The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer

doi:10.3389/fonc.2023.1036458

科研成果详情

题名	The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer
作者	Zhu, Ce 1; Mao, Chenchen2; Cai, Wentao1; Zheng, Jingwei1; Yang, Hui1; You, Tao1; Chen, Jian1; Yu, Yaojun1; Shen, Xian1,3; Li, Liyi 1
发表日期	2023-06-26
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	metabolic syndrome colorectal cancer overall survival postoperative complications propensity score matching
其他关键词	RISK ; ASSOCIATION ; IMPACT ; MEN
摘要	BackgroundMetabolic syndrome (MetS) is associated with poor prognosis in many cancers. However, the relationship between metabolic syndrome and overall survival (OS) in patients with colorectal cancer (CRC) remains unclear. We aimed to comprehensively analyze whether MetS could affect postoperative complications and long-term survival in patients with CRC. MethodsWe included patients who underwent CRC resection at our center between January 2016 and December 2018. Bias was reduced through propensity score matching analysis. Patients with CRC were divided into the MetS and non-MetS groups based on whether they had MetS. Univariate and multivariate analyses were used to identify risk factors affecting OS. ResultsWe included 268 patients; among them, 120 were included for further analysis after propensity score matching. There were no significant between-group differences in the clinicopathological features after matching. Compared with the non-MetS group, the MetS group had a shorter OS (P = 0.027); however, there was no significant between-group difference in postoperative complications. Multivariate analysis revealed that MetS (hazard ratio [HR] = 1.997, P = 0.042), tumor-node-metastasis stage (HR = 2.422, P = 0.003), and intestinal obstruction (HR = 2.761, P = 0.010) were independent risk factors for OS. ConclusionsMetS affects the long-term survival of patients with CRC without affecting postoperative complications.
资助项目	Natural Science Foundation of Zhejiang Province[LTGD23H160005];Wenzhou Science and Technology Bureau[Y20210920];
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	13
DOI	10.3389/fonc.2023.1036458
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001025279000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37434983
SCOPUSEID	2-s2.0-85164694307
通讯作者地址	[Shen, Xian]Department of Gastrointestinal Surgery,The Second Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Li, Liyi]Department of Gastrointestinal Surgery,The Second Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181635
专题	附属第二医院第一临床医学院（信息与工程学院）、附属第一医院附属第一医院基础医学院（机能实验教学中心）_病原生物学与免疫学系
通讯作者	Shen, Xian; Li, Liyi
作者单位	1.Department of Gastrointestinal Surgery,The Second Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Microbiology and Immunology,School of Basic Medical Sciences,Institute of Molecular Virology and Immunology,Wenzhou Medical University,Zhejiang,China; 3.Department of Gastrointestinal Surgery,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	附属第二医院
通讯作者单位	附属第二医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Zhu, Ce,Mao, Chenchen,Cai, Wentao,et al. The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer[J]. FRONTIERS IN ONCOLOGY,2023,13.
APA	Zhu, Ce., Mao, Chenchen., Cai, Wentao., Zheng, Jingwei., Yang, Hui., ... & Li, Liyi. (2023). The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer. FRONTIERS IN ONCOLOGY, 13.
MLA	Zhu, Ce,et al."The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer".FRONTIERS IN ONCOLOGY 13(2023).