The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma

doi:10.1038/s41467-023-39530-1

科研成果详情

题名	The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
作者	Zhou, Meng1; Bao, Siqi 1; Gong, Tongyang 2; Wang, Qiang 3; Sun, Jie1; Li, Jiaqi 1; Lu, Minyi 2; Sun, Wanyuan 2; Su, Jianzhong1; Chen, Hongyan 2,4; Liu, Zhihua 2
发表日期	2023-06-26
发表期刊	Nature communications 影响因子和分区
语种	英语
原始文献类型	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
其他关键词	CANCER
摘要	Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and identified six key malignancy-specific lncRNAs that were integrated into a Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly in distinguishing ESCC from normal controls in multiple in-house and external multicenter validation cohorts, including early-stage I/II cancer. In addition, five candidate lncRNAs were confirmed to have non-invasive diagnostic potential in our institute plasma cohort, showing superior or comparable diagnostic accuracy to current clinical serological markers. Overall, this study highlights the profound and robust dysregulation of lncRNAs in ESCC and demonstrates the potential of lncRNAs as non-invasive biomarkers for the early detection of ESCC.
资助项目	Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2019PT310027];National Natural Science Foundation of China[82188102];CAMS Innovation Fund for Medical Sciences[2021-I2M-1-018,2021-I2M-1-067];Beijing Natural Science Foundation[7212085];National Key Research and Development Program of China[2021YFA1101200,2021YFC2501000,2022YFC3401003];Fundamental Research Funds for the Central Universities[3332021091];Guangdong Basic and Applied Basic Research Foundation[2019B030302012];
出版者	NATURE PORTFOLIO
ISSN	2041-1723
EISSN	2041-1723
卷号	14 期号:1
DOI	10.1038/s41467-023-39530-1
页数	11
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001017010300015
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37365153
SCOPUSEID	2-s2.0-85163396839
自科自定义期刊分类	T2(B)类
通讯作者地址	[Su, Jianzhong]School of Biomedical Engineering,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China ; [Chen, Hongyan]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China ; [Liu, Zhihua]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China
Scopus学科分类	Chemistry (all);Biochemistry, Genetics and Molecular Biology (all);Physics and Astronomy (all)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181225
专题	仁济学院_眼视光、生物医学工程学部
通讯作者	Su, Jianzhong; Chen, Hongyan; Liu, Zhihua
作者单位	1.School of Biomedical Engineering,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China; 2.State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China; 3.Department of Anesthesiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China; 4.Key Laboratory of Cancer and Microbiome,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China
第一作者单位	仁济学院_眼视光、生物医学工程学部
通讯作者单位	仁济学院_眼视光、生物医学工程学部
第一作者的第一单位	仁济学院_眼视光、生物医学工程学部
推荐引用方式 GB/T 7714	Zhou, Meng,Bao, Siqi,Gong, Tongyang,et al. The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma[J]. Nature communications,2023,14(1).
APA	Zhou, Meng., Bao, Siqi., Gong, Tongyang., Wang, Qiang., Sun, Jie., ... & Liu, Zhihua. (2023). The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma. Nature communications, 14(1).
MLA	Zhou, Meng,et al."The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma".Nature communications 14.1(2023).