The association of gut microbiome with recurrent pregnancy loss: A comprehensive review

doi:10.5582/ddt.2023.01010

科研成果详情

题名	The association of gut microbiome with recurrent pregnancy loss: A comprehensive review
作者	Zhu, Jun 1; Jin, Jiaxi 1; Qi, Qing 2,3,4; Li, Lisha 2,3,4; Zhou, Jing 2,3,4; Cao, Liwen 5; Wang, Ling 2,3,4,6
发表日期	2023-06-25
发表期刊	Drug discoveries & therapeutics 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	gut microbiome immunity inflammation insulin resistance obesity recurrent pregnancy loss
其他关键词	DIET-INDUCED OBESITY ; INSULIN-RESISTANCE ; FATTY-ACIDS ; INFLAMMATION ; BUTYRATE ; CELLS ; MISCARRIAGE ; SENSITIVITY ; BACTERIAL ; DISEASE
摘要	The steady-state gut microbiome not only promotes the metabolism and absorption of nutrients that are difficult to digest by the host itself, but also participates in systemic metabolism. Once the dynamic balance is disturbed, the gut microbiome may lead to a variety of diseases. Recurrent pregnancy loss (RPL) affects 1-2% of women of reproductive age, and its prevalence has increased in recent years. According to the literature review, the gut microbiome is a new potential driver of the pathophysiology of recurrent abortion, and the gut microbiome has emerged as a new candidate for clinical prevention and treatment of RPL. However, few studies have concentrated on the direct correlation between RPL and the gut microbiome, and the mechanisms by which the gut microbiome influences recurrent miscarriage need further investigation. In this review, the effects of the gut microbiome on RPL were discussed and found to be associated with inflammatory response, the disruption of insulin signaling pathway and the formation of insulin resistance, maintenance of immunological tolerance at the maternal-fetal interface due to the interference with the immune imbalance of Treg/Th17 cells, and obesity.
资助项目	Taizhou Science and Technology Foundation [1902ky154]; Scientific and Technological Innovation Action Plan of the Shanghai Natural Science Fund [20ZR1409100]; Chinese Association of Integration of Traditional and Western Medicine special foundation for Obstetrics and Gynecology-PuZheng Pharmaceutical Foundation [FCK-PZ-08]; Shanghai Hospital Association [X2021046]; Special Foundation for Healthcare Research of the Shanghai Municipal Health Commission [202150042]; science and technology programs of Zhoushan, Zhejiang [2021C31055]
出版者	INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
ISSN	1881-7831
EISSN	1881-784X
卷号	17 期号:3
DOI	10.5582/ddt.2023.01010
页数	13
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001021364900001
收录类别	PUBMED ; ESCI
在线发表日期	2023-06
URL	查看原文
Pubmed记录号	37357394
通讯作者地址	[Wang, Ling]Fudan Univ, Lab Reprod Immunol Obstet & Gynecol Hosp, 419 Fangxie Rd, Shanghai 200011, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181217
专题	其他_附属温岭医院（温岭市第一人民医院）
通讯作者	Wang, Ling
作者单位	1.Wenzhou Med Univ, Affiliated Wenling Hosp, Wenzhou, Zhejiang, Peoples R China; 2.Fudan Univ, Lab Reprod Immunol Obstet & Gynecol Hosp, Shanghai, Peoples R China; 3.Fudan Univ, Acad Integrat Med, Shanghai, Peoples R China; 4.Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai, Peoples R China; 5.Zhoushan Women & Children Hosp, Ctr Reprod Med, Hangzhou, Zhejiang, Peoples R China; 6.Fudan Univ, Lab Reprod Immunol Obstet & Gynecol Hosp, 419 Fangxie Rd, Shanghai 200011, Peoples R China
第一作者单位	附属温岭医院（温岭市第一人民医院）
第一作者的第一单位	附属温岭医院（温岭市第一人民医院）
推荐引用方式 GB/T 7714	Zhu, Jun,Jin, Jiaxi,Qi, Qing,et al. The association of gut microbiome with recurrent pregnancy loss: A comprehensive review[J]. Drug discoveries & therapeutics,2023,17(3).
APA	Zhu, Jun., Jin, Jiaxi., Qi, Qing., Li, Lisha., Zhou, Jing., ... & Wang, Ling. (2023). The association of gut microbiome with recurrent pregnancy loss: A comprehensive review. Drug discoveries & therapeutics, 17(3).
MLA	Zhu, Jun,et al."The association of gut microbiome with recurrent pregnancy loss: A comprehensive review".Drug discoveries & therapeutics 17.3(2023).