Personalized cancer avatars for patients with thymic malignancies: A pilot study with circulating tumor cell-derived organoids

doi:10.1111/1759-7714.15039

科研成果详情

题名	Personalized cancer avatars for patients with thymic malignancies: A pilot study with circulating tumor cell-derived organoids
作者	Wu, Yuan-Hung 1,2,3; Chao, Heng-sheng 2,4; Chiang, Chi-Lu 2,4; Luo, Yung-Hung 2,4; Chiu, Chao-Hua 4,5; Yen, Sang-Hue 1,3,6; Liu, Chun-Yu 1,2; Chiou, Jeng-Fong 7,8,9; Burnouf, Thierry 10,11; Chen, Yin-Ju 9,10,11,12,13; Wang, Peng-Yuan 14,15; Chao, Tsu-Yi 16,17,18,19; Hsu, Shih-Ming 3; Lu, Long-Sheng 9,10,11,12
发表日期	2023-09
发表期刊	Thoracic cancer 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	circulating tumor cell organoid thymic carcinoma thymic malignancy thymoma
其他关键词	PHASE-II ; CARBOPLATIN ; CHEMOTHERAPY ; PACLITAXEL ; CARCINOMA ; CULTURE ; THYMOMA ; DISEASE
摘要	Systemic therapy is the primary treatment for advanced thymic malignancies. However, there is an urgent need to improve clinical outcome. Personalized treatment based on predictive biomarkers is a potential approach to address this requirement. In this study, we aimed to show the correlation between drug sensitivity tests on CTCs-derived organoids and clinical response in patients with thymic malignancies. This approach carries the potential to create personalized cancer avatars and improve treatment outcome for patients., We previously reported potential treatment outcome prediction with patient-derived organoids (cancer avatars) in patients with pancreatic ductal adenocarcinoma. To further investigate the feasibility of this approach in advanced thymic malignancies, we conducted a study in which 12 patients were enrolled and 21 liquid biopsies were performed., Cancer avatars were successfully derived in 16 out of 21 samples (success rate 76.2%). We found a sensitivity of 1.0 and specificity of 0.6 for drug sensitivity tests on the cancer avatars, and a two-tailed Fisher's exact test revealed a significant correlation between drug sensitivity tests and clinical responses (p = 0.0275)., This study supports the potential of circulating tumor cell-derived organoids to inform personalized treatment for advanced thymic malignancies. Further validation of this proof of concept finding is ongoing.
资助项目	Ministry of Education in Taiwan[DP2-110-21121-03-C-06-01];Ministry of Education in Taiwan[DP2-110-21121-03-C-06-02];Ministry of Education in Taiwan[DP2-110-21121-03-C-06-03];Ministry of Education in Taiwan[DP2-109-21121-03-C-06-01];Ministry of Education in Taiwan[DP2-109-21121-03-C-06-02];Ministry of Education in Taiwan[DP2-109-21121-03-C-06-03];Ministry of Science and Technology, Taiwan[MOST-111-2923-B-038-001-MY3];Ministry of Science and Technology, Taiwan[MOST-111-2314-B-038-070-MY3];Ministry of Science and Technology, Taiwan[MOST-110-2320-B-038-056];Ministry of Science and Technology, Taiwan[MOST-110-2314-B-038-138];Ministry of Science and Technology, Taiwan[MOST-109-2314-B-038-122];Ministry of Science and Technology, Taiwan[MOST-109-2314-B-038-141];Ministry of Science and Technology, Taiwan[MOST-109-2635-B-038-001];Ministry of Science and Technology, Taiwan[MOST-109-2314-B-038-072];National Health Research Institutes[NHRI-EX109-10713EI];Taipei Medical University[TMU105-AE1-B13]
出版者	WILEY
ISSN	1759-7706
EISSN	1759-7714
卷号	14 期号:25 页码:2591-2600
DOI	10.1111/1759-7714.15039
页数	10
WOS类目	Oncology ; Respiratory System
WOS研究方向	Oncology ; Respiratory System
WOS记录号	WOS:001033632300001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-07
URL	查看原文
PubMed ID	37474689
SCOPUSEID	2-s2.0-85165553925
通讯作者地址	[Hsu, Shih-Ming]Department of Biomedical Imaging and Radiological Sciences,National Yang-Ming Chiao-Tung University,Taipei,Taiwan ; [Lu, Long-Sheng]TMU Research Center of Cancer Translational Medicine,Taipei Medical University,Taipei,Taiwan
Scopus学科分类	Oncology;Pulmonary and Respiratory Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181719
专题	卓越中心_老年研究院
通讯作者	Hsu, Shih-Ming; Lu, Long-Sheng
作者单位	1.Department of Oncology,Taipei Veterans General Hospital,Taipei,Taiwan; 2.School of Medicine,National Yang-Ming Chiao-Tung University,Taipei,Taiwan; 3.Department of Biomedical Imaging and Radiological Sciences,National Yang-Ming Chiao-Tung University,Taipei,Taiwan; 4.Department of Chest Medicine,Taipei Veterans General Hospital,Taipei,Taiwan; 5.Taipei Cancer Center and Taipei Medical University Hospital,Taipei Medical University,Taipei,Taiwan; 6.Department of Radiation Oncology,Taipei Municipal Wan-Fang Hospital,Taipei,Taiwan; 7.Department of Radiology,School of Medicine,College of Medicine,Taipei Medical University,Taipei,Taiwan; 8.Department of Radiation Oncology,Taipei Medical University,Taipei,Taiwan; 9.TMU Research Center of Cancer Translational Medicine,Taipei Medical University,Taipei,Taiwan; 10.Graduate Institute of Biomedical Materials and Tissue Engineering,College of Biomedical Engineering,Taipei Medical University,Taipei,Taiwan; 11.International Ph.D. Program for Cell Therapy and Regenerative Medicine,College of Medicine,Taipei Medical University,Taipei,Taiwan; 12.Department of Radiation Oncology,Taipei Medical University Hospital,Taipei,Taiwan; 13.Department of Medical Research,Taipei Medical University,Taipei,Taiwan; 14.Oujiang Laboratory,Wenzhou,China; 15.Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,Wenzhou,China; 16.Graduate Institute of Clinical Medicine,College of Medicine,Taipei Medical University,Taipei,Taiwan; 17.Division of Hematology/Oncology,Department of Medicine,Tri-service General Hospital,National Defense Medical Center,Taipei,Taiwan; 18.Division of Hematology and Oncology,Department of Internal Medicine,Taipei Medical University-Shuang Ho Hospital,New Taipei City,Taiwan; 19.Taipei Cancer Center,Taipei Medical University,Taipei,Taiwan
推荐引用方式 GB/T 7714	Wu, Yuan-Hung,Chao, Heng-sheng,Chiang, Chi-Lu,et al. Personalized cancer avatars for patients with thymic malignancies: A pilot study with circulating tumor cell-derived organoids[J]. Thoracic cancer,2023,14(25):2591-2600.
APA	Wu, Yuan-Hung., Chao, Heng-sheng., Chiang, Chi-Lu., Luo, Yung-Hung., Chiu, Chao-Hua., ... & Lu, Long-Sheng. (2023). Personalized cancer avatars for patients with thymic malignancies: A pilot study with circulating tumor cell-derived organoids. Thoracic cancer, 14(25), 2591-2600.
MLA	Wu, Yuan-Hung,et al."Personalized cancer avatars for patients with thymic malignancies: A pilot study with circulating tumor cell-derived organoids".Thoracic cancer 14.25(2023):2591-2600.