Zhang, Hai., Zheng, Miaomiao., ... & Li, Xi. (2023). Valbenazine promotes body growth via growth hormone signaling during zebrafish embryonic development. Toxicology and applied pharmacology, 477.
MLA	Su, Zhengkang,et al."Valbenazine promotes body growth via growth hormone signaling during zebrafish embryonic development".Toxicology and applied pharmacology 477(2023).