Alterations of The Salivary Microbiota in Gastroesophageal Reflux Disease

doi:10.1016/j.job.2023.08.005

科研成果详情

题名	Alterations of The Salivary Microbiota in Gastroesophageal Reflux Disease
作者	Qian, Jun 1; Yang, Meilin 2; Xu, Duiyue 2; Zhang, Gaosong 2; Cai, Youhong 3; Yang, Bin2; Wang, Xiying 3; Yu, Yanbo 3
发表日期	2023-08-16
发表期刊	Journal of oral biosciences 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	GERD Microbiota Salivary Streptococcus
其他关键词	ORAL MICROBIOME ; INFECTIONS ; DIVERSITY ; RISK
摘要	Gastroesophageal reflux disease (GERD) is among the most prevalent gastrointestinal disorders. The oral microbiota plays an important role in human health and may be altered by the presence of GERD. Here, we aimed to investigate the alterations of salivary microbiota in GERD patients., We collected clinical information and salivary samples from 60 individuals. All participants underwent combined pH/impedance monitoring measurement and submitted samples for salivary microbiota sequencing. According to acid exposure time and DeMeester score, participants were divided into two groups: GERD + (Group G) and GERD - (Group C)., There was no significant difference in alpha diversity between study groups. Regarding beta diversity, principal coordinate analysis plots indicated that the microbiota composition data of the participants were grouped within partial overlapping clusters. The statistical analysis of the distance matrices was performed using the Adonis test (p = 0.017). Based on linear discriminant analysis effect size, the relative abundances of the phylum Bacteroidetes, class Bacteroidia, order Bacteroidales, family Prevotellaceae, and genus unidentified_Prevotellaceae were enriched in Group G. Compared with Group C, the phylum Actinobacteria, classes unidentified_Actinobacteria and Bacilli, orders Micrococcales and Lactobacillales, families Micrococcaceae and Streptococcaceae, and genuses Rothia and Streptococcus were decreased in Group G. At the genus level, the abundances of Streptococcus and Rothia were negatively correlated with DeMeester score and acid exposure time., This study revealed alterations of the salivary microbiota in GERD patients, suggesting that acid reflux changes the oral ecosystem.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LGF19H030002]
出版者	ELSEVIER
ISSN	1349-0079
EISSN	1880-3865
卷号	65 期号:4 页码:280-286
DOI	10.1016/j.job.2023.08.005
页数	7
WOS类目	Dentistry, Oral Surgery & Medicine
WOS研究方向	Dentistry, Oral Surgery & Medicine
WOS记录号	WOS:001110196300001
收录类别	PUBMED ; SCOPUS ; ESCI
在线发表日期	2023-11
URL	查看原文
PubMed ID	37595742
SCOPUSEID	2-s2.0-85168501127
通讯作者地址	[Yu, Yanbo]Xinchang People's Hospital,117 Gushanzhong Road, Zhejiang,Shaoxing,312500,China ; [Wang, Xiying]Department of Geriatrics,Affiliated Xinchang Hospital,Wenzhou Medical University,Zhejiang,Shaoxing,312500,China
Scopus学科分类	Medicine (miscellaneous);Dentistry (all);Biochemistry, Genetics and Molecular Biology (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182455
专题	其他_附属新昌医院（新昌县人民医院）
通讯作者	Wang, Xiying; Yu, Yanbo
作者单位	1.Department of Colorectal Surgery,Affiliated Xinchang Hospital,Wenzhou Medical University,Zhejiang,Shaoxing,312500,China; 2.Department of Gastroenterology,Affiliated Xinchang Hospital,Wenzhou Medical University,Zhejiang,Shaoxing,312500,China; 3.Department of Geriatrics,Affiliated Xinchang Hospital,Wenzhou Medical University,Zhejiang,Shaoxing,312500,China
第一作者单位	其他_附属新昌医院（新昌县人民医院）
通讯作者单位	其他_附属新昌医院（新昌县人民医院）
第一作者的第一单位	其他_附属新昌医院（新昌县人民医院）
推荐引用方式 GB/T 7714	Qian, Jun,Yang, Meilin,Xu, Duiyue,et al. Alterations of The Salivary Microbiota in Gastroesophageal Reflux Disease[J]. Journal of oral biosciences,2023,65(4):280-286.
APA	Qian, Jun., Yang, Meilin., Xu, Duiyue., Zhang, Gaosong., Cai, Youhong., ... & Yu, Yanbo. (2023). Alterations of The Salivary Microbiota in Gastroesophageal Reflux Disease. Journal of oral biosciences, 65(4), 280-286.
MLA	Qian, Jun,et al."Alterations of The Salivary Microbiota in Gastroesophageal Reflux Disease".Journal of oral biosciences 65.4(2023):280-286.