Amygdalin Inhibits Cell Proliferation, Migration and Invasion in Thyroid Cancer by Regulating CircWHSC1/miR-195-5p

科研成果详情

题名	Amygdalin Inhibits Cell Proliferation, Migration and Invasion in Thyroid Cancer by Regulating CircWHSC1/miR-195-5p
作者	Zhang, Xicai 1; Lin, Shu2,3; Quan, Zijiao 4; Zhu, Xiaozhen2,3
发表日期	2023-05
发表期刊	INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Amygdalin thyroid cancer circWHSC1 miR-195-5p proliferation
其他关键词	MIR-195-5P ; APOPTOSIS ; CHEMORESISTANCE ; PROGRESSION
摘要	To probe the functions of amygdalin on thyroid cancer cells and further analyze whether its mechanism is related to regulating circWHSC1 and miR-195-5p expression. The relative levels of circWHSC1 and miR195-5p in cells were analyzed by reverse transcription-quantitative polymerase chain reaction. Effects of amygdalin on thyroid cancer cell lines were calculated. Dual luciferase report assay was applied to ensure the targeting between circWHSC1 and miR-195-5p. The level of circWHSC1 was increased, while the level of miR-195-5p was declined in thyroid cancer tissues. Amygdalin treatment dose-dependently reduced cell viability, suppressed cell invasion, migration and colony formation abilities. Amygdalin treatment reduced the level of circWHSC1, as well as increased the level of miR-195-5p. CircWHSC1 directly bound to miR-195-5p. CircWHSC1 inhibition notably restrained cell growth and mobility in thyroid cancer. Moreover, circWHSC1 overexpression abated the suppressing functions of amygdalin on thyroid cancer cell proliferative, migratory and invasive abilities. Amygdalin inhibited cell proliferative, migratory and invasive abilities in thyroid cancer via circWHSC1/miR-195-5p axis.
出版者	INDIAN PHARMACEUTICAL ASSOC
ISSN	0250-474X
EISSN	1998-3743
卷号	85 期号:3 页码:761-768
页数	8
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001027246400022
收录类别	SCIE
通讯作者地址	[Zhu, Xiaozhen]Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharmaceut, Wenzhou 325000, Peoples R China. ; [Zhu, Xiaozhen]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182333
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学附属第二医院第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Zhu, Xiaozhen
作者单位	1.Wenzhou Med Univ, Pingyang Hosp, Dept Gen Surg, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharmaceut, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China; 4.Wenzhou Univ, Coll Life & Environm Sci, Whenzhou 325000, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学
推荐引用方式 GB/T 7714	Zhang, Xicai,Lin, Shu,Quan, Zijiao,et al. Amygdalin Inhibits Cell Proliferation, Migration and Invasion in Thyroid Cancer by Regulating CircWHSC1/miR-195-5p[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2023,85(3):761-768.
APA	Zhang, Xicai, Lin, Shu, Quan, Zijiao, & Zhu, Xiaozhen. (2023). Amygdalin Inhibits Cell Proliferation, Migration and Invasion in Thyroid Cancer by Regulating CircWHSC1/miR-195-5p. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 85(3), 761-768.
MLA	Zhang, Xicai,et al."Amygdalin Inhibits Cell Proliferation, Migration and Invasion in Thyroid Cancer by Regulating CircWHSC1/miR-195-5p".INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 85.3(2023):761-768.