Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction

doi:10.1016/j.isci.2023.107469

科研成果详情

题名	Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction
作者	Hou, Weibo1; Zong, Ming1,4; Zhao, Qi 2; Yang, Xu1; Zhang, Jiaming1,2; Liu, Shuanghui1; Li, Xuanwen1; Chen, Lijun1; Tang, Chun3; Wang, Xinyu 3; Dong, Zhixiong1; Gao, Meiling3; Su, Jianzhong2,3; Kong, Qingran1
发表日期	2023-08-18
发表期刊	iScience 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Epigenetics Machine learning Molecular biology Stem cells research
其他关键词	LONG NONCODING RNA ; TRANSCRIPTION ; SITES
摘要	Long non-coding RNAs (lncRNAs) have been implicated in diverse biological processes. However, the functional mechanisms have not yet been fully explored. Characterizing the interactions of lncRNAs with chromatin is central to determining their functions but, due to precise and efficient approaches lacking, our understanding of their functional mechanisms has progressed slowly. In this study, we demonstrate that a nuclear lncRNA linc1393 maintains mouse ESC pluripotency by recruiting SET1A near its binding sites, to establish H3K4me3 status and activate the expression of specific pluripotency-related genes. Moreover, we characterized the principles of lncRNA-chromatin interaction and transcriptional regulation. Accordingly, we developed a computational framework based on the XGBoost model, LncTargeter, to predict the targets of a given lncRNA, and validated its reliability in various cellular contexts. Together, these findings elucidate the roles and mechanisms of lncRNA on pluripotency maintenance, and provide a promising tool for predicting the regulatory networks of lncRNAs.
资助项目	Basic Public Welfare Research Program of Zhejiang Province; [LY22C120001]
出版者	CELL PRESS
ISSN	2589-0042
EISSN	2589-0042
卷号	26 期号:8
DOI	10.1016/j.isci.2023.107469
页数	19
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001053353400001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-08
URL	查看原文
PubMed ID	37588167
SCOPUSEID	2-s2.0-85169806840
通讯作者地址	[Gao, Meiling]School of Optometry and Ophthalmology and Eye Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Su, Jianzhong]Oujiang Laboratory,Zhejiang Lab for Regenerative Medicine,Vision and Brain Health,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Kong, Qingran]Oujiang Laboratory,Zhejiang Provincial Key Laboratory of Medical Genetics,Key Laboratory of Laboratory Medicine,Ministry of Education,School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182447
专题	检验医学院（生命科学学院、生物学实验教学中心）眼视光学院（生物医学工程学院）、附属眼视光医院其他_瓯江实验室
通讯作者	Gao, Meiling; Su, Jianzhong; Kong, Qingran
作者单位	1.Oujiang Laboratory,Zhejiang Provincial Key Laboratory of Medical Genetics,Key Laboratory of Laboratory Medicine,Ministry of Education,School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Oujiang Laboratory,Zhejiang Lab for Regenerative Medicine,Vision and Brain Health,Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.School of Optometry and Ophthalmology and Eye Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.College of Life Science,Northeast Agricultural University,Heilongjiang,Harbin,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）; 瓯江实验室
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院; 瓯江实验室; 检验医学院（生命科学学院、生物学实验教学中心）
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Hou, Weibo,Zong, Ming,Zhao, Qi,et al. Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction[J]. iScience,2023,26(8).
APA	Hou, Weibo., Zong, Ming., Zhao, Qi., Yang, Xu., Zhang, Jiaming., ... & Kong, Qingran. (2023). Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction. iScience, 26(8).
MLA	Hou, Weibo,et al."Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction".iScience 26.8(2023).