Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease

doi:10.2147/COPD.S408361

科研成果详情

题名	Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease
作者	Yang, Chengyu 1,2; Yang, Li3,4; Yang, Lei 5; Li, Shuiming 5; Ye, Ling 1,6; Ye, Jinfeng 5; Chen, Chengshui3,4,7; Zeng, Yiming 8; Zhu, Mengchan 1; Lin, Xiaoping 8; Peng, Qing 9; Wang, Yun 5,10; Jin, Meiling 1,6
发表日期	2023
发表期刊	INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	chronic obstructive pulmonary disease frequent exacerbation data -independent acquisition proteomics bioinformatics analysis
其他关键词	INDEPENDENT ACQUISITION ; COPD PATIENTS ; RISK ; POLYMORPHISMS ; PATHOGENESIS ; ASSOCIATION ; GENE
摘要	Background: Frequent exacerbation (FE) and infrequent exacerbation (IE) are two phenotypes of chronic obstructive pulmonary disease (COPD), of which FE is associated with a higher incidence of exacerbation and a serious threat to human health. Because the pathogenesis mechanisms of FE are unclear, this study aims to identify FE-related proteins in the plasma via proteomics for use as predictive, diagnostic, and therapeutic biomarkers of COPD.Methods: A cross-sectional study was conducted in which plasma protein profiles were analyzed in COPD patients at stable stage, and differentially expressed proteins (DEPs) were screened out between the FE and IE patients. FE-related DEPs were identified using data-independent acquisition-based proteomics and bioinformatics analyses. In addition, FE-related candidates were verified by enzyme-linked immunosorbent assay.Results: In this study, 47 DEPs were screened out between the FE and IE groups, including 20 upregulated and 27 downregulated proteins. Key biological functions (eg, neutrophil degranulation, extracellular exosome, protein homodimerization activity) and signaling pathways (eg, arginine and proline metabolism) were enriched in association with the FE phenotype. Receiver operating characteristic (ROC) analysis of the 11 combined DEPs revealed an area under the curve of 0.985 (p <0.05) for discriminating FE from IE. Moreover, correlation and ROC curve analyses indicated that creatine kinase, M-type (CKM) and fat storage-inducing transmembrane protein 1 (FITM1) might be clinically significant in patients with the FE phenotype. In addition, plasma expression levels of CKM and FITM1 were validated to be significantly decreased in the FE group compared with the IE group (CKM:p <0.01; FITM1: p <0.05).Conclusion: In this study, novel insights into COPD pathogenesis were provided by investigating and comparing plasma protein profiles between the FE and IE patients. CKM, FITM1, and a combinative biomarker panel may serve as useful tools for assisting in the precision diagnosis and effective treatment of the FE phenotype of COPD.
资助项目	Shenzhen Basic Research Program of Science and Technology Innovation Commission [JCYJ20190808122413582]; Shanghai Natural Science Foundation [22ZR1411100]; National Research amp; Development Program [2016YFC1304000, 2016YFC1304002]
出版者	DOVE MEDICAL PRESS LTD
ISSN	1178-2005
EISSN	1178-2005
卷号	18 页码:1713-1728
DOI	10.2147/COPD.S408361
页数	16
WOS类目	Respiratory System
WOS研究方向	Respiratory System
WOS记录号	WOS:001048161900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37581107
SCOPUSEID	2-s2.0-85167900141
通讯作者地址	[Wang, Yun]Longhua Innovation Institute for Biotechnology,Shenzhen University,Guangdong,Shenzhen,518055,China ; [Jin, Meiling]Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Fudan University,Shanghai,200032,China
Scopus学科分类	Pulmonary and Respiratory Medicine;Health Policy;Public Health, Environmental and Occupational Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/182275
专题	附属第一医院其他_温州医科大学附属衢州医院
通讯作者	Wang, Yun; Jin, Meiling
作者单位	1.Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Fudan University,Shanghai,200032,China; 2.Department of Pulmonary and Critical Care Medicine,Huadong Hospital,Fudan University,Shanghai,200040,China; 3.Department of Pulmonary and Critical Care Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China; 4.Key Laboratory of Interventional Pulmonology of Zhejiang Province,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China; 5.Longhua Innovation Institute for Biotechnology,Shenzhen University,Guangdong,Shenzhen,518055,China; 6.Department of Allergy,Zhongshan Hospital,Fudan University,Shanghai,200032,China; 7.Department of Pulmonary and Critical Care Medicine,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Zhejiang,324000,China; 8.Department of Pulmonary and Critical Care Medicine,the Second Affiliated Hospital of Fujian Medical University,Respiratory Medicine Center of Fujian Province,Fujian,Quanzhou,362000,China; 9.Department of Pulmonary and Critical Care Medicine,Minhang Hospital,Fudan University,Shanghai,201199,China; 10.Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology,Shantou University Medical College,Guangdong,Shantou,515041,China
推荐引用方式 GB/T 7714	Yang, Chengyu,Yang, Li,Yang, Lei,et al. Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease[J]. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,2023,18:1713-1728.
APA	Yang, Chengyu., Yang, Li., Yang, Lei., Li, Shuiming., Ye, Ling., ... & Jin, Meiling. (2023). Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 18, 1713-1728.
MLA	Yang, Chengyu,et al."Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease".INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 18(2023):1713-1728.