科研成果详情

题名Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers
作者
发表日期2023-10
发表期刊Clinical immunology (Orlando, Fla.)   影响因子和分区
语种英语
原始文献类型Journal Article
关键词Diagnostic model Gene expression Major salivary gland ultrasonography Primary Sjögren's syndrome RNA sequencing
其他关键词RHEUMATOLOGY CLASSIFICATION CRITERIA ; MAJOR SALIVARY-GLANDS ; RESISTANCE PROTEIN-A ; INTERFERON TYPE-I ; AMERICAN-COLLEGE ; GENE-EXPRESSION ; DATA-DRIVEN ; CONSENSUS ; PERFORMANCE ; ULTRASOUND
摘要

Diagnosing primary Sjögren's syndrome (pSS) is difficult due to clinical heterogeneity and the absence of non-invasive specific biomarkers. To develop non-invasive pSS diagnosis methods that integrate classic clinical indexes, major salivary gland ultrasonography (SGUS), and gene expression profiles shared by labial gland and peripheral blood, we conducted a study on a cohort of 358 subjects. We identified differentially expressed genes (DEGs) in glands and blood that were enriched in defense response to virus and type I interferon production pathways. Four upregulated DEGs common in glands and blood were identified as hub genes based on the protein-protein interaction networks. A random forest model was trained using features, including SGUS, anti-SSA/Ro60, keratoconjunctivitis sicca tests, and gene expression levels of MX1 and RSAD2. The model achieved comparable pSS diagnosis accuracy to the golden standard method based on labial gland biopsy. Our findings implicate this novel model as a promising diagnosis technique of pSS.

资助项目National Natural Science Foundation of China [82271816] ; Medical and Health Science and Technology project of Zhejiang Province [2021RC090]
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN1521-6616
EISSN1521-7035
卷号255
DOI10.1016/j.clim.2023.109739
页数11
WOS类目Immunology
WOS研究方向Immunology
WOS记录号WOS:001068343300001
收录类别SCIE ; PUBMED ; SCOPUS
在线发表日期2023-08
URL查看原文
PubMed ID37586671
SCOPUSEID2-s2.0-85168818395
通讯作者地址[Wang, Xiaobing]Department of Rheumatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China,Department of Rheumatology and Immunology,Shanghai Changzheng Hospital,Second Affiliated Hospital of Naval Medical University,Wenzhou,China ; [Li, Zhongshan]Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou,China ; [Xu, Shihao]Department of Ultrasonography,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类Immunology and Allergy;Immunology
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/182444
专题附属第一医院
基因组医学研究院
通讯作者Xu, Shihao; Li, Zhongshan; Wang, Xiaobing
作者单位
1.Department of Ultrasonography,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
2.Department of Rheumatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
3.Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou,325000,China;
4.Department of Rheumatology and Immunology,Shanghai Changzheng Hospital,Second Affiliated Hospital of Naval Medical University,Shanghai,200001,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
通讯作者单位附属第一医院;  附属第二医院;  第一临床医学院(信息与工程学院)、附属第一医院;  基因组医学研究院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Xu, Shihao,Zhu, Chengwei,Jiang, Jiachun,et al. Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers[J]. Clinical immunology (Orlando, Fla.),2023,255.
APA Xu, Shihao., Zhu, Chengwei., Jiang, Jiachun., Hui, Cheng., Wang, Ping., ... & Wang, Xiaobing. (2023). Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers. Clinical immunology (Orlando, Fla.), 255.
MLA Xu, Shihao,et al."Non-invasive diagnosis of primary Sjögren's syndrome using ultrasonography and transcriptome biomarkers".Clinical immunology (Orlando, Fla.) 255(2023).

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