科研成果详情

题名PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
作者
发表日期2023-08-18
发表期刊Molecular cancer   影响因子和分区
语种英语
原始文献类型Journal Article ; Review
关键词AKT inhibitors ATP-competitive mTOR inhibitors Allosteric mTOR inhibitors Bi-steric mTOR inhibitors Cancer Dual PI3K/mTOR inhibitors Isoform-specific PI3K inhibitors PDK1 inhibitors PI3K/AKT/mTORC pathway Pan PI3K inhibitors
其他关键词RENAL-CELL CARCINOMA ; FOXO TRANSCRIPTION FACTORS ; ADVANCED BREAST-CANCER ; PHASE-I TRIAL ; PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR ; NONFUNCTIONAL NEUROENDOCRINE TUMORS ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; INTRAVENOUS PI3K INHIBITOR ; PROTEIN-COUPLED RECEPTORS ; HEPATOCYTE GROWTH-FACTOR
摘要The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions with several other signaling pathways, and dysregulation of signal transduction can predispose to cancer development. The PAM axis is the most frequently activated signaling pathway in human cancer and is often implicated in resistance to anticancer therapies. Dysfunction of components of this pathway such as hyperactivity of PI3K, loss of function of PTEN, and gain-of-function of AKT, are notorious drivers of treatment resistance and disease progression in cancer. In this review we highlight the major dysregulations in the PAM signaling pathway in cancer, and discuss the results of PI3K, AKT and mTOR inhibitors as monotherapy and in co-administation with other antineoplastic agents in clinical trials as a strategy for overcoming treatment resistance. Finally, the major mechanisms of resistance to PAM signaling targeted therapies, including PAM signaling in immunology and immunotherapies are also discussed.
资助项目ingapore Ministry of Education [MOE-T2EP30120-0016]
出版者BMC
ISSN1476-4598
EISSN1476-4598
卷号22期号:1
DOI10.1186/s12943-023-01827-6
页数37
WOS类目Biochemistry & Molecular Biology ; Oncology
WOS研究方向Biochemistry & Molecular Biology ; Oncology
WOS记录号WOS:001050375700001
收录类别PUBMED ; SCIE ; SCOPUS
URL查看原文
PubMed ID37596643
SCOPUSEID2-s2.0-85168348160
ESI热点论文2024-05 ; 2024-07 ; 2024-09 ; 2024-11
ESI高被引论文2024-03 ; 2024-05 ; 2024-07 ; 2024-09
通讯作者地址[Kumar, Alan P.]Department of Surgery,National University Hospital Singapore,National University of Singapore,Singapore,Singapore
Scopus学科分类Molecular Medicine;Oncology;Cancer Research
TOP期刊TOP期刊
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/182457
专题其他_温州医科大学附属衢州医院
通讯作者Kumar, Alan P.
作者单位
1.Department of Biological,Chemical and Pharmaceutical Sciences and Technologies,University of Palermo,Palermo,90123,Italy;
2.Department of Surgery,National University Hospital Singapore,National University of Singapore,Singapore,Singapore;
3.Department of Pharmacology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,117600,Singapore;
4.NUS Centre for Cancer Research (N2CR),Yong Loo Lin School of Medicine,National University of Singapore,Singapore,119077,Singapore;
5.Department of Medical Oncology,Institut du Cancer de Montpellier,Inserm U1194,Montpellier University,Montpellier,France;
6.Cardiff University and Velindre Cancer Centre,Museum Avenue,Cardiff,CF10 3AX,United Kingdom;
7.Division of Molecular Medicine,St. John’s Research Institute,St. John’s Medical College,Bangalore,560034,India;
8.The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Zhejiang,Quzhou,324000,China;
9.Department of Pediatric and Adolescent Oncology,Gustave Roussy Cancer Center,Inserm U1015,Université Paris-Saclay,Paris,France;
10.Section of Hematology and Medical Oncology,Boston University and Boston Medical Center,Boston,United States;
11.Cancer Research UK Cambridge Centre,Hills Road,Cambridge,CB2 0QQ,United Kingdom;
12.Departments of Ophthalmology and Anatomy,Yong Loo Lin School of Medicine,National University of Singapore,and Neurobiology Programme,National University of Singapore,Singapore,Singapore;
13.Dana-Farber Cancer Institute,Harvard Medical School,Boston,United States;
14.Department of Biochemistry and Molecular Biology,Johns Hopkins School of Public Health,Baltimore,United States;
15.Division of Cancer,Imperial College London,Hammersmith Campus, Du Cane Road,London,W12 0NN,United Kingdom;
16.Department of Molecular Biology and Biochemistry,University of California,216 Sprague Hall,Irvine,United States
推荐引用方式
GB/T 7714
Glaviano, Antonino,Foo, Aaron S. C.,Lam, Hiu Y.,et al. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer[J]. Molecular cancer,2023,22(1).
APA Glaviano, Antonino., Foo, Aaron S. C.., Lam, Hiu Y.., Yap, Kenneth C. H.., Jacot, William., ... & Kumar, Alan P.. (2023). PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular cancer, 22(1).
MLA Glaviano, Antonino,et al."PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer".Molecular cancer 22.1(2023).

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