A Dual-Targeted Metal-Organic Framework Based Nanoplatform for the Treatment of Rheumatoid Arthritis by Restoring the Macrophage Niche

doi:10.1021/acsnano.3c03828

科研成果详情

题名	A Dual-Targeted Metal-Organic Framework Based Nanoplatform for the Treatment of Rheumatoid Arthritis by Restoring the Macrophage Niche
作者	Tao, Siyue 1,3; Yu, Hao2; You, Tao 5; Kong, Xiangxi 1,3; Wei, Xiaoan 1,3; Zheng, Zeyu 1,3; Zheng, Lin 1,3; Feng, Zhenhua 1,3; Huang, Bao 1,3; Zhang, Xuyang 1,3; Chen, Feng 5; Chen, Xiao 5; Song, Haixin 1,3; Li, Jie 6; Chen, Binhui 6; Chen, Jian 1,3,4; Yao, Qingqing2; Zhao, Fengdong1,3,4
发表日期	2023-07-10
发表期刊	ACS NANO 影响因子和分区
语种	英语
原始文献类型	Article
关键词	metal-organic framework pH-responsive materials rheumatoid arthritis macrophage niche complementsystem osteoclast
其他关键词	RECEPTOR ; PATHWAY ; PATHOGENESIS ; INFLAMMATION ; ANTAGONIST ; INSIGHTS ; BEHAVIOR ; PROTEIN ; IMMUNE ; INJURY
摘要	Inflammatory infiltration and bone destruction are importantpathologicalfeatures of rheumatoid arthritis (RA), which originate from the disturbedniche of macrophages. Here, we identified a niche-disrupting processin RA: due to overactivation of complement, the barrier function of VSIg4 (+) lining macrophages is disrupted and mediatesinflammatory infiltration within the joint, thereby activating excessiveosteoclastogenesis and bone resorption. However, complement antagonistshave poor biological applications due to superphysiologic dose requirementsand inadequate effects on bone resorption. Therefore, we developeda dual-targeted therapeutic nanoplatform based on the MOF frameworkto achieve bone-targeted delivery of the complement inhibitor CRIg-CD59and pH-responsive sustained release. The surface-mineralized zoledronicacid (ZA) of ZIF8@CRIg-CD59@HA@ZA targets the skeletal acidicmicroenvironment in RA, and the sustained release of CRIg-CD59can recognize and prevent the complement membrane attack complex (MAC)from forming on the surface of healthy cells. Importantly, ZA caninhibit osteoclast-mediated bone resorption, and CRIg-CD59can promote the repair of the VSIg4 (+) liningmacrophage barrier to achieve sequential niche remodeling. This combinationtherapy is expected to treat RA by reversing the core pathologicalprocess, circumventing the pitfalls of traditional therapy.
资助项目	Key R&D and Development Projects in Anhui Province[201904a07020107];National Natural Scientific Foundation of China[82072466,82272520,82272521,LQ20H170002];Zhejiang Provincial Natural Science Foundation of China[Z23H060004];
出版者	AMER CHEMICAL SOC
ISSN	1936-0851
EISSN	1936-086X
卷号	17 期号:14 页码:13917-13937
DOI	10.1021/acsnano.3c03828
页数	21
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001025907800001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
在线发表日期	2023-07
EI入藏号	20233114456410
EI主题词	Macrophages
EI分类号	461.9.1 Immunology ; 531.1 Metallurgy ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	37429012
SCOPUSEID	2-s2.0-85165739369
自科自定义期刊分类	T3(B)类
通讯作者地址	[Chen, Jian]Department of Orthopedic Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,310016,China ; [Yao, Qingqing]National Engineering Research Center of Ophthalmology and Optometry,School of Ophthalmology & Optometry,Eye Hospital,Wenzhou Medical University,270 Xueyuan Xi Road, Zhejiang,Wenzhou,325027,China ; [Zhao, Fengdong]Department of Orthopedic Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,310016,China
Scopus学科分类	Materials Science (all);Engineering (all);Physics and Astronomy (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181552
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
通讯作者	Chen, Jian; Yao, Qingqing; Zhao, Fengdong
作者单位	1.Department of Orthopedic Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,310016,China; 2.National Engineering Research Center of Ophthalmology and Optometry,School of Ophthalmology & Optometry,Eye Hospital,Wenzhou Medical University,270 Xueyuan Xi Road, Zhejiang,Wenzhou,325027,China; 3.Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province,Zhejiang,Hangzhou,310016,China; 4.Department of Orthopedic Surgery,Wenzhou Medical University First Affiliated Hospital,Zhejiang,Wenzhou,325000,China; 5.The First Affiliated Hospital of USTC,Division of Life Science and Medicine,CAS Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,School of Chemistry and Materials Science,University of Science and Technology of China,Anhui,Hefei,230026,China; 6.Department of Orthopaedic Surgery,Ningbo Medical Center Li Huili Hospital,Zhejiang,Ningbo,315100,China
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Tao, Siyue,Yu, Hao,You, Tao,et al. A Dual-Targeted Metal-Organic Framework Based Nanoplatform for the Treatment of Rheumatoid Arthritis by Restoring the Macrophage Niche[J]. ACS NANO,2023,17(14):13917-13937.
APA	Tao, Siyue., Yu, Hao., You, Tao., Kong, Xiangxi., Wei, Xiaoan., ... & Zhao, Fengdong. (2023). A Dual-Targeted Metal-Organic Framework Based Nanoplatform for the Treatment of Rheumatoid Arthritis by Restoring the Macrophage Niche. ACS NANO, 17(14), 13917-13937.
MLA	Tao, Siyue,et al."A Dual-Targeted Metal-Organic Framework Based Nanoplatform for the Treatment of Rheumatoid Arthritis by Restoring the Macrophage Niche".ACS NANO 17.14(2023):13917-13937.