Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma

doi:10.3389/fphar.2023.1203125

科研成果详情

题名	Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma
作者	Wang, Quanqiang1; Zhao, Misheng 2; Zhang, Tianyu1; Zhang, Bingxin1; Zheng, Ziwei1; Lin, Zhili1; Zhou, Shujuan1; Zheng, Dong 1; Chen, Zixing3; Zheng, Sisi 1; Zhang, Yu 1; Lin, Xuanru1; Dong, Rujiao1; Chen, Jingjing1; Qian, Honglan1; Hu, Xudong1; Zhuang, Yan1; Zhang, Qianying 1; Jiang, Songfu1; Ma, Yongyong1,4,5
发表日期	2023-08-07
发表期刊	FRONTIERS IN PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	multiple myeloma ferroptosis prognostic marker genes overall survival gene set enrichment analysis drug sensitivity immune analysis
其他关键词	INTERNATIONAL STAGING SYSTEM ; CD4(+) T-CELLS ; UP-REGULATION ; EXPRESSION ; P21
摘要	Background: One particular type of cellular death that is known as ferroptosis is caused by the excessive lipid peroxidation. It is a regulated form of cell death that can affect the response of the tumor cells. Currently, it is not known if the presence of this condition can affect the prognosis of patients with multiple myeloma (MM).Methods: In this study, we studied the expression differences and prognostic value of ferroptosis-related genes (FRGs) in MM, and established a ferroptosis risk scoring model. In order to improve the prediction accuracy and clinical applicability, a nomogram was also established. Through gene enrichment analysis, pathways closely related to high-risk groups were identified. We then explored the differences in risk stratification in drug sensitivity and immune patterns, and evaluated their value in prognostic prediction and treatment response. Lastly, we gathered MM cell lines and samples from patients to confirm the expression of marker FRGs using quantitative real-time PCR (qRT-PCR).Results: The ability to predict the survival of MM patients is a challenging issue. Through the use of a risk model derived from ferroptosis, we were able to develop a more accurate prediction of the disease's prognosis. They were then validated by a statistical analysis, which showed that the model is an independent factor in the prognosis of MM. Patients of high ferroptosis risk scores had a much worse chance of survival than those in the low-risk groups. The calibration and power of the nomogram were also strong. We noted that the link between the ferroptosis risk score and the clinical treatment was suggested by the FRG's significant correlation with the immune checkpoint genes and the medication sensitivity. We validated the predictive model using qRT-PCR.Conclusion: We demonstrated the association between FRGs and MM, and developed a new risk model for prognosis in MM patients. Our study sheds light on the potential clinical relevance of ferroptosis in MM and highlights its potential as a therapeutic target for patients with this disease.
资助项目	National Natural Science Foundation [82270212]; Natural Science Foundation of Zhejiang province [LY20H080003]; Wenzhou Municipal Science and Technology Bureau [Y20220716]
出版者	FRONTIERS MEDIA SA
ISSN	1663-9812
EISSN	1663-9812
卷号	14
DOI	10.3389/fphar.2023.1203125
页数	15
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001051435300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37608887
SCOPUSEID	2-s2.0-85168316119
通讯作者地址	[Jiang, Songfu]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Ma, Yongyong]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182324
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Jiang, Songfu; Ma, Yongyong
作者单位	1.Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Clinical Laboratory,Wenzhou People’s Hospital,Wenzhou,China; 3.Department of Hepatobiliary Surgery,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province,Zhejiang,Wenzhou,China; 5.Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization,Zhejiang,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Quanqiang,Zhao, Misheng,Zhang, Tianyu,et al. Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma[J]. FRONTIERS IN PHARMACOLOGY,2023,14.
APA	Wang, Quanqiang., Zhao, Misheng., Zhang, Tianyu., Zhang, Bingxin., Zheng, Ziwei., ... & Ma, Yongyong. (2023). Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma. FRONTIERS IN PHARMACOLOGY, 14.
MLA	Wang, Quanqiang,et al."Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma".FRONTIERS IN PHARMACOLOGY 14(2023).