题名 | Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers |
作者 | |
发表日期 | 2023-10 |
发表期刊 | Clinical immunology (Orlando, Fla.) 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Journal Article |
关键词 | Diagnostic model Gene expression Major salivary gland ultrasonography Primary Sjögren's syndrome RNA sequencing |
其他关键词 | RHEUMATOLOGY CLASSIFICATION CRITERIA ; MAJOR SALIVARY-GLANDS ; RESISTANCE PROTEIN-A ; INTERFERON TYPE-I ; AMERICAN-COLLEGE ; GENE-EXPRESSION ; DATA-DRIVEN ; CONSENSUS ; PERFORMANCE ; ULTRASOUND |
摘要 | Diagnosing primary Sjögren's syndrome (pSS) is difficult due to clinical heterogeneity and the absence of non-invasive specific biomarkers. To develop non-invasive pSS diagnosis methods that integrate classic clinical indexes, major salivary gland ultrasonography (SGUS), and gene expression profiles shared by labial gland and peripheral blood, we conducted a study on a cohort of 358 subjects. We identified differentially expressed genes (DEGs) in glands and blood that were enriched in defense response to virus and type I interferon production pathways. Four upregulated DEGs common in glands and blood were identified as hub genes based on the protein-protein interaction networks. A random forest model was trained using features, including SGUS, anti-SSA/Ro60, keratoconjunctivitis sicca tests, and gene expression levels of MX1 and RSAD2. The model achieved comparable pSS diagnosis accuracy to the golden standard method based on labial gland biopsy. Our findings implicate this novel model as a promising diagnosis technique of pSS. |
资助项目 | National Natural Science Foundation of China [82271816] ; Medical and Health Science and Technology project of Zhejiang Province [2021RC090] |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
ISSN | 1521-6616 |
EISSN | 1521-7035 |
卷号 | 255 |
DOI | 10.1016/j.clim.2023.109739 |
页数 | 11 |
WOS类目 | Immunology |
WOS研究方向 | Immunology |
WOS记录号 | WOS:001068343300001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
在线发表日期 | 2023-08 |
URL | 查看原文 |
PubMed ID | 37586671 |
SCOPUSEID | 2-s2.0-85168818395 |
通讯作者地址 | [Wang, Xiaobing]Department of Rheumatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China,Department of Rheumatology and Immunology,Shanghai Changzheng Hospital,Second Affiliated Hospital of Naval Medical University,Wenzhou,China ; [Li, Zhongshan]Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou,China ; [Xu, Shihao]Department of Ultrasonography,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
Scopus学科分类 | Immunology and Allergy;Immunology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/182444 |
专题 | 附属第一医院 基因组医学研究院 |
通讯作者 | Xu, Shihao; Li, Zhongshan; Wang, Xiaobing |
作者单位 | 1.Department of Ultrasonography,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Rheumatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Rheumatology and Immunology,Shanghai Changzheng Hospital,Second Affiliated Hospital of Naval Medical University,Shanghai,200001,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者单位 | 附属第一医院; 附属第二医院; 第一临床医学院(信息与工程学院)、附属第一医院; 基因组医学研究院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Xu, Shihao,Zhu, Chengwei,Jiang, Jiachun,et al. Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers[J]. Clinical immunology (Orlando, Fla.),2023,255. |
APA | Xu, Shihao., Zhu, Chengwei., Jiang, Jiachun., Hui, Cheng., Wang, Ping., ... & Wang, Xiaobing. (2023). Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers. Clinical immunology (Orlando, Fla.), 255. |
MLA | Xu, Shihao,et al."Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers".Clinical immunology (Orlando, Fla.) 255(2023). |
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