Reactive Oxygen Species-Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease

doi:10.1002/adfm.202304381

科研成果详情

题名	Reactive Oxygen Species-Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease
作者	Zeng, Youyun1; Fan, Mengni 1; Zhou, Qiang 2; Chen, Dongfan 1; Jin, Ting1; Mu, Zhixiang1; Li, Lin 1; Chen, Jiale 1; Qiu, Dongchao1; Zhang, Yanmei1; Pan, Yihuai1; Shen, Xinkun2; Cai, Xiaojun1
发表日期	2023-07-28
发表期刊	ADVANCED FUNCTIONAL MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	carbon monoxide gas therapy colitis gut microbiota immunoregulation peptide dendrimer nanogels
其他关键词	FLUORINATED PEPTIDE DENDRIMERS ; DRUG-DELIVERY SYSTEMS ; CARBON-MONOXIDE ; HEME OXYGENASE-1 ; HIGHLY EFFICIENT ; KAPPA-B ; MACROPHAGES ; KINASE ; PHENOTYPE ; MODELS
摘要	Abnormal activation of the gut mucosal immune system and a highly dysregulated gut microbiota play essential roles in the progression of inflammatory bowel disease (IBD). The clinical treatment of IBD remains highly challenging, with first-line drugs showing limited efficacy and significant side effects. A reactive oxygen species (ROS)-activated CO versatile nanomedicine (CMPs) capable of remodeling the gut immune-microbiota microenvironment via potent anti-oxidant, anti-inflammatory, and antimicrobial effects is developed. CORM-401-loaded mannose-modified peptide dendrimer nanogel: CMPs preferentially congregate on the surface of damaged colon mucosa after rectal administration and are subsequently internalized by activated immune cells. CORM-401 can release numerous CO molecules in response to high ROS levels in cells and at the site of IBD, resulting in multiple therapeutic effects. In vitro and in vivo studies have demonstrated that CMPs scavenge ROS, suppress inflammatory responses, eliminate pathogens, and alleviate colitis in mouse models. RNA sequencing reveals that CMPs successfully remodel gut mucosal immune homeostasis by scavenging ROS, inhibiting NF-& kappa;B/p38MAPK, activating PI3K-Akt, and inhibiting HIF-1-induced glycolysis. 16S ribosomal RNA sequencing shows that CMPs can remodel the gut flora composition by restraining detrimental bacteria and augmenting beneficial bacteria. This study develops a promising and versatile nanomedicine for the management of IBD.
资助项目	National Natural Science Foundation of China [82272150]; Zhejiang Public Welfare Science and Technology Project [LGF22E030010]; Medicine and Health Science and Technology Plan Projects in Zhejiang province [2022RC212]
出版者	WILEY-V C H VERLAG GMBH
ISSN	1616-301X
EISSN	1616-3028
卷号	33 期号:49
DOI	10.1002/adfm.202304381
页数	19
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号	WOS:001036288900001
收录类别	SCIE ; SCOPUS ; EI
在线发表日期	2023-07
EI入藏号	20233114465999
EI主题词	Oxygen
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 761 Nanotechnology ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 933.1 Crystalline Solids
URL	查看原文
SCOPUSEID	2-s2.0-85175109729
自科自定义期刊分类	T3(A)类
通讯作者地址	[Pan, Yihuai]School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China ; [Cai, Xiaojun]School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China ; [Shen, Xinkun]Ruian People's Hospital,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,325016,China
Scopus学科分类	Electronic, Optical and Magnetic Materials;Chemistry (all);Biomaterials;Materials Science (all);Condensed Matter Physics;Electrochemistry
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182376
专题	口腔医学院、附属口腔医院其他_附属第三医院（瑞安市人民医院）
通讯作者	Pan, Yihuai; Shen, Xinkun; Cai, Xiaojun
作者单位	1.School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China; 2.Ruian People's Hospital,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,325016,China
第一作者单位	口腔医学院、附属口腔医院
通讯作者单位	口腔医学院、附属口腔医院; 其他_附属第三医院（瑞安市人民医院）
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Zeng, Youyun,Fan, Mengni,Zhou, Qiang,et al. Reactive Oxygen Species-Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease[J]. ADVANCED FUNCTIONAL MATERIALS,2023,33(49).
APA	Zeng, Youyun., Fan, Mengni., Zhou, Qiang., Chen, Dongfan., Jin, Ting., ... & Cai, Xiaojun. (2023). Reactive Oxygen Species-Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease. ADVANCED FUNCTIONAL MATERIALS, 33(49).
MLA	Zeng, Youyun,et al."Reactive Oxygen Species-Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease".ADVANCED FUNCTIONAL MATERIALS 33.49(2023).