家族性渗出性玻璃体视网膜病变伴黄斑中心凹内层视网膜残留患眼黄斑区结构及血流改变

doi:10.3760/cma.j.cn511434-20230210-00058

科研成果详情

题名	家族性渗出性玻璃体视网膜病变伴黄斑中心凹内层视网膜残留患眼黄斑区结构及血流改变
其他题名	The macular structure and blood flow in familial exudative vitreoretinopathy with inner retinal layer persistence
作者	邵伊润 ; 毛剑波 3; 陈怡静2; 方宇燕 2; 沈丽君 3
发表日期	2023-07-25
发表期刊	中华眼底病杂志影响因子和分区
语种	中文
原始文献类型	Periodical
关键词	家族性渗出性玻璃体视网膜病变光相干断层扫描血管成像局部血流
其他关键词	Familial exudative vitreoretinopathy ; Optical coherence tomography angiography ; Regional blood flow
摘要	目的:对比观察早期家族性渗出性玻璃体视网膜病变（FEVR）伴或不伴黄斑中心凹内层视网膜（IRL）残留患眼的黄斑区微血管结构变化。方法:回顾性临床研究。2017年至2022年于温州医科大学附属眼视光医院杭州院区及浙江省人民医院眼科检查确诊的伴或不伴IRL残留的1期FEVR患者94例94只眼和年龄、性别匹配的健康志愿者45名45只眼（正常对照组）纳入研究。依据是否伴IRL残留将患者分为IRL组、非IRL组，分别为22例22只眼、72例72只眼。受检眼均行最佳矫正视力（BCVA）、光相干断层扫描血管成像（OCTA）检查。BCVA检查采用对数视力表进行，记录时转换为最小分辨角对数（logMAR）视力。采用OCTA仪对所有受检眼黄斑区3 mm×3 mm范围进行扫描，测量其总体、中心凹、旁中心凹的视网膜浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）血流密度以及黄斑中心凹无血管区（FAZ）面积、周长、非圆度指数（AI），FAZ范围300 μm宽度内的血流密度（FD-300）以及黄斑中心凹厚度（CMT）。三组间参数比较采用单因素方差分析。结果:与正常对照组比较，IRL组、非IRL组黄斑区3 mm×3 mm范围总体（ F=10.774、4.583）、旁中心凹（ F=10.433、3.912）SCP、DCP血流密度和CMT（ F=171.940）均降低，差异有统计学意义（ P<0.05）。三组FAZ面积（ F=4.315）、AI（ F=3.413）、FD-300（ F=13.592）比较，差异均有统计学意义（ P<0.05）。IRL组患眼BCVA最差。结论:FEVR患眼黄斑区血流密度下降，CMT显著厚于正常人群。中心凹IRL残留患眼FAZ面积小且不规则，具有更差的BCVA、更低的黄斑血流密度。
其他摘要	Objective:To compared the changes of macular microvascular architecture in early stage familial exudative vitreoretinopathy (FEVR) patients with inner retinal layer (IRL) persistence and without IRL persistence.Methods:A retrospective clinical study. From 2017 to 2022, 94 patients with stage 1 FEVR with or without IRL residue and 45 age- and sex-matched healthy volunteers with 45 eyes (normal control group) who were confirmed by ophthalmology examination in Hangzhou Hospital of Optometry Affiliated to Wenzhou Medical University and Zhejiang Provincial People's Hospital were included in the study. According to whether there was IRL residue, the patients were divided into IRL group and non-IRL group, with 22 patients (22 eyes) and 72 patients (72 eyes), respectively. Best corrected visual acuity (BCVA) and optical coherence tomography angiography (OCTA) were performed in all eyes. Superficial vessel density (SCP) and deep vessel density (DCP) of whole image, fovea and parafovea, the area and perimeter of fovea avascular area (FAZ), A-circularity index (AI, perimeter/standard circle perimeter with equal area) and vessel density around the 300 μm width of the FAZ (FD), central macular thickness (CMT) on macular 3 mm × 3 mm scan on OCTA were measured.Results:SCP and DCP of whole image ( F=10.774, 4.583) and parafovea ( F=10.433, 3.912), CMT ( F=171.940) in IRL group and non-IRL group on macular 3 mm × 3 mm scan on OCTA were significantly lower than that in normal persons ( P<0.05). There were significant differences among three groups of the area of FAZ ( F=4.315), AI ( F=3.413), FD-300 ( F=13.592) ( P<0.05). BCVA were worst in IRL group ( P<0.05). Conclusions:Blood flow density decreased in macular area of FEVR patients. CMT is significantly thicker than normal population. The FAZ area of the foveal IRL residual eyes is small and irregular, with worse BCVA and lower macular blood density.
ISSN	1005-1015
卷号	39 期号:7 页码:560-564
DOI	10.3760/cma.j.cn511434-20230210-00058
页数	5
收录类别	CSCD ; SCOPUS ; 维普 ; ISTIC ; 北大核心 ; ISTIC ; 万方
URL	查看原文
SCOPUSEID	2-s2.0-85174352621
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182629
专题	眼视光学院（生物医学工程学院）、附属眼视光医院_杭州院区
作者单位	1.杭州市中医院眼科,　杭州　310007; 2.温州医科大学附属眼视光医院杭州院区,　杭州　310020; 3.浙江省人民医院眼科,　杭州　310014
推荐引用方式 GB/T 7714	邵伊润,毛剑波,陈怡静,等. 家族性渗出性玻璃体视网膜病变伴黄斑中心凹内层视网膜残留患眼黄斑区结构及血流改变[J]. 中华眼底病杂志,2023,39(7):560-564.
APA	邵伊润, 毛剑波, 陈怡静, 方宇燕, & 沈丽君. (2023). 家族性渗出性玻璃体视网膜病变伴黄斑中心凹内层视网膜残留患眼黄斑区结构及血流改变. 中华眼底病杂志, 39(7), 560-564.
MLA	邵伊润,et al."家族性渗出性玻璃体视网膜病变伴黄斑中心凹内层视网膜残留患眼黄斑区结构及血流改变".中华眼底病杂志 39.7(2023):560-564.