Current trends of high-risk gene Cul3 in neurodevelopmental disorders

doi:10.3389/fpsyt.2023.1215110

科研成果详情

题名	Current trends of high-risk gene Cul3 in neurodevelopmental disorders
作者	Lin, Ping 1; Yang, Jie 1; Wu, Shumin 1; Ye, Tong1; Zhuang, Wenting1; Wang, Wei1,2; Tan, Tao1
发表日期	2023-07-28
发表期刊	FRONTIERS IN PSYCHIATRY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Cul3 Cullin3-RING E3 ubiquitin ligases neurodevelopmental disorders (NDDs) autism spectrum disorder (ASD) knockout (KO) mice
其他关键词	PROTEIN NETWORK ; AUTISM ; MUTATIONS ; INSIGHTS ; CORTEX ; MICE ; NEOCORTEX ; BEHAVIOR ; RHOA
摘要	Cul3 encodes Cullin-3, a core component of the ubiquitin E3 ligase that is involved in protein ubiquitination. Recent studies have identified Cul3 as a high-confidence risk gene in neurodevelopmental disorders (NDDs), especially autism spectrum disorder (ASD). Different strategies have been used to generate animal models with Cul3 deficiency in the central nervous system, including whole-brain knockout (KO), cell-type specific conditional KO (cKO), and brain region-specific knockdown. In this review, we revisited the basic properties of CUL3 and its function under physiological and pathological conditions. Recent clinical studies including case reports and large cohort sequencing studies related to CUl3 in NDDs have been summarized. Moreover, we characterized the behavioral, electrophysiological, and molecular changes in newly developed Cul3 deficiency models. This would guide further studies related to Cul3 in CNS and provide potential therapeutic targets for Cul3-deficiency-induced NDDs, including ASD.
资助项目	Science Foundation of Oujiang Laboratory [OJQD2022002]
出版者	FRONTIERS MEDIA SA
ISSN	1664-0640
卷号	14
DOI	10.3389/fpsyt.2023.1215110
页数	12
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:001045992800001
收录类别	SCIE ; PUBMED ; SCOPUS ; SSCI
URL	查看原文
PubMed ID	37575562
SCOPUSEID	2-s2.0-85167601145
通讯作者地址	[Tan, Tao]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Psychiatry and Mental Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182334
专题	卓越中心_老年研究院
通讯作者	Tan, Tao
作者单位	1.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Neuroscience,Baylor College of Medicine,Houston,United States
第一作者单位	卓越中心_老年研究院
通讯作者单位	卓越中心_老年研究院
第一作者的第一单位	卓越中心_老年研究院
推荐引用方式 GB/T 7714	Lin, Ping,Yang, Jie,Wu, Shumin,et al. Current trends of high-risk gene Cul3 in neurodevelopmental disorders[J]. FRONTIERS IN PSYCHIATRY,2023,14.
APA	Lin, Ping., Yang, Jie., Wu, Shumin., Ye, Tong., Zhuang, Wenting., ... & Tan, Tao. (2023). Current trends of high-risk gene Cul3 in neurodevelopmental disorders. FRONTIERS IN PSYCHIATRY, 14.
MLA	Lin, Ping,et al."Current trends of high-risk gene Cul3 in neurodevelopmental disorders".FRONTIERS IN PSYCHIATRY 14(2023).