Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects

doi:10.1097/IJG.0000000000002225

科研成果详情

题名	Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects
作者	Lin, Sigeng 1,2; Zhang, Shaodan 1,2; Shang, Xiao 1,2; Gu, Juan 1,2; Ye, Cong 1,2; Wang, Xiaoyan 1,2; Zhou, Kun 1,2; Kong, Yu Xiang George 3,4,5; Liang, Yuanbo 1,2
发表日期	2023-08
发表期刊	Journal of glaucoma 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, Non-U.S. Gov't
关键词	macular vessel density single-hemifield visual field defect primary open angle glaucoma
其他关键词	RETINAL NERVE-FIBER ; OPEN-ANGLE GLAUCOMA ; INNER PLEXIFORM LAYER ; BLOOD-FLOW ; PERIPAPILLARY ; EYES ; MICROCIRCULATION ; THICKNESS ; DAMAGE ; RATES
摘要	Faster hemispheric mVD loss was found in the affected hemifield of POAG patients without significant changes in hemispheric thickness. The progression of mVD loss was associated with the severity of VF damage., To evaluate the changes in macular vessel density (mVD) loss in primary open angle glaucoma (POAG) patients with visual field (VF) defects confined to 1 hemifield., This longitudinal cohort study used linear mixed models to evaluate the changes in the hemispheric mean total deviation (mTD), mVD, macular ganglion cell complex, macular ganglion cell-inner plexiform layer, and retinal nerve fiber layer between affected hemifields, unaffected hemifields, and healthy controls., Twenty-nine POAG eyes and 25 healthy eyes were followed for an average of 29 months. In POAG eyes, the rates of decline in hemispheric mTD and hemispheric mVD in the affected hemifields were significantly faster than those in the unaffected hemifields (-0.42±1.24 vs. 0.02±0.69 dB/year, P =0.018 and -2.16±1.01 vs. -1.77±0.90% / year, P =0.031, respectively). There were no differences in the rate of hemispheric thickness change between the 2 hemifields. The rate of hemispheric mVD decline in both hemifields of POAG eyes was significantly faster than that of the healthy controls (All P <0.05). An association between the reduced mTD of the VF and the rate of hemispheric mVD loss in the affected hemifield was observed (r=0.484, P =0.008). Faster rates of mVD loss (β=-1.72±0.80, P =0.050) were significantly related to reduced hemispheric mTD in the multivariate analysis., Faster hemispheric mVD loss was found in the affected hemifield of POAG patients without significant changes in hemispheric thickness. The progression of mVD loss was associated with the severity of VF damage.
资助项目	Key Research and Development Program of Zhejiang[2022C03112];National Key R&D Program of China[2020YFC2008200];
出版者	LIPPINCOTT WILLIAMS & WILKINS
ISSN	1057-0829
EISSN	1536-481X
卷号	32 期号:8 页码:658-664
DOI	10.1097/IJG.0000000000002225
页数	7
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:001047968600006
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37054404
SCOPUSEID	2-s2.0-85168221911
通讯作者地址	[Liang, Yuanbo]Eye Hospital and School of Ophthalmology and Optometry,Wenzhou Medical University,No. 270 West College Road, Zhejiang, Wenzhou, Zhejiang,Wenzhou,325000,China
Scopus学科分类	Ophthalmology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182404
专题	眼视光学院（生物医学工程学院）、附属眼视光医院_青光眼专科青光眼早期诊断与随访检测中心
通讯作者	Liang, Yuanbo
作者单位	1.Eye Hospital and School of Ophthalmology and Optometry,Wenzhou Medical University,China; 2.National Clinical Research Center for Ocular Diseases,Zhejiang,Wenzhou,China; 3.Department of Ophthalmology,The University of Melbourne,Parkville,Melbourne,Australia; 4.Royal Victorian Eye and Ear Hospital,East Melbourne,Australia; 5.Centre for Eye Research Australia,Australia
推荐引用方式 GB/T 7714	Lin, Sigeng,Zhang, Shaodan,Shang, Xiao,et al. Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects[J]. Journal of glaucoma,2023,32(8):658-664.
APA	Lin, Sigeng., Zhang, Shaodan., Shang, Xiao., Gu, Juan., Ye, Cong., ... & Liang, Yuanbo. (2023). Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects. Journal of glaucoma, 32(8), 658-664.
MLA	Lin, Sigeng,et al."Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects".Journal of glaucoma 32.8(2023):658-664.